Publications by authors named "Brady N Zell"
Article Synopsis
- Oncolytic viruses (OVs) can kill cancer cells directly and stimulate the immune system; researchers tested conditionally-replicating adenoviruses (CRAds) armed with immune-stimulating genes in a mouse melanoma model.
- Both single CRAd treatments improved tumor control and increased survival compared to a control, but the combination of CRAd657-m4-1BBL and CRAd657-mCD40L yielded the best results in slowing tumor growth and enhancing the immune response.
- The study found that the combination of these OVs boosted CD8 and CD4 T cell infiltration into tumors, improved anti-tumor immune responses, and led to visible changes in adjacent tissue, suggesting a synergistic effect in cancer treatment.
