Comprehensive analysis of PSMG3 in pan-cancer and validation of its role in hepatocellular carcinoma.

Background: Proteasome assembly chaperone 3 (PSMG3), a subunit of proteasome, has been found to be associated with lung cancer. However, the role of PSMG3 in other cancers has not been elucidated. The objective of this study was to explore the immune role of PSMG3 in pan-cancer and confirm the oncogenic significance in liver hepatocellular carcinoma (LIHC).

A three-stage deep learning-based training frame for spectra baseline correction.

For spectrometers, baseline drift seriously affects the measurement and quantitative analysis of spectral data. Deep learning has recently emerged as a powerful method for baseline correction. However, the dependence on vast amounts of paired data and the difficulty in obtaining spectral data limit the performance and development of deep learning-based methods.

Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness.

Hematopoietic stem cells (HSCs) have reduced capacities to properly maintain and replenish the hematopoietic system during myelosuppressive injury or aging. Expanding and rejuvenating HSCs for therapeutic purposes has been a long-sought goal with limited progress. Here, we show that the enzyme Sphk2 (sphingosine kinase 2), which generates the lipid metabolite sphingosine-1-phosphate, is highly expressed in HSCs.