Publications by authors named "Brandon D Regalado"
Article Synopsis
- Nuclear hormone receptors (NRs) are important transcription factors that can be targeted for therapy, and their degradation is crucial for treating cancers linked to retinoic acid and estrogen receptors.
- The study identifies UBR5 as a ubiquitin ligase responsible for degrading various agonist-bound NRs, including RARA and RXRA, and reveals structural insights into UBR5's interaction with these receptors.
- The research shows that different ligands can affect the recruitment of coactivators and UBR5 to chromatin, thereby influencing the transcriptional regulation of NRs.
Tumor-initiating cells contained within the aggressive brain tumor glioma (glioma stem cells, GSCs) promote radioresistance and disease recurrence. However, mechanisms of resistance are not well understood. Herein, we show that the proteome-level regulation occurring upon radiation treatment of several patient-derived GSC lines predicts their resistance status, whereas glioma transcriptional subtypes do not.
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