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Publications by authors named "Boyoon Lee"

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ADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity.
Yoonju Kim Sang-Eun Lee Joohyun Park Minhyung Kim Boyoon Lee

J Biol Chem

March 2015

Article Synopsis
  • Recent studies highlight a controversial role of ARF6 in dendritic spine development, with findings suggesting that its effects vary based on neuronal maturation and activity levels.
  • In developing neurons, ARF6 activation promotes spine formation, while in mature neurons, it actually reduces spine density, indicating a dual role depending on the neuronal stage.
  • The study reveals that ARF6 activation influences gene expression related to neuron structure and that both Rac1 and RhoA pathways are involved in these processes, emphasizing the importance of neuronal activity in mediating ARF6's effects on spine development.
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TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain.
Yongwoo Jang Mi Hyun Lee Jesun Lee Jooyoung Jung Sung Hoon Lee Boyoon Lee

Pflugers Arch

October 2014

Intracellular Ca(2+) signal is a key regulator of axonal growth during brain development. As transient receptor potential (TRP) channels are permeable to Ca(2+) and mediate numerous brain functions, it is conceivable that many TRP channels would regulate neuronal differentiation. We therefore screened TRP channels that are involved in the regulation of neurite growth.

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Synopsis of recent research by authors named "Boyoon Lee"

  • - Boyoon Lee's research primarily focuses on the molecular mechanisms regulating neuronal development, particularly how specific proteins and channels influence dendritic spine formation and neurite growth during different stages of neuronal maturation and activity levels.
  • - One significant finding from Lee's work indicates that ADP-ribosylation factor 6 (ARF6) has a dual role in dendritic spine development, acting positively in developing neurons but negatively in mature ones, highlighting the complexity of neuronal maturation impacts on structural alterations.
  • - Additionally, Lee's studies investigate the role of TRPM2 as a mediator for lysophosphatidic acid-induced neurite retraction, suggesting that TRP channels play an important role in intracellular calcium signaling and neuronal differentiation during brain development.

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