Publications by authors named "Brandon H Dickson"
SARS-CoV-2 interferes with antigen presentation by downregulating major histocompatibility complex (MHC) II on antigen-presenting cells, but the mechanism mediating this process is unelucidated. Herein, analysis of protein and gene expression in human antigen-presenting cells reveals that MHC II is downregulated by the SARS-CoV-2 main protease, NSP5. This suppression of MHC II expression occurs via decreased expression of the MHC II regulatory protein CIITA.
View Article and Find Full Text PDFEfferocytes express multiple receptors that mediate the recognition and engulfment of apoptotic cells through a process known as efferocytosis. Ligation of these receptors induces the formation of a structured efferocytic synapse that mediates the engulfment of the apoptotic cell by the efferocyte. The lateral diffusion of these receptors allows for clustering-mediated receptor activation and is central for the formation of the efferocytic synapse.
View Article and Find Full Text PDFArticle Synopsis
- Bacterial type VIIb secretion systems (T7SSb) are protein complexes in Firmicutes that secrete toxic proteins, helping bacteria compete and cause disease.
- The study investigates domains of unknown function (DUFs) that are often found alongside LXG effector genes, revealing that these DUFs help target the effectors for export.
- Structural analyses show similarities between these DUFs and established T7SS effectors, highlighting a specific motif crucial for the secretion process of LXG effectors.