Publications by authors named "Bradley D Murphy"
Background: Very few studies have investigated risk factors for cytomegalovirus (CMV) retinitis. Identifying these risk factors will have many benefits, including helping establish screening regimens, examination frequency regimens, and targeted prophylaxis with oral therapy with valganciclovir or other anti-CMV agents. The purpose of this study was to determine the laboratory-based risk factors for CMV retinitis in patients with AIDS.
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- The study aimed to identify clinical risk factors for cytomegalovirus (CMV) retinitis in AIDS patients by comparing 120 diagnosed cases with 159 controls.
- Key significant predictors included visual symptoms like flashing lights (OR 11.42), the presence of cotton-wool spots (OR 2.90), and a history of opportunistic infections, particularly previous nonocular CMV infection (OR 82.99).
- The findings can help clinicians and health policy experts create effective screening and examination protocols to manage the risk of CMV retinitis in affected patients.