Memory T-Cells Contribute to Calcium Release from Bones during Lactation in Mice.

Milk production during lactation places a high demand for calcium that is fulfilled both from maternal bone resorption and diet. While it is known that mammary gland-derived PTHrP drives bone resorption during lactation, the impact of postpartum estrogen loss on bone has been unclear. We used a case-control study design to test the effect of estrogen loss in lactating mice.