Publications by authors named "Braden J Larson"
Article Synopsis
- * While most animal species possess certain essential genes related to the MuvB complex, bilaterian nematodes lost these genes long ago, yet some conserved protein interactions remain, suggesting evolutionary links.
- * Experiments show that the Myb protein from distant relatives can still interact with nematodes' LIN9 and LIN52 proteins, potentially activating gene expression similarly to what happens in other animals, hinting at an alternative regulatory pathway in nematodes.
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- Meiotic recombination is crucial for the segregation of homologous chromosomes, but male Caenorhabditis species face challenges due to their hemizygous X chromosome that lacks a homologous partner.*
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- A study of several Caenorhabditis species with different reproductive strategies revealed that gonochoristic males induce more meiotic double-strand breaks (DSBs) than androdioecious males, despite similar recombination structures.*
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- Notably, androdioecious species like C. elegans and C. briggsae show flexibility in DSB repair and transient pairing of the X chromosome, while gonochoristic species such as C. remanei and C.
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- - In certain species, during meiosis, the heterogametic sex experiences a process called meiotic sex chromosome inactivation (MSCI), which leads to the silencing of sex chromosomes; this study focused on four Caenorhabditis species to investigate their chromatin landscape during meiosis.
- - Although MSCI is present in all four species studied, the specific chromatin modifications associated with repression differ and do not correlate with whether the species are gonochoristic or hermaphroditic; for example, C. elegans and C. remanei have different methylation patterns compared to C. briggsae and C. brenneri.
- - The research findings indicate that certain histone
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Article Synopsis
- Meiosis relies on chromosome pairing and crossover recombination, with double-strand breaks (DSBs) being crucial for this process, particularly in the X chromosome of Caenorhabditis elegans males, which are hemizygous (having only one copy).
- The study shows that DSB formation and chromosome interactions in male germ cells are closely linked, and a temporary structure called pseudosynapsis allows sister chromatids on the X chromosome to behave similarly to homologous chromosomes during repair.
- Interestingly, X chromosome repair seems to bypass traditional homologous recombination pathways and can engage other methods like single-strand annealing, indicating a unique adaptation for the repair mechanisms in hemizygous sex chromosomes.
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