Publications by Bradford L Cottrell

Publications by authors named "Bradford L Cottrell"

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Neuroregeneration in composite tissue allografts: effect of low-dose FK506 and mycophenolate mofetil immunotherapy.

Bradford L Cottrell Gustavo Perez-Abadia Stephen M Onifer David S Magnuson Darlene A Burke

Plast Reconstr Surg

September 2006

Background: The immunosuppressant FK506 has been reported to increase the rate of peripheral nerve regeneration in nerve crush injury and nerve allograft models. The purpose of this study was to determine whether low doses of FK506 and mycophenolate mofetil had a neuroregenerative effect in revascularized peripheral nerve allografts in a rat hind limb transplantation model.

Methods: Wistar Furth rat recipients received limbs from syngeneic Wistar Furth donors (group 1, n = 4) or from allogeneic August X Copenhagen Irish rat donors (group 2, n = 6).

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- Bradford L Cottrell's research primarily focuses on neuroregeneration and immunotherapy in the context of composite tissue allografts, particularly examining the effects of specific immunosuppressants on nerve regeneration.
- In his 2006 study, Cottrell investigated the impact of low-dose FK506 and mycophenolate mofetil on peripheral nerve allografts in a hind limb transplantation model in rats, highlighting significant findings related to nerve regeneration rates.
- The research suggests that the combination of FK506 and mycophenolate mofetil may enhance neuroregenerative outcomes in transplanted tissues, paving the way for improved immunotherapeutic strategies in clinical transplantation practices.

Publications by authors named "Bradford L Cottrell"

Neuroregeneration in composite tissue allografts: effect of low-dose FK506 and mycophenolate mofetil immunotherapy.

Synopsis of recent research by authors named "Bradford L Cottrell"