Publications by authors named "Branden Verosky"
Article Synopsis
- - Prebiotic galactooligosaccharides (GOS) have been shown to lower anxiety-like behaviors in both mice and humans, but the underlying biological processes are not fully understood yet.
- - In a study with C57BL/6 mice, GOS supplementation decreased anxiety behaviors and specific inflammatory gene expressions in the brain, alongside changes in gut bacteria and serum metabolite levels.
- - Notably, the metabolite methyl-indole-3-acetic acid (methyl-IAA), produced from bacterial metabolism, was linked to reduced anxiety; administering methyl-IAA directly also lowered anxiety-like behavior and inflammation in brain cells.
Stress and psychiatric disorders have been independently associated with disruption of the maternal and offspring microbiome and with increased risk of the offspring developing psychiatric disorders, both in clinical studies and in preclinical studies. However, the role of the microbiome in mediating the effect of prenatal stress on offspring behavior is unclear. While preclinical studies have identified several key mechanisms, clinical studies focusing on mechanisms are limited.
View Article and Find Full Text PDFMaternal stress during pregnancy is prevalent and associated with increased risk of neurodevelopmental disorders in the offspring. Maternal and offspring immune dysfunction has been implicated as a potential mechanism by which prenatal stress shapes offspring neurodevelopment; however, the impact of prenatal stress on the developing immune system has yet to be elucidated. Furthermore, there is evidence that the chemokine C-C motif chemokine ligand 2 (CCL2) plays a key role in mediating the behavioral sequelae of prenatal stress.
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