Carob Seed Peels Effect on Cognitive Impairment and Oxidative Stress Status in Methionine-Induced Mice Models of Schizophrenia.

(Carob tree) is a Mediterranean evergreen, well known for its medicinal properties. The different parts of Carob were proven to exert antidiabetic, antibacterial, antifungal, and antiproliferative effects. Hence, the present paper aims to validate the positive correlation between the high antioxidant activity of carob seed peels and the improvement of negative symptoms of schizophrenia.

Design new epoxy nanocomposite coatings based on metal vanadium oxy-phosphate MVOPO for anti-corrosion applications.

Epoxy nanocomposite coatings are an essential way to protect petroleum storage tanks from corrosion. For this purpose, the new nanocomposite epoxy coatings (P-M/epoxy composites) have been successfully designed. The P-M/epoxy composites are based on the metal vanadium oxy-phosphate MVOPO (where M = Mg, Ni, and Zn).

Crystal Growth, Single Crystal Structure, and Biological Activity of Thiazolo-Pyridine Dicarboxylic Acid Derivatives.

Four novel TPDCA derivatives were prepared via a supersaturation method combining TPDCA with water, -methyl-2-pyrrolidone (NMP), Na(POH), and ammonia solution: 2(CHNOS)HO (), (CHNOS)CHNO (), (CHNOS)Na(POH) (), and (CHNOS)(NH)(HO) (). Their crystal structures were determined by single-crystal X-ray diffraction. Compounds () and () crystallize in the monoclinic space groups 2 and 2/, respectively, whereas compounds () and () crystallize in the triclinic space group 1̅.

Single crystal structure, vibrational spectroscopy, gas sorption and antimicrobial properties of a new inorganic acidic diphosphates material (NH)Mg(HPO)•2HO.

We report on the successful synthesis of diammonium magnesium dihydrogendiphosphate (V) dihydrate compound (NH)Mg(HPO)•2HO using a wet chemical route. Single crystal X-ray diffraction analysis and micro Raman spectroscopy are employed to characterize the compound. We demonstrate, using a multidisciplinary approach, that this compound is ideal for carbon dioxide (CO) capture in addition to other anthropogenic gasses.

Phytochemistry, bioactivity: suggestion of Ceratonia siliqua L. as neurodegenerative disease therapy.

Carob tree (Ceratonia siliqua L.) is one of the most widespread medicinal plants in the Mediterranean area. Traditionally, it was cultivated for its ethnopharmacological benefits and, more especially, for the seeds, which served as unit of measurement of jewelers "carat.

Dinuclear Cyclam Complex as a Non-Cytotoxic, Anti-Hyperurecemic Lead: In vitro to In vivo Studies.

Background: Uric acid is the end product of purine metabolism in humans and its increased level in serum leads to hyperuricemia. Among the different regulatory factors to control the level of uric acid in humans, xanthine oxidase (XO) is a well-established pharmacological target, as it is directly involved in uric acid production.

Methods: The aim of the study was to present a systematic approach to analyze the xanthine oxidase inhibition studies from in vitro leading to in vivo.

Di-hydro-cyclam dimaleate [H2(cyclam)(maleate)2].

The asymmetric unit of the title mol-ecular salt [systematic name: 1,4,8,11-tetraazacyclotetradecane-1,8-diium bis(3-carboxy-prop-2-enoate)], C10H26N4 (2+)·2C4H3O4 (-), contains two half-cations (both completed by crystallographic inversion symmetry) and two maleate anions. The cyclam macrocycles adopt trans-III conformations, supported by two intra-molecular N-H⋯O hydrogen bonds. The O-bonded H atom of each maleate ion is disordered over two positions with an occupancy ratio of 0.

Ortho-rhom-bic polymorph of (6,7-dimeth-oxy-1,2,3,4-tetra-hydro-isoquinolin-1-yl)methanol.

The asymmetric unit of the title compound, C(12)H(17)NO(3), contains two mol-ecules with different conformations. It is a polymorph of the monoclinic form [El Antri et al. (2004 ▶).

1,4,8,11-Tetra-azoniacyclo-tetradecane diaqua-tetra-chloridomanganese(II) dichloride dihydrate.

The title compound, (C(10)H(28)N(4))[MnCl(4)(H(2)O)(2)]Cl(2)·2H(2)O, consists of isolated octa-hedral [MnCl(4)(H(2)O)(2)](2-) anions, tetra-protonated 1,4,8,11-tetra-azoniacyclo-tetradecane cations, chloride anions and water mol-ecules connected by a network of hydrogen bonds. The Mn(II) atom is situated on an inversion centre, and the 1,4,8,11-tetra-azoniacyclo-tetradecane cation is located on a mirror plane.

Reinvestigation of 4-methyl-anilinium dihydrogen phosphite.

The crystal structure of the title compound, C(7)H(10)N(+)·H(2)PO(3) (-), has been reported previously by Sabounchei & Naghipour [Asian J. Chem. (2003) ▶, 15, 1677-1686].

Dilead(II) hydrogen-phosphite dinitrate.

In the title compound, Pb(2)(HPO(3))(NO(3))(2), the two distinct Pb(2+) ions (both with site symmetry m) adopt irregular PbO(10) coordination polyhedra. The structure is completed by two distinct nitrate groups (in which one O atom and the N atom have m site symmetry for both ions) and an HPO(3) (2-) anion (in which one O atom and the P and H atoms have m site symmetry). The connectivity of the PbO(10), NO(3) and HPO(3) units in the crystal structure results in a three-dimensional network.

Ni(2)Si(P(2)O(7))(2).

Dinickel(II) silicon bis-[diphosphate(4-)], Ni(2)Si(P(2)O(7))(2), is isotypic with other phosphates of the formula M(2)Si(P(2)O(7))(2) (M = Co, Cd). All atoms except Si (site symmetry 2) are found in general positions. Ni(2)O(10) dimers formed from edge-sharing NiO(6) octa-hedra are linked by corners and O-P-O bridges, forming slabs parallel to (100), which are in turn inter-connected by O-Si-O contacts.

Poly[ethane-1,2-diammonium tetra-μ-chlorido-cadmate(II)].

The framework of the title compound, {(NH(3)CH(2)CH(2)NH(3))[CdCl(4)]}(n), is built upon layers parallel to (100) made up from corner-sharing [CdCl(6)] octa-hedra. NH(3)CH(2)CH(2)NH(3) (2+) cations are situated between the layers and are linked to the layers via an N-H⋯Cl hydrogen-bonding network. The Cd atom is located on an inversion centre and the coordination environment is described as highly distorted octa-hedral.

Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Small molecules have been shown to be potent and selective probes to understand cell physiology. Here, we show that imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines compose a class of compounds that target essential, conserved cellular processes. Using validated chemogenomic assays in Saccharomyces cerevisiae, we discovered that two closely related compounds, an imidazo[1,2-a]pyridine and -pyrimidine that differ by a single atom, have distinctly different mechanisms of action in vivo.

Dicaesium magnesium bis-(dihydrogen phosphate(V)) dihydrate.

The title compound, Cs(2)Mg(H(2)P(2)O(7))(2)·2H(2)O, is isostructural with the related known isoformular phosphates. The crystal framework consists of corner-sharing MgO(6) and H(2)P(2)O(7) polyhedra, leading to tunnels parallel to the b-axis direction in which Cs(+) ions are located. The H(2)P(2)O(7) unit shows a bent eclipsed conformation.

Ammonium ytterbium(III) diphosphate(V).

The title compound, NH(4)YbP(2)O(7), crystallizes in the KAlP(2)O(7) structure type and consists of distorted YbO(6) octa-hedra and bent P(2)O(7) (4-) diphosphate units forming together a three-dimensional network. There are channels in the structure running along the c axis, where the NH(4) (+) cations are located. They are connected via N-H⋯O hydrogen bonds to the terminal O atoms of the diphosphate anions.

2-Phenyl-imidazo[1,2-a]pyridine-3-carbaldehyde.

In the title compound, C(14)H(10)N(2)O, the dihedral angle between the imidazo[1,2-a]pyridine and phenyl rings is 28.61 (4)° The mol-ecules are connected into broad chains parallel to the a axis by weak C-H⋯O and C-H⋯N hydrogen bonds. The linking of the ribbons is provided by π-π stacking inter-actions between neighbouring pyridine rings, with a centroid-centroid distance of 3.

N-(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)acetamide.

The crystal structure of the title compound, C(15)H(13)N(3)O, consists of columns of mol-ecules that are inter-connected by N-H⋯N hydrogen bonds in the direction of the b axis. The torsion angle between the imidazo[1,2-a]pyridine ring system and the phenyl ring is 9.04 (5)°.

Terbium(III) hydrogendiphosphate(V) tetra-hydrate.

The Tb atom of the title compound, TbHP(2)O(7)·4H(2)O, is coordinated by the O atoms of three symmetrically independent water mol-ecules and by five O atoms belonging to HP(2)O(7) (-) groups. The TbO(8) polyhedra are inter-connected by the diphospate anions, forming a three-dimensional network which is additionally stabilized by O-H⋯O hydrogen bonding between water mol-ecules and O atoms of the HP(2)O(7) (-) anions. Uncoordinated water mol-ecules are situated in channels and are connected via hydrogen bonds with the framework.

Isolation and X-ray crystal structure of tetrahydroisoquinoline alkaloids from Calycotome villosa Subsp. intermedias.

Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia. Their structures were established as (R)-1-hydroxymethyl-7-8-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (1) and (S)-7-hydroxymethyl-2-3-dimethoxy-7,8,9,10-tetrahydroisoquinoline chloride (2) by spectroscopic techniques and X-ray diffraction analysis.

Flavone glycosides from Calycotome villosa Subsp. Intermedia.

The known flavonoid chrysin-7-O-(beta-D-glycopyranoside) (chrysin glucoside,1) as a major fraction and a new glycoside flavone, chrysin-7-O-beta-D-[(6"-acetyl)glycopyranoside] (2) were isolated from the flowers and leaves of Calycotome Villosa Subsp. Intermedia, They were identified by UV-Vis, 1R, (1)H-, (13)C-NMR and ESI-MS.

The incommensurately and commensurately modulated crystal structures of chromium(II) diphosphate.

Chromium(II) diphosphate, Cr(2)P(2)O(7), has an incommensurately modulated structure at ambient conditions with a = 7.05, b = 8.41, c = 4.

K2M(H2P2O7)2.2H2O (M = Ni, Cu, Zn): orthorhombic forms and Raman spectra.

The crystal structures of three isotypic orthorhombic dihydrogendiphosphates, namely dipotassium copper(II)/nickel(II)/zinc(II) bis(dihydrogendiphosphate) dihydrate, K2M(H2P2O7)2.2H2O (M = Cu, Ni and Zn), have been refined from single-crystal data. The M2+ and K+ cations are located at sites of m symmetry, and the P atoms occupy general positions.

Isolation and X-ray crystal structure of a new isoquinoline-N-oxide alkaloid from Calycotome villosa subsp. intermedia.

A new isoquinoline-N-oxide alkaloid was extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome villosa subsp. intermedia. Its structure was established as 1-hydroxymethyl-6,7-dimethoxyisoquinoline-N-oxide (1) by spectroscopic techniques and X-ray diffraction analysis.