Publications by authors named "Brais Muniz Castro"

Inkjet printing has been extensively explored in recent years to produce personalised medicines due to its low cost and versatility. Pharmaceutical applications have ranged from orodispersible films to complex polydrug implants. However, the multi-factorial nature of the inkjet printing process makes formulation (e.

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Article Synopsis
  • Three-dimensional printing (3DP) is gaining traction in healthcare for creating personalized medicine and devices, but the process of developing formulations can be time-consuming.
  • This study combined in-house and literature data on 3DP techniques to create a balanced dataset of 1,594 formulations, improving the accuracy of machine learning models to 84% for predicting printability and filament characteristics.
  • An updated web application was developed to streamline the formulation process by providing predictions on key characteristics, resulting in faster pharmaceutical 3DP research.
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Three-dimensional printing (3DP) is a transformative technology that is advancing pharmaceutical research by producing personalized drug products. However, advances made via 3DP have been slow due to the lengthy trial-and-error approach in optimization. Artificial intelligence (AI) is a technology that could revolutionize pharmaceutical 3DP through analyzing large datasets.

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Artificial intelligence (AI) has the potential to reshape pharmaceutical formulation development through its ability to analyze and continuously monitor large datasets. Fused deposition modeling (FDM) three-dimensional printing (3DP) has made significant advancements in the field of oral drug delivery with personalized drug-loaded formulations being designed, developed and dispensed for the needs of the patient. The FDM 3DP process begins with the production of drug-loaded filaments by hot melt extrusion (HME), followed by the printing of a drug product using a FDM 3D printer.

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