[Recurrent adenoma of the hypophysis].

Adenoma recurrences were established in 24 (9.7%) of 247 patients with operated pituitary adenomas; 7 of them were with chromophobic non-secreting adenomas, 9 patients with acromegaly, 5 female and 3 male patients were with prolactinomas. Transcranial operations were performed on patients with large-size tumors and transsphenoidal ones on patients with small-size adenomas.

[Pituitary apoplexy].

Ten patients with pituitary apoplexy were treated at the Institute of Endocrinology, Gerontology and Geriatrics in Sofia over the last 5 years. They represented 5.06% of the total number of patients with pituitary adenomas treated at the Institute during the same period.

[Principles of selection of the method of treating Itsenko-Cushing disease].

Various methods for therapy of Icenko-Cushing's disease: radiotherapeutic, surgical and medicinal were evaluated. A total of 184 patients were treated. The authors have been of opinion that therapeutic methods depended on function of the neuroendocrine system and adrenal cortex, e.

[Treatment of Cushing's syndrome with large doses of reserpine].

The effectiveness of high doses of reserpine was studied in two groups of patients, suffering from Icenko-Cushing's disease. The patients of the first group received gamma-beam therapy combined with high doses of reserpine. The patients of the second group were treated with gamma-beam radiation associated with unilateral adrenalectomy plus high doses of reserpine.

[Clinical results with a complex conservative treatment method in infiltrative ophthalmopathy (preliminary report)].

The present methods for the treatment of infiltrative ophthalmopathy are still unsatisfactory, some of them associated with considerable and lasting side effects. Clinical results are present in the communication, from the application of an original therapeutic complex, consisting in the parallel administration of ACTH, intravenous infusions, moderate doses cortison, diuretics and sanation via antibiotics and eventual surgical intervention of the existing focal infectious agents. The complex is applied in the course of 4 weeks.

[Galactorrhea and prolactin secretion in acromegaly].

Dependence of lactorrhea on the basic blood level of somatotropic hormone (STH), prolactin (PL), folliculostimulating hormone (FSH), and luteinizing hormone (LH) was studied in 62 patients with an active phase of acromegaly, untreated, and in 41 with inactive phase of the disease following radiation therapy. Thyrotropic hormone (TTH), PL, and STH secretion (basic and after intravenous injection of 200 micrograms of thyroliberin) was determined in 20 patients with active and in 6--with inactive acromegaly following radiation therapy. In patients with active acromegaly the percentage of lactorrhea in women constituted 60 and in men--9.

[Effect of heparin, heparin derivatives and heparinoids on blood sugar levels of diabetes mellitus patients].

The effect of heparin, its derivatives--sodium iodoheparinate (dioparin), diethylaminoethyltheophylline heparinate (milheparin), and also heparinoids--eleparon, "thrombo" Goltzinger and Sp-51 degrees on the blood sugar level in patients with diabetes mellitus and in healthy persons was studied. The preparations were administered by drop intravenous infusion for 4 hours in a dose corresponding to 10 000 U of heparin activity. Glycemia, lipoproteid lipase, blood lipid fractions, and blood endogenous heparin levels were studied before and after the drug administration.

[Therapeutic qualities of a lente preparation of swine insulins manufactured by Pharmachem].

The therapeutic effect of swine insulin preparation Lente, "Pharmachim" production was studied in 50 diabetics. Its hypoglycemizing activitis compared with that of standardized insulin Lente--"Novo", extract of bovine pancreas. The Bulgarian preparation was found to be very similar to the preparation Lente-Novo in its pharma-codynamic properties and could successfully be used in the diabetes melitus treatment.

[Itsenko-Cusing syndrome in hypohyseal adenoma].

A case observed at the Insitute of Endocrinology, Gerontology, and Geriatry is reported with Icenko--Cushing syndrome developed in consequence of hypophyseal adenoma. The telegammatherapy (total focal dose 4760 rads) carried out in the course of one year led to a complete regression of the developed alterations-- elimination of the redistribution of fats, restoration of the face normal colour and oval, nails and hair normalization as well as of cortisolemia and decrease in the osteoporosis degree with consolidation of the pathological fractures. Blood pressure (without hypotensive treatment) within normal values--140/90.

[The functional state of the hypothalamo-hypophyseal system in tumors of the pituitary and diencephalic area].

A study was made of 38 persons, including 25--with acromegaly, 5--with chromophobic adenomas of the hypophysis, 3--with diencephalic tumours and 5 healthy individuals. STH, TTH and ACTH were determined in the blood plasma with the aid of radioimmunological methods under basic conditions and L-DOPA loading (10 mg per 1 kg of weight) with insulin (0.10 U/kg).

[Observation of a male patient with the empty sella turcica syndrome].

One case with secondary developed syndrome of sell turcica is described, after hypophysis radiation on the occasion of acromegaly. Of special interest is the preserved tropic hypophysis secretion with a clinical picture of hypopituitarism (secondary developed hypogonadism, hypothyroidism and hypocorticism) as well as the combination with another brain neoplasm--astrocytoma.