Publications by authors named "Brady M O'Boyle"
Article Synopsis
- Over the last 20 years, two dangerous viruses (SARS-CoV-1 and SARS-CoV-2) were discovered to jump from animals to humans, causing serious illness and highlighting the need for new medicines to fight them.
- Scientists studied a specific part of a bat coronavirus (PLpro) to understand how these viruses work and what makes them different, which could help in creating better treatments.
- They developed 30 new drug-like compounds that could block the action of PLpro in these viruses and ran tests to see how effective and safe these new medicines might be.
Post-translational modification of host and viral proteins by ubiquitin and ubiquitin-like proteins plays a key role in a host's ability to mount an effective immune response. Avian species lack a ubiquitin-like protein found in mammals and other non-avian reptiles; interferon stimulated gene product 15 (ISG15). ISG15 serves as a messenger molecule and can be conjugated to both host and viral proteins leading them to be stabilized, degraded, or sequestered.
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