Publications by authors named "Bradley Hurst"
This study aimed to determine whether the use of vaginal Endometrin plus intramuscular progesterone on every third day (VIM) in programmed frozen embryo transfer (FET) is associated with lower pregnancy and live birth rates compared to daily intramuscular progesterone (IM). FET data from a single program were collected between November 2018 and December 2021. A total of 903 FETs were analyzed, including 504 FETs in the IM group, and 399 FETs in the VIM group.
View Article and Find Full Text PDFArticle Synopsis
- The practice of in vitro fertilization (IVF) has evolved significantly since its inception in 1978, particularly in response to the high rates of twin and multiple births associated with early IVF methods.
- From over 30% of IVF cycles resulting in twin or higher-order pregnancies in the mid-1990s, the rate decreased to less than 7% by 2019 due to advancements in technology and changes in medical guidelines.
- These improvements included better embryo culturing and freezing techniques, genetic testing, and the standardization of single-embryo transfers, leading to an impressive 80% reduction in multifetal pregnancies while maintaining treatment success rates.
Objective: To identify changes in current practice patterns, salaries, and satisfaction by gender and by years in practice among board-certified reproductive endocrinology and infertility (REI) subspecialists in the United States.
Design: Cross-sectional web-based survey including 37 questions conducted by the Society for Reproductive Endocrinology and Infertility.
Setting: Not applicable.
Background: Hysteroscopy requires accurate collection of unabsorbed distension media to measure patient fluid absorption. We assessed the effectiveness and usability of a novel total capture drape compared with a standard drape during hysteroscopy.
Method: Simulation trials were followed by an early-phase study to compare fluid-capture efficiency and measures of drape usability during hysteroscopy randomizing the total capture drape compared with a standard drape.
Objective: To determine research interests of reproductive endocrinology and infertility (REI) physicians and assess their academic productivity.
Design: A questionnaire composed by the Society for REI (SREI) board members was e-mailed to members. PubMed was queried to quantify peer-reviewed publications.
Objective: To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls.
Setting: Hospital emergency department.
Participants: 21 women ages 18-35 with TBI and 21 controls.
Purpose: Fatty acids have been shown to play an important role in oocyte competence and early implantation of the embryo. Our hypothesis-generating study sought to determine if individual fatty acids expressed as a percentage of total erythrocyte fatty acids are associated with embryo quality and other in vitro fertilization (IVF) outcomes.
Methods: This was a prospective cohort study at an academic fertility center.
Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design.
View Article and Find Full Text PDFObjective: To determine whether the period of ejaculatory abstinence (EA) influences the total antioxidant capacity (TAC) of semen or lipid peroxidation (LPO) of sperm membranes.
Design: A prospective experimental trial.
Setting: Academic medical center for reproductive endocrinology and infertility.
Objective: To determine how often women with Ehlers-Danlos syndrome experience obstetric and gynecologic issues both compared with the general population and within the three most common subtypes of Ehlers-Danlos syndrome.
Methods: An anonymous, prospective, online questionnaire in English was posted to the Ehlers-Danlos National Foundation web site (http://ednf.org).
Purpose: To determine if endometrial gene expression is different in women with endometriosis-related infertility and fertile women.
Methods: Prospective study of mid-follicular phase endometrium in 47 subjects in two phases: microarray study of 10 infertile women with endometriosis and five fertile controls, and a quantitative real-time PCR (qRT-PCR) study of 27 infertile women with endometriosis and 15 fertile controls. Gene expression was determined by DNA microarray, and qRT-PCR used for 12 "promising" genes based on the microarray analysis.
Objective: To assess whether blood type was associated with diminished ovarian reserve (DOR) (day-3 follicle-stimulating hormone level >10 IU/L), controlling for history of tobacco smoking, body mass index (BMI), history of endometriosis, ovarian surgery, previous pregnancy, and maternal age.
Design: Cross-sectional study.
Setting: Academic medical center, Division of Reproductive Endocrinology and Infertility.
Objective: To study the effect of ketorolac, a potent anti-inflammatory medication, on in vitro fertilization (IVF) pregnancy outcomes when used at the time of oocyte retrieval.
Design: Retrospective review of 454 patients from 2003-2009.
Setting: Tertiary hospital-affiliated fertility center.
Study Question: Can uterine scar healing after laparoscopic intracapsular myomectomy (LIM) be adequately monitored by traditional two-dimensional (2D) ultrasound (US) and Doppler velocimetry?
Summary Answer: The myometrial area of the scar after LIM can be followed by 2D US and Doppler velocimetry.
What Is Known Already: Apart from post-surgical adhesions, the main concern linked to laparoscopic myomectomy is the quality of healing of the myometrial incision: it has been suggested that US could be useful for assessing uterine scars after myomectomy. However, no diagnostic method has yet been widely accepted to assess the healing process.
Given the increases in 5-year cancer survival and recent advances in fertility preserving technologies, an increasing number of women with cancer are presenting for discussion of fertility preserving options. This review will summarize the risk of infertility secondary to cancer treatment, available treatment options for fertility preservation, and techniques to reduce future risks for patients. Concerns that will be addressed include the risk of the medications and procedures, the potential delay in cancer treatment, likelihood of pregnancy complications, as well as the impact of future pregnancy on the recurrence risk of cancer.
View Article and Find Full Text PDFObjective: To describe a comprehensive approach to women with severe Asherman syndrome and amenorrhea, including preoperative, operative, and postoperative care and subsequent resumption menses, and pregnancy.
Design: Retrospective case series.
Setting: Tertiary care teaching hospital.
An ejaculatory abstinence period of
Objective: The objective of the study was to determine the efficacy of a novel "stair-step" clomiphene protocol in women with polycystic ovarian syndrome (PCOS) who do not respond to 50 mg clomiphene.
Study Design: This was a retrospective analysis at an academic fertility center. The stair-step protocol is performed as follows: 50 mg clomiphene for 5 days, ultrasonography on days 11-14.