Publications by authors named "Boyu Wang"
The gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions. Among these, gut-derived serotonin (5-hydroxytryptamine, 5-HT), synthesized from tryptophan metabolism, has been identified as a key mediator. However, it remains unclear whether specific microbial factors regulate tryptophan metabolism to influence 5-HT production and anxiety regulation.
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- Ferroptosis plays an important role in preventing cancer, but how certain genes contribute to this process is not fully understood.
- Overexpression of ELF3, combined with PTEN deficiency, promotes lung cancer by enhancing cell proliferation and inhibiting ferroptosis through the regulation of the SCL7A11 gene, a known ferroptosis inhibitor.
- In clinical observations, lower levels of PTEN and higher levels of ELF3 and SCL7A11 in lung tumors correlate with poor survival outcomes for patients, suggesting that targeting ferroptosis could be a potential therapeutic strategy.
Physics-informed neural networks (PINNs) have shown promising results in solving a wide range of problems involving partial differential equations (PDEs). Nevertheless, there are several instances of the failure of PINNs when PDEs become more complex. Particularly, when PDE coefficients grow larger or PDEs become increasingly nonlinear, PINNs struggle to converge to the true solution.
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- The study investigates the relationship between the NHHR (non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio) and cardiovascular disease (CVD) among middle-aged and older adults in China.
- Over a seven-year period, 1,139 participants developed CVD, with significant increases in risk correlating with higher NHHR ratios—98% for overall CVD, 48% for stroke, and 115% for heart issues.
- The findings suggest that higher NHHR is a key risk factor for CVD, particularly in those under 60 and with hypertension, highlighting the importance of early intervention.
The human brain has inherent limitations in consciously processing visual information. When individuals monitor a rapid sequence of images for detecting two targets, they often miss the second target (T2) if it appears within a short time frame of 200-500ms after the first target (T1), a phenomenon known as the attentional blink (AB). The neural mechanism behind the attentional blink (AB) remains unclear, largely due to the use of simplistic visual items such as letters and digits in conventional AB experiments, which differ significantly from naturalistic vision.
View Article and Find Full Text PDFHighly sensitive and quantitative detection of tumor markers is critically important for the early diagnosis and treatment of cancers. In this study, we propose a novel magnetic/photothermal dual-sensing capillary immunochromatographic assay (CICA) strategy for the sensitive detection of carcinoembryonic antigen (CEA). To achieve this, we developed a rambutan-like FeO@CuS@PDA-Au core-shell heterostructure with a high photothermal conversion efficiency of 59.
View Article and Find Full Text PDFGaining deep understanding and effective regulation of the charge transport mechanism within molecular junctions is essential for the development of electronic devices. In this work, a series of hexabenzocoronene-based single-molecule junctions are successfully constructed, and their temperature-dependent charge transport properties are studied. It is found that rotational vibrations of both benzene and hexabenzocoronene rings are sequentially excited as the temperature increases, and the electron-vibration coupling enhances charge tunneling.
View Article and Find Full Text PDFPurpose: This study aims to explore the relationship between basal metabolic rate (BMR) and cognitive impairment and assess the potential of BMR as a protective factor against cognitive decline.
Methods: This investigation initially conducted a cross-sectional study of American adults from 2011 to 2014 using data from the National Health and Nutrition Examination Survey. It examined the correlation between participants' BMR and cognitive functions, exploring the association with cognitive impairment.
Impact of Low Physical Activity on Cardiovascular Disease Across Regions and Demographic Groups: Insights from the Global Burden of Disease Study.
Eur Heart J Qual Care Clin Outcomes
November 2024
Article Synopsis
- Cardiovascular disease (CVD) is a leading global cause of death, and low physical activity (LPA) is identified as a major risk factor, with its prevalence remaining concerningly high.
- Between 1990 and 2021, deaths from CVD related to LPA increased significantly, particularly in Southeast Asia and Sub-Saharan Africa, while low-income regions saw a steady rise in disability-adjusted life years (DALYs) and years of life lost (YLLs).
- Urgent interventions are needed, especially in low- and middle-income countries, to tackle the growing health risks associated with LPA and improve public health outcomes.
Article Synopsis
- The text discusses the challenges in creating synthetic populations for geo-simulation research, particularly the lack of social networks essential for studying human interactions like disease spread and disaster response.
- It introduces a new Python method that utilizes open data, including the 2020 U.S. Census, to generate a realistic synthetic population for all 50 states and Washington D.C., complete with stylized social networks.
- This synthetic population can be used in various geo-simulation models, such as agent-based modeling, to investigate complex phenomena and enhance research on urban digital twins.
Acute myocardial infarction (AMI) remains a leading cause of death among patients with cardiovascular diseases. Percutaneous coronary intervention (PCI) has been the preferred clinical treatment for AMI due to its safety and efficiency. However, research indicates that the rapid restoration of myocardial oxygen supply following PCI can lead to secondary myocardial injury, termed myocardial ischemia-reperfusion injury (MIRI), posing a grave threat to patient survival.
View Article and Find Full Text PDFBackground: The Platelet to High-Density Lipoprotein cholesterol Ratio (PHR) is a novel indicator of inflammatory response and metabolic disorders, linked to various chronic diseases. This study aims to investigate the relationship between PHR and hypertension.
Methods: Data from the National Health and Nutrition Examination Survey (NHANES), collected across seven consecutive cycles from 2005 to 2018, were analyzed.
Background: Metabolic regulation of various amino acids have been proven to be effective in preventing cardiovascular disease (CVD). The impact of tryptophan, an essential amino acid, on the risk of developing CVD has not been fully elucidated.
Aims: The aim of this meta-analysis was to systematically review evidence of the effects of tryptophan on CVD risk.
Background: Chronic Pulmonary Heart Disease (CPHD) significantly impacts global health, especially among middle-aged and older adults. In China, the Traditional Chinese Medicine (TCM) technique of Resolving Phlegm and Activating Blood (RPAB) is widely used to treat CPHD, although high-quality evidence supporting its efficacy remains limited.
Objectives: The purpose of this study was to rigorously assess the clinical efficacy of RPAB for CPHD and elucidate the mechanisms underlying its primary herbal components.
Heart failure (HF) is closely linked to platelet counts and lipid levels. The platelet-to-high-density lipoprotein cholesterol ratio (PHR) is a novel marker for assessing cardiovascular disease. This study investigates the relationship between PHR and HF.
View Article and Find Full Text PDFObjective: This study explores the global disease burden associated with high Body Mass Index (BMI) from 1990 to 2021, using data from the Global Burden of Disease Study 2021 (GBD 2021).
Methods: We applied Joinpoint regression to assess trends in deaths and Disability-Adjusted Life Years (DALYs) and employed ARIMA models to project future BMI-related burdens.
Results: From 1990 to 2021, global deaths linked to high BMI surged by 153.
Background: Endometriosis is intricately linked to metabolic health. The Cardiometabolic Index (CMI), a novel and readily accessible indicator, is utilized to evaluate metabolic status. This study seeks to investigate the potential correlation between CMI and endometriosis.
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- The study aimed to compare the effectiveness and safety of Ankura Plus and Castor stents in treating Stanford type B aortic dissection (TBAD) with inadequate proximal anchoring from January 2020 to October 2022.
- Surgical success rates were 100% for both stents, but the Ankura Plus group had longer surgery times; no significant differences in complications like renal failure or strokes were found.
- Both stents demonstrated excellent patency rates after 12 months, suggesting they are safe and effective for TBAD treatment, but further long-term research is needed for the Ankura Plus stent.
Article Synopsis
- Iliac vein compression syndrome (IVCS) is caused by chronic pressure on the iliac vein, leading to potential complications like venous leg ulcers (VLU), but the diagnostic role of computed tomography venography (CTV) is still being explored.
- A study analyzed the medical records of 62 patients, finding that CTV delivered more thorough information than other imaging methods and that female sex and older age are significant risk factors for IVCS.
- The research indicated that patients with IVCS who received stenting showed notable improvements in both clinical symptoms and ulcer healing rates, suggesting that stenting could be a beneficial treatment option.
Introduction: Recently, Google introduced Pathways as its next-generation AI architecture. Pathways must address three critical challenges: learning one general model for several continuous tasks, ensuring tasks can leverage each other without forgetting old tasks, and learning from multi-modal data such as images and audio. Additionally, Pathways must maintain sparsity in both learning and deployment.
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- Noncovalent interactions involving aromatic rings, like π-stacking and π-ion interactions, are crucial for processes such as molecular recognition and electronics, but studying them experimentally is challenging due to their weak nature.
- The research focuses on interactions between different aromatic components and ions in a nonpolar solution, using electrical measurements and theoretical calculations, specifically looking at phenyl and pentafluorobenzyl groups with lithium and chloride ions.
- Findings indicate that heterogeneous interactions (like π···π-hole and π···cation) have stronger binding energies and longer lifetimes compared to homogeneous π···π interactions, and the nature of the ions affects the binding characteristics, providing insights for better manipulation of molecular systems.
Article Synopsis
- Electroencephalography (EEG) and Magnetoencephalography (MEG) source imaging aims to reveal the brain's active sources from recordings, but solving this inverse problem is difficult due to its complex nature.
- The paper introduces a new method called XDL-ESI, which combines deep learning and iterative optimization to create a data-driven framework that enhances source solution modeling without relying on traditional assumptions.
- Benefits of XDL-ESI include better accuracy through a topological loss for localization errors, improved reconstruction efficiency, and greater interpretability, showing strong performance in both simulated and real clinical data, particularly with simultaneous EEG and intracranial EEG (iEEG).
Objectives: Cardiometabolic Index (CMI) is a surrogate marker for metabolic disorders. It is associated with various chronic diseases. This study aims to investigate the relationship between CMI and asthma.
View Article and Find Full Text PDFAccumulating evidence supports the concept that DNA damage response targeted therapies can improve antitumor immune response by increasing the immunogenicity of tumor cells and improving the tumor immune microenvironment. Ataxia telangiectasia mutated (ATM) is a core component of the DNA repair system. Although the ATM gene has a significant mutation rate in many human cancers, including colorectal, prostate, lung, and breast, it remains understudied compared with other DDR-involved molecules such as PARP and ATR.
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