Publications by authors named "Bradford C Feldman"
J Neurotrauma
September 2020
Article Synopsis
- Traumatic brain injury (TBI) is a significant cause of death and disability among individuals under 45, often leading to complex interactions between inflammation and metabolism involving fatty acids like omega-3.
- In a study involving 130 trauma patients, higher plasma levels of docosahexaenoic acid (DHA) were found in TBI patients compared to non-TBI patients 24 hours post-injury, demonstrating a potential link between PUFA levels and TBI severity.
- The genetic variant rs174537 was found to be associated with PUFA metabolism and inflammatory responses, indicating that certain genotypes (like GG) could correlate with higher DHA and inflammatory cytokine levels, leading to worse outcomes after T
