Publications by authors named "Brahim El Hejjioui"
Article Synopsis
- Autosomal dominant intellectual development disorder-6 (MRD6) is caused by a gene mutation leading to various neurodevelopmental issues, including cognitive disabilities and autism-like traits.
- A case study of a three-year-old Moroccan boy highlights the complexity of MRD6, as initial tests were inconclusive until exome sequencing revealed a pathogenic nonsense mutation in a gene associated with the disorder.
- The findings emphasize the importance of the identified gene in brain development and underline the significance of new genetic mutations in understanding intellectual developmental disorders.
Diagnostics (Basel)
June 2023
Article Synopsis
- Triple-negative breast cancer (TNBC) is a subtype of breast cancer that doesn't express hormone receptors or HER2, and is known for its aggressive nature and high rates of metastasis and relapse.
- The review discusses the various molecular subtypes and biomarkers associated with TNBC, focusing on elements that regulate cell behavior, DNA damage, and immune responses.
- Additionally, it highlights advanced research methods like genomics and transcriptomics for understanding TNBC further, and mentions new treatment options including immunotherapy and targeted therapies.
Diagnostics (Basel)
January 2023
Article Synopsis
- Breast cancer is diverse and classified into subtypes based on its molecular characteristics, with triple-negative breast cancer being particularly aggressive and difficult to treat.
- Around 6-10% of new breast cancer cases are metastatic from the start, and 20-30% of existing cases experience metastatic recurrences, highlighting the need for better predictive genetic markers.
- Liquid biopsy techniques can analyze circulating tumor DNA for a detailed understanding of breast cancer, offering potential for improved diagnosis and treatment strategies.
