A dynamic in vitro developing testis model reflects structures and functions of testicular development in vivo.

To better define appropriate applications of our 3-dimensional testicular co-culture as a model for reproductive toxicology, we evaluated the ability of the model to capture structural and functional elements that can be targeted by reproductive toxicants. Testicular co-cultures were prepared from postnatal day 5 male rats and cultured with a Matrigel overlay. Following a 2-day acclimation period, we characterized functional pathway dynamics by evaluating morphology, protein expression, testosterone concentrations, and global gene expression at a range of timepoints from experimental days 0-21.

An exomoon survey of 70 cool giant exoplanets and the new candidate Kepler-1708 b-i.

Exomoons represent a crucial missing puzzle piece in our efforts to understand extrasolar planetary systems. To address this deficiency, we here describe an exomoon survey of 70 cool, giant transiting exoplanet candidates found by Kepler. We identify only one exhibiting a moon-like signal that passes a battery of vetting tests: Kepler-1708 b.

Feasibility of rapid polymerase chain reaction for detection of methicillin-resistant Staphylococcus aureus colonization among emergency department patients with abscesses.

Purpose: In the era of community-associated methicillin-resistant Staphylococcus aureus (MRSA), clinicians face a difficult challenge when selecting antibiotics to treat abscesses. The lack of rapid diagnostics capable of identifying the causative organism often results in suboptimal antibiotic stewardship practices. Although not fully elucidated, the association between MRSA colonization and subsequent infection represents an opportunity to enhance antibiotic selectivity.

The phase-dependent infrared brightness of the extrasolar planet upsilon Andromedae b.

The star upsilon Andromedae is orbited by three known planets, the innermost of which has an orbital period of 4.617 days and a mass at least 0.69 that of Jupiter.

Probing the faintest stars in a globular star cluster.

NGC 6397 is the second closest globular star cluster to the Sun. Using 5 days of time on the Hubble Space Telescope, we have constructed an ultradeep color-magnitude diagram for this cluster. We see a clear truncation in each of its two major stellar sequences.

A young white dwarf companion to pulsar B1620-26: evidence for early planet formation.

The pulsar B1620-26 has two companions, one of stellar mass and one of planetary mass. We detected the stellar companion with the use of Hubble Space Telescope observations. The color and magnitude of the stellar companion indicate that it is an undermassive white dwarf (0.