[Evaluation of the influence of sex hormones on homocysteine concentration in pre- and postmenopausal women].

The aim of study was to evaluate the influence of sex hormones: estradiol (E), follicle-stimulating hormone (FSH), progesterone (P), testosterone (T), dehydroepiandrosterone (DHEA-S) and cortisol (F) on the serum homocysteine concentration (HCY) in 40 premenopausal (group M) and 80 postmenopausal (group K) women. The influence of E2 therapy (ET) on the serum HCY level in the women with surgical menopause was also estimated. The plasma HCY concentration in the group M was significantly higher that in group K.

Risk factors of cardiovascular disease in GH-deficient adults with hypopituitarism: a preliminary report.

Background: We estimated the influence of GH deficiency (GHD) in adults on chosen risk factors of cardiovascular disease and bone density.

Material/methods: Fifty-four adults (mean age: 50.4 years) with hypopituitarism were studied.

[The effect of estrogen deficiency, estrogen and estro-progestagene therapy on total plasma homocysteine and serum lipid peroxide levels in postmenopausal women].

Objectives: Elevated plasma homocysteine (Hcy) concentration is a risk factor for atherosclerosis and venous thrombosis.

Design: an observational study.

Materials And Methods: 120 healthy women were recruited and divided in two subgroups--postmenopausal women (M-80 women) and premenopausal women (40 women) with normal menstruation as control group.

[Thyroid function in organic lesions of the hypothalamo-pituitary area].

The aim of our work was the retrospective evaluation of thyroid function in patients with organic lesions of hypothalamo-pituitary system. In the group of 57 examined patients (31 females and 26 males), 43 were affected by pituitary adenomas, in the other patients organic lesions were caused by other tumors of central nervous system (2), tuberculosis (3) developmental or vascular disorders (5), nonspecific inflammation (1). Pituitary tumors (predominantly macroadenomas) were the cause of acromegaly in 14 cases, Cushing's disease in 9 and hyperprolactinaemia in 5.

[Is obesity associated with a polymorphism Pro12Ala and Pro115Gln in the PPARgamma gene?].

Unlabelled: PPARgamma is one of the pivotal factors that influence adipocyte differentiation. It is transcriptional factor that plays a crucial role in the regulation of genes involved in lipid utilisation and storage as well as insulin action. The objective of this study was to evaluate whether PPARgamma Pro12Ala and Pro115Gln polymorphisms are connected with obesity and its anthropological parameters.

[Is obesity associated with a polymorphism Pro12Ala and Pro115Gln in PPARgamma gene?].

Unlabelled: Gene PPARgamma is one of the pivotal factors that influence adipocyte differentiation. It is transcriptional factor that plays a crucial role in the regulation of genes involved in lipid utilisation and storage as well as insulin action. The aim of this study was to evaluate whether PPARgamma Pro12Ala and Pro115Gln polymorphisms are connected with obesity and its anthropological parameters.

Serum leptin levels in acromegaly--a significant role for adipose tissue and fasting insulin/glucose ratio.

Background: Leptin plays an important role in controlling satiety and maintaining energy balance. Acromegaly is characterized by decreased fat, which increases after the disease is cured. Our objective was to investigate serum leptin in acromegaly in terms of disease activity, body fat content, insulin and glucose levels, and selected anthropometric variables.