Enlarged perivascular spaces are associated with white matter injury, cognition and inflammation in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Enlarged perivascular spaces have been previously reported in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, but their significance and pathophysiology remains unclear. We investigated associations of white matter enlarged perivascular spaces with classical imaging measures, cognitive measures and plasma proteins to better understand what enlarged perivascular spaces represent in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and whether radiographic measures of enlarged perivascular spaces would be of value in future therapeutic discovery studies for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Twenty-four individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and 24 age- and sex-matched controls were included.

Hexapod.

SAGE III (Stratospheric Aerosol and Gas Experiment), an Earth-observation instrument developed by NASA's Langley Research Center (LaRC), was one of the first scientific external payloads selected for the International Space Station. It was conceived to fly on a spacecraft able to provide +/- 1 degree pointing accuracy. Since the ISS's attitude can vary by several degrees over a long period, it was therefore necessary to provide a dedicated nadir-pointing system.