Publications by authors named "Bradley R Melvin"
Article Synopsis
- Alpha-synuclein seed amplification assays (αSyn-SAAs) are emerging diagnostic tools for Parkinson's disease that detect misfolded proteins and amplify their signals through an in vitro process.*
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- Recent studies demonstrate that various biospecimens, such as cerebrospinal fluid (CSF), skin, and submandibular glands, can effectively differentiate between Parkinson's patients and healthy individuals using these assays.*
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- To improve assay reliability and reduce variability, a new high-yield purification protocol for αSyn protein was developed, resulting in significant yields and enhanced performance in distinguishing between disease and control tissues.*
