Publications by authors named "Bram R Diamond"
Article Synopsis
- This research explores how functional connectivity (FC) in the brain relates to cognitive decline as people age, focusing specifically on differences between highly functional older adults (SuperAgers) and average older adults.
- It highlights inconsistencies in previous studies regarding the role of FC in typical aging, suggesting that methodical problems and varying definitions of "successful aging" contribute to mixed outcomes.
- The study uses advanced MRI techniques to compare FC among SuperAgers and cognitively average older adults to better understand the neurocognitive networks involved in memory performance and to clarify how FC differs between these groups.
Article Synopsis
- Consciousness has two main parts: being awake (arousal) and being aware of things.
- Scientists are trying to learn more about how the brain keeps us awake and alert, focusing on parts below the brain's surface.
- They found important brain areas that help with wakefulness and connected them to parts that help with awareness, showing how these different brain networks work together.
Consciousness is comprised of arousal (i.e., wakefulness) and awareness.
View Article and Find Full Text PDFDiffusion tractography magnetic resonance imaging (MRI) can infer changes in network connectivity in patients with traumatic brain injury (TBI), but the pathological substrates of disconnected tracts have not been well defined because of a lack of high-resolution imaging with histopathological validation. We developed an MRI protocol to analyze tract terminations at 750-μm isotropic resolution, followed by histopathological evaluation of white matter pathology, and applied these methods to a 60-year-old man who died 26 days after TBI. Analysis of 74 cerebral hemispheric white matter regions revealed a heterogeneous distribution of tract disruptions.
View Article and Find Full Text PDFCortical volumetric analysis is widely used to study the anatomic basis of neurological deficits in patients with traumatic brain injury (TBI). However, patients with TBI-related lesions are often excluded from MRI analyses because cortical lesions may compromise the accuracy of reconstructed surfaces upon which volumetric measurements are based. We developed a FreeSurfer-based lesion correction method and tested its impact on cortical volume measures in 87 patients with chronic moderate-to-severe TBI.
View Article and Find Full Text PDFWe present an ultra-high resolution MRI dataset of an ex vivo human brain specimen. The brain specimen was donated by a 58-year-old woman who had no history of neurological disease and died of non-neurological causes. After fixation in 10% formalin, the specimen was imaged on a 7 Tesla MRI scanner at 100 µm isotropic resolution using a custom-built 31-channel receive array coil.
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