Exploring the Nonenzymatic Origin of Duclauxin-like Natural Products.

Chemical-biological efforts to increase the diversity of duclauxin ()-like molecules for medicinal chemistry purposes unveiled the reactivity of duclauxin () toward amines and alcohols. To expand the compound class, a semisynthetic strategy conjugating amines to duclauxin () was employed. Insights gained from this approach led to the hypothesis that certain duclauxin-like "natural products" such as talaromycesone B (), bacillisporin G (), xenoclauxin (), bacillisporins F (/), bacillisporins J (/), bacillisporins I (/), and verruculosin A () may be isolation artifacts rather than enzymatic products.