Publications by authors named "Bozkurt D"

Article Synopsis
  • Hemophagocytic syndrome (HPS) is a serious condition that can lead to heart failure, and this study aimed to find out which factors are predictors of developing heart failure in these patients.* -
  • Using CART analysis on 146 HPS patients, researchers discovered that factors like cardiothoracic ratio (CTR), NT-proBNP levels, and C-reactive protein (CRP) are significant predictors, with CTR being the most critical one.* -
  • The results underscore the importance of early identification of these predictors to improve patient outcomes and inform future research on managing heart failure in HPS.*
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Atmospheric rivers (ARs) reaching high-latitudes in summer contribute to the majority of climatological poleward water vapor transport into the Arctic. This transport has exhibited long term changes over the past decades, which cannot be entirely explained by anthropogenic forcing according to ensemble model responses. Here, through observational analyses and model experiments in which winds are adjusted to match observations, we demonstrate that low-frequency, large-scale circulation changes in the Arctic play a decisive role in regulating AR activity and thus inducing the recent upsurge of this activity in the region.

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The Antarctic Peninsula (AP) has displayed a propensity for persistent blocking ridges and anticyclonic conditions, particularly during recent summertime extreme weather events. This study investigates atmospheric blocking patterns over the AP through historical (1981-2010) and future (2071-2100, SSP5-8.5) periods using ERA5 reanalysis and six CMIP6 models, including multi-member realizations from two models totaling ten simulations.

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Background: Intensive care unit (ICU) survival of cancer patients has improved. Urgent chemotherapy has become feasible in critically ill patients with specific organ dysfunction due to hematological malignancies.

Objective: The aim of the study was to assess ICU mortality rates and the factors associated with mortality in patients with hematologic malignancies receiving urgent chemotherapy in the ICU.

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Purpose: To investigate sarcopenia and related factors and to determine the disease-specific phase angle (PhA) cut-off score in detecting sarcopenia in elderly patients with Parkinson's Disease (PD).

Methods: This cross-sectional study was conducted with 89 participants. The Mini-Nutritional Assessment (MNA), the Eating Attitude Test-10 (EAT-10), the Physical Activity Scale for The Elderly (PASE) questionnaire and the Hoehn-Yahr scale have been used.

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Article Synopsis
  • Sepsis is a serious condition caused by an abnormal immune response to infection, and the study focuses on how genetic differences in the vitamin D receptor (VDR) gene, specifically the FokI polymorphism, may influence outcomes in sepsis patients.
  • The study analyzed 192 patients (96 with sepsis and 96 without) in the ICU and found that in-hospital mortality was significantly higher in the sepsis group (27.1%) compared to the non-sepsis group (8.33%).
  • Results indicated that while there was no significant difference in VDR genotype frequencies between survivors and non-survivors in the sepsis group, those with the homozygous C allele had lower mortality rates, suggesting a potential
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Article Synopsis
  • The study evaluated how the timing of antimicrobial therapy impacts the clinical progress of septic shock patients, involving 204 adults diagnosed using Sepsis-3 criteria.
  • Only 26.4% of patients received antibiotic treatment within the first hour after vasopressors, and there was no significant difference in one-month mortality between those with or without appropriate initial antibiotic coverage.
  • Key factors influencing one-month survival included timely antibiotic initiation, patient location, and specific clinical scores, leading to a recommendation for improved training and electronic alerts for septic shock recognition and treatment in hospitals.
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Using data from SCAR observations, ERA5 reanalysis, and regional climate model simulations (RACMO), we examined the influence of large- and regional-scale climate forcing on temperature and precipitation variations in the South Shetland Islands (SSI). Specifically, we focused on understanding how regional climate indices influence the temporal variability of temperature and precipitation on the SSI. Our findings indicate that both large- and regional-scale climate indices significantly impact the interannual and seasonal temperature variability in the SSI.

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Background: The Women's Wellness with Type 2 Diabetes Programme (WWDP) is an online behavioural intervention for midlife women living with type 2 diabetes. The gender-specific intervention fosters self-efficacy, encouraging positive wellbeing behaviours to enhance diabetes and menopause outcomes. In 2016, We co-led a feasibility trial and process evaluation with 70 women aged 45-50 years from the UK and Australia.

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Background: Sarcopenia is a progressive and generalized skeletal muscle disorder. Early diagnosis is necessary to reduce the adverse effects and consequences of sarcopenia, which can help prevent and manage it in a timely manner. The aim of this study was to identify the important risk factors for sarcopenia diagnosis and compare the performance of machine learning (ML) algorithms in the early detection of potential sarcopenia.

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Herein, we aimed to describe the outcomes of patients with blood stream infections due to carbapenem-resistant Klebsiella pneumoniae (CR-Kp) who received ertapenem plus meropenem combination treatment (EMCT). A total of 53 patients with culture proven CR-Kp bacteremia treated with ertapenem + meropenem were included. The patients with secondary bacteremia due to urinary tract infection exhibited a significantly lower 1-month mortality (OMM), particularly in those with microbiological eradication and those with end-of-treatment success.

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Article Synopsis
  • The study aimed to assess how different antimicrobial agents (CHX, ALX, and OCT) affect the bond strength of resin composites to dentin, which is important for preventing microleakage in root-filled teeth.
  • Treatment with ALX and OCT showed significant improvements in bond strength compared to CHX and saline, regardless of the type of resin composite used.
  • The results indicated that using ALX or OCT for final irrigation enhances the bonding of resin composites to dentin, with different failure modes observed based on the treatment.
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This research provides new evidence regarding the different kinds of air quality episodes, and their underlying mechanisms, that frequently impact the urban area of Quintero Bay in Central Chile, which is located along complex coastal terrain and is surrounded by industries. The monitoring campaign was carried out in January 2022 and encompassed two distinctive meteorological regimes. The first part of the month was dominated by a coastal low centered to the south of Quintero, which resulted in prevailing northerly flow (or weak southerlies) and a deep cloud-topped marine boundary layer.

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Plasmodium vivax is the most common malaria agent in the world, transmitted by vectoring of anopheles mosquitoes. In the clinical course of the disease, non-specific signs of infection (fever, myalgia, joint pain, nausea, vomiting, etc.) can be seen.

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Introduction: Secondary hemophagocytic syndrome (HPS) and systemic inflammatory response syndrome (SIRS) share similar clinical findings as a result of hyperinflammation. Due to high mortality rates in HPS; it is critical to diagnose promptly. Thus, this study aimed to evaluate the diagnostic and prognostic significance of inflammatory markers in these two increased inflammatory states.

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Purpose: The purpose of this study was to assess the pull-out bond strength (PBS) of endodontically treated anterior teeth that had been restored with monolithic zirconia endocrowns using different extension depths (EDs) and post-and-core crowns after chewing simulation.

Methods: Thirty-six maxillary central teeth were used (n = 12). Group I: Glass fiber post-and-core crown, Group II: Endocrown with 3-mm EDs, Group III: Endocrown with 5-mm EDs.

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Previous studies have shown that serum estradiol (E2) levels can predict mortality in intensive care unit patients. Our study investigated the predictive role of admission estradiol level on patient mortality and development of acute kidney injury in medical intensive care unit patients with a wide range of diagnoses. We conducted a prospective cohort study using serum samples from hospitalized patients in medical, cardiac, and pulmonary intensive care units at the Ege University Hospital within 6 months.

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Purpose: To evaluate the effect of different surface treatments, ferrule heights, and luting agents on the pull-out bond strength (PBS) of computer-aided design/computer-aided manufacturing (CAD-CAM) monolithic endocrowns.

Methods: After endodontic treatment and preparation for two endocrown designs (ferrule height 0 mm or 2 mm), CAD-CAM monolithic zirconia endocrowns were fabricated for 80 mandibular molars. Each endocrown design group was then divided on the basis of surface treatment into two groups: half were air-abraded and half were air-abraded/laser-irradiated.

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Northern sections of the Larsen Ice Shelf, eastern Antarctic Peninsula (AP) have experienced dramatic break-up and collapse since the early 1990s due to strong summertime surface melt, linked to strengthened circumpolar westerly winds. Here we show that extreme summertime surface melt and record-high temperature events over the eastern AP and Larsen C Ice Shelf are triggered by deep convection in the central tropical Pacific (CPAC), which produces an elongated cyclonic anomaly across the South Pacific coupled with a strong high pressure anomaly over Drake Passage. Together these atmospheric circulation anomalies transport very warm and moist air to the southwest AP, often in the form of "atmospheric rivers", producing strong foehn warming and surface melt on the eastern AP and Larsen C Ice Shelf.

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The aim of the study was to compare the penetration depth and percentage of Irritrol and chlorhexidine (CHX) solutions into dentinal tubules using conventional needle irrigation (CI), EDDY, and photon-induced photoacoustic streaming (PIPS). Sixty oval shaped mandibular premolar teeth were divided into two main groups according to the irrigating solutions as follows; Irritrol and CHX, which were later randomly divided into three subgroups according to the activation technique; CI, EDDY and PIPS (n = 10). Following the irrigation activation procedures, all roots were horizontally sectioned at 3 (apical), 8 (middle), and 13 (coronal) mm from the root apex and then examined with confocal laser scanning microscope (CLSM).

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Background: Irrigant activation techniques, which are more effective in anatomically complex areas, can be used to maximize irrigant efficacy.

Aim: This in vitro study aimed to evaluate the efficacy of different agitation techniques on the dislocation resistance of Biodentine to the root canal dentin.

Materials And Methods: Seventy single-rooted teeth divided into seven experimental groups (n = 10); Group I-Irritrol/Photon-induced-photoacoustic-streaming (PIPS), Group II-Irritrol/EDDY, Group III- Irritrol/Syringe-needle-irrigation (SNI), Group IV-Chlorhexidine-gluconate (CHX)/PIPS, Group V-CHX/EDDY, Group VI-CHX/SNI, Group VII-Saline.

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This study aimed to evaluate the influencing variables for outcomes in patients with septic shock having culture-proven carbapenem-resistant Gram-negative pathogens. It included 120 patients (mean age 64.29 ± 1.

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The Northern Patagonian Icefield (NPI) and the Southern Patagonian Icefield (SPI) have increased their ice mass loss in recent decades. In view of the impacts of glacier shrinkage in Patagonia, an assessment of the potential future surface mass balance (SMB) of the icefields is critical. We seek to provide this assessment by modelling the SMB between 1976 and 2050 for both icefields, using regional climate model data (RegCM4.

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Background: Hemophagocytic syndrome (HPS) ia s devastating hyperinflammatory syndrome. Heart failure (HF) with preserved ejection fraction (HFpEF) status is closely correlated with increased inflammation, both systemic and intramyocardial.

Objectives: This study sought to determine mortality predictors and reliable follow-up parameters in HPS that developed HFpEF during the clinical course.

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