Publications by authors named "Bradley Kwinta"
Article Synopsis
- There are currently no established maintenance protocols for cutaneous lymphomas, prompting a study to analyze treatments and outcomes during the COVID-19 pandemic.
- The research included data from 149 patients across nine international institutions, revealing younger patients tended to have earlier stages of the disease and more commonly received skin-directed therapies.
- Findings indicated that treatment interruptions were linked to disease progression and poorer outcomes, with patients experiencing interruptions twice as likely to progress compared to those who maintained their treatments, highlighting the importance of continuous maintenance therapies.
Article Synopsis
- Researchers investigated cases of lymphoproliferative disorders (LPDs) and cutaneous lymphomas that appeared after COVID-19 vaccination, examining the link between specific vaccines and these reactions.
- They found 50 biopsy-proven cases primarily from the U.S., Italy, and Greece, with the Pfizer-BioNTech vaccine associated with 72% of these instances.
- Most patients experienced favorable outcomes, with a common form being lymphomatoid papulosis, and treatment options varied from observational care to medication like steroids and methotrexate.
Individual reports described lymphoproliferative disorders (LPDs) after COVID-19 vaccination; however, the relationship between cases is unexamined. We aim to determine if there are cases of cutaneous LPDs associated with COVID-19 vaccination and their outcomes. We present a review of world literature, vaccine registries, and two unreported cases of LPDs after COVID-19 vaccination.
View Article and Find Full Text PDFBackground: Patients facing a cutaneous lymphoma diagnosis frequently turn to the internet for information but finding patient-accessible education may be a challenge.
Objective: To investigate accessibility and readability of patient-oriented online education on cutaneous lymphomas, including cutaneous T-cell and B-cell lymphoma subtypes.
Methods: This study queried a search engine for 11 cutaneous lymphoma terms, resulting in 1083 webpages.
Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally aggressive cutaneous malignancy. Complete resection is the primary treatment but there is debate over the optimal method. Wide local excision was traditionally the standard of care; however, National Comprehensive Cancer Network guidelines now recommend Mohs micrographic surgery as the preferred approach.
View Article and Find Full Text PDFIntroduction: Psoriasis is a common inflammatory skin disease that significantly impacts patients' psychosocial wellbeing. Despite increasingly effective treatment options, the recurrence of plaques after discontinuation of therapy in many patients highlights the need for additional therapies.
Methods: We report two cases of patients with concurrent psoriasis and mycosis fungoides who were treated with topical mechlorethamine (MCH).
(1) Melanoma is the most aggressive dermatologic malignancy, with an estimated 106,110 new cases to be diagnosed in 2021. The annual incidence rates continue to climb, which underscores the critical importance of improving the methods to prevent this disease. The interventions to assist with melanoma prevention vary and typically include measures such as UV avoidance and the use of protective clothing, sunscreen, and other chemopreventive agents.
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