[Acute surgical abdomen in idiopathic haemochromatosis].

The acute abdomen (AA) is a typical but very rare complication of idiopatic haemochromatosis (IH). The possible mechanisms are not sufficiently clarified. We report a case with IH who died with clinical features of (AA) 20 hours after gastroscopy was performed.

[Treatment of peptic ulcer with sucralfate].

Sucralfate made in Bulgaria (Farmaphim) and its Yugoslavian analogue venter have been tried in gastroduodenal ulcer. The drugs were given per os (1 g, 1 tablet) 4 times a day before meals for 20 days. Sucralfate treatment was assigned to 26 patients with gastric and 26 with duodenal ulcer.

[Treatment of duodenal ulcer with ranitidine].

30 patients with endoscopically proved duodenal peptic ulcer were treated with Bulgarian drug Ranatidin in a dose of 150 mg twice daily in the course of 20 days. The pains were relieved up to the third day in 90% of the patients treated and the dyspeptic complaints disappeared in 1-3 days in 96-100% of the patients. Following the treatment course a statistically significant decrease of the gastric secretion indices was established (V, V1) and of the basic acid production (BAO, MAO, PAO) in comparison with the values before the treatment.

[The carcinoembryonic antigen in chronic pancreatitis].

The fasting carcinoembryonal antigen (CEA) concentrations in the serum and duodenal juice and after venous stimulation of the exocrine pancreas with the hormones CCK and secretin (Boots) were studied. Radioimmunologic test with a kit of the firm "Labimex"--PPR was used. 28 patients with clinically proved chronic pancreatitis and a control group of 27 healthy persons were examined.

[Biotidin treatment of duodenal ulcer].

The results of the treatment with the Bulgarian drug biotidin of 30 patients with endoscopically proved duodenal peptic ulcer are presented. The drug was given in a dose of 150 mg twice daily in the course of 20 days. The pain ceased up to the third day in 93.

[Treatment of peptic ulcer using proglumide (Milid)].

20 patients with peptic gastric ulcer and 30 patients with peptic duodenal ulcer were treated with Milid (Proglumid). The following results were achieved: in 85% of the patients with peptic gastric ulcer and in 93% of the patients with duodenal ulcer the pain was relieved on the 4th day on the average. In 95-96% of the patients treated the dyspeptic complaints disappeared on the 2-3 day.

[The differential diagnosis of chronic pancreatitis and pancreatic cancer].

The following examinations were carried out in patients with chronic pancreatitis and pancreatic cancer: pancreozymin-secretin test, sonography, computed axial tomography, endoscopic retrograde cholangiopancreatography (ERCP) and thin-needle aspiration pancreatic biopsy. In 93.4% of the patients with chronic pancreatitis and in 93.

[Computed tomography in cholestasis].

116 patients with jaundice were examined by computer tomography. In 92.3% of the patients examined the computer tomography gave correct information for the etiology of the jaundice: in 36 patients (31%) obstructive jaundice was established; in 71 patients (61.

[Effect of Pharmachim's cimetidine preparation in 200- and 1000-mg ampules on the gastric secretion of duodenal ulcer patients].

Gastric secretion was studied in 30 patients with duodenal ulcer. The trial was carried out in the following way: the patients were divided into two groups of 10 patients each. To the first group of 10 patients on the first day of the examination pentagastrin test was performed by subcutaneous application of Acignost (GDR) in a dose of 6 micrograms/kg body mass; on the second day the same dose of Acignost was injected with simultaneous i.

[Treatment of duodenal ulcer with the Bulgarian preparation gastralgin].

The effect of the new Bulgarian preparation gastralgin was studied in 20 patients with duodenal ulcer. The preparation was given three times daily in the course of 20 days--I bag, 1/2 to 1 hour before meals and in the evening before going to bed. Gastralgin contains in one bag--alginic acid 0.

[Diagnostic potentials of computed tomography in focal liver diseases].

98 patients with focal liver diseases were examined by computer tomography: 29 patients with primary liver cancer, 44 patients with liver metastases, 16 patients with liver cysts, 4 patients with hemangioma and 5 patients with liver abscess. In 92.9% of the patients examined the computer tomographic examination gave accurate information about the focal liver disease.

[Differential diagnosis of jaundice].

Patients with jaundice and hyperbilirubinemia over 34 mumol/l have been examined by different methods in order to assess the diagnostic value of the methods. 340 patients were examined clinically and by laparoscopy, 168 patients and 92 healthy persons were examined by 10 laboratory indices, 639 patients--by ultrasonography, 95 patients--by scintigraphy, 116 patients--by computer tomography, 83 patients--by endoscopic retrograde cholangio-pancreatography (ERCPG), 17 patients--by percutaneous transhepatic cholangiography (PTC), 70 patients--by directed liver biopsy. In the patients with cholestasis the 5'-nucleotidase, alkaline phosphatase, glutamyl transpeptidase (lipoprotein X is positive in 92% of the patients) and cholesterol are increased most.

[Treatment of stomach ulcer with the Bulgarian preparation Farmaxolon].

Thirty-four patients with gastric ulcer were treated with the new Bulgarian preparation pharmaxolon-Pharmachim, for 20 days under clinical conditions. A favourable effect on the clinical symptoms by the pharmaxolon treatment was established but the differences with the control placebo group were statistically insignificant. A total of 47.

[Case of sarcoidosis with predominant involvement of the liver and lymph nodes].

After brief literature data, a clinical case is reported with generalized sarcoidoses with predominant affection of liver and lymph nodes. A detailed clinical-laboratory characteristics is presented and the diagnosis has been histomorphologically objectivized. The hepatocytes were electron-microscopically studied and disorders in carbohydrate metabolism established with predomination of glyconeopoiesis.

[Effect of carsil and legalon in treating chronic liver diseases].

The clinical effect from the treatment of 48 patients with carsil and 24 patients with legalon is studied. The patients were subdivided into three groups in the base of the clinical, laboratory-chemical and instrumental examination: light hepatic lesions--hepatic steatosis, chronic persisting hepatitis (ChPH), post-hepatitis states, chronic active hepatitis (ChAN) and cirrhosis of the liver (CL). Both preparations were administered 3 three times, 2 tablets daily for 3 months.

[Serum immunoreactive trypsin in chronic pancreatitis patients].

The serum immunoreactive trypsin (determined by RIA-gnost Trypsin of the firm Höchst) was studied in 30 patients with chronic pancreatitis: 16 patients in a stage of exacerbation and 14 patients with clinical remission. Via pancreozymin-secretin test pancreatic exocrine insufficiency was established in all patients: 24 patients with moderate disorders and 6 patients with total secretory deficiency. The results were compared with a control group of 13 healthy subjects.

[Case of a patient with liver cirrhosis and Silvestrini-Corda syndrome].

A case with alcoholic cirrhosis of liver is described that was combined with manifested gynecomastia, atrophia of testes and impotence--Silvestrini--Corda syndrome. Changes in the endocrine state of the patient were established--a tendency to reduced estrogens in plasma (estradiol), increased blood cortisol and reduced excretion of its metabolites in urine. The case is of clinical interest because the severe alcoholic hepatic lesion became the cause of the affection of endocrine state and in this way led to manifested classical syndrome of Silvestrini--Corda.

[Changes in the histamine content and morphology of the gastric mucosa in duodenal ulcer after pentagastrin stimulation].

A parallel study on histamine concentration and morphology of biopsy from gastric mucosa, was carried out with 60 patients with duodenal ulcer, prior to and post stimulation with pentagastrin--6 micrograms/kg. Histamine was spectrofluorimetrically determined. The functional-morphological changes that developed were followed up on 15, 30 and 60 min after the stimulation.