Publications by authors named "Brandi Dorsey"
Most alphaviruses are mosquito-borne and can cause severe disease in humans and domesticated animals. In North America, eastern equine encephalitis virus (EEEV) is an important human pathogen with case fatality rates of 30-90%. Currently, there are no therapeutics or vaccines to treat and/or prevent human infection.
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- The study focuses on creating peptide-based ligands using a method called protein catalyzed capture (PCC) to improve molecular binders for sensing and drug delivery.
- Two specific peptides were enhanced: one targeting vascular endothelial growth factor (VEGF) for imaging in living organisms, showing stability and a suitable half-life, and another targeting the protective antigen (PA) of Bacillus anthracis for use in challenging conditions without losing function.
- The research highlights the effectiveness of the PCC screening process in developing advanced alternatives to traditional antibodies for diagnostics and therapeutics.
Recovery efficiencies for Burkholderia thailandensis from various aerosol sampling media.
Front Cell Infect Microbiol
December 2013
Burkholderia thailandensis is used in the laboratory as a surrogate of the more virulent B. pseudomallei. Since inhalation is believed to be a natural route of infection for B.
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