Potassium-Alkali-Enriched Diet, Hypertension, and Proteinuria following Uninephrectomy.

Key Points: A K-alkali–enriched diet blunted post-uninephrectomy hypertension and facilitated acid clearance by suppressing Na reabsorption. Uninephrectomy-associated proteinuria could be attributed to elevated single-nephron GFR and downregulation of megalin, which reduced fractional protein endocytosis.

Background: Losing or donating a kidney is associated with risks of developing hypertension and albuminuria.

Incretin and glucagon receptor polypharmacology in chronic kidney disease.

Chronic kidney disease is a debilitating condition associated with significant morbidity and mortality. In recent years, the kidney effects of incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1RAs), have garnered substantial interest in the management of type 2 diabetes and obesity. This review delves into the intricate interactions between the kidney, GLP-1RAs, and glucagon, shedding light on their mechanisms of action and potential kidney benefits.

Electrolyte and transporter responses to angiotensin II induced hypertension in female and male rats and mice.

Aim: Sexual dimorphisms are evident along the nephron: Females (F) exhibit higher ratios of renal distal to proximal Na transporters' abundance, greater lithium clearance (C ) more rapid natriuresis in response to saline infusion and lower plasma [K ] vs. males (M). During angiotensin II infusion hypertension (AngII-HTN) M exhibit distal Na transporter activation, lower proximal and medullary loop transporters, blunted natriuresis in response to saline load, and reduced plasma [K ].