[Surgical treatment of secondary trigeminal neuralgia].

Objective: To present a case series analysis of surgical treatment of patients with secondary trigeminal neuralgia.

Material And Methods: The treatment of 8 patients with secondary trigeminal neuralgia who underwent surgery since 2021 was analyzed. All records, neuroimaging archive, and follow-up observations were reviewed.

[Mistakes in the diagnosis of neuromyelitis optic spectrum diseases lead to wrong therapy and deterioration of patients' condition].

Neuromyelitis optic spectrum diseases (NMOSD) are a group of rare neuroimmunological diseases involving mainly the optic nerves and spinal cord, to a lesser extent the brain, and causing severe exacerbations that lead to persistent disability of patients. For many years, opticoneuromyelitis was considered a prognostically unfavorable variant of the course of multiple sclerosis (MS), however, in 2004, specific autoantibodies to aquaporin-4 were found in such patients, which made it possible to isolate NMOSD into a separate group of demyelinating diseases other than MS. Due to similar clinical signs and the predominantly remitting course of diseases, it is often difficult to make a correct diagnosis and, accordingly, prescribe effective therapy, which often leads to incorrectly selected therapy with incorrect diagnosis.

Fusing modalities by multiplexed graph neural networks for outcome prediction from medical data and beyond.

With the emergence of multimodal electronic health records, the evidence for diseases, events, or findings may be present across multiple modalities ranging from clinical to imaging and genomic data. Developing effective patient-tailored therapeutic guidance and outcome prediction will require fusing evidence across these modalities. Developing general-purpose frameworks capable of modeling fine-grained and multi-faceted complex interactions, both within and across modalities is an important open problem in multimodal fusion.

Survival of Nematode Larvae after Treatment with Eugenol, Isoeugenol, Thymol, and Carvacrol.

Background: Helminthiases inflict annual losses on the meat and dairy livestock industries. The commonest species of ruminant parasites are the nematodes: and , which lay eggs in the intestine and enter the feces. There, the eggs develop into larvae, which when voided with the feces crawl onto plants.

[Hostility as a manifestation of attachment disorders in depression].

Objective: To analyze the relationship between hostility and attachment disorders in endogenous depression.

Material And Methods: The study included 49 patients with a diagnosis of depressive disorder, all of them completed the Simptom Check List-90-Revised (SCL-90R); the Buss-Perry Aggression Questionnaire; the Experiences in Close Relationships-Revised (ECR-R); Ich-Struktur-Test nach Ammon. The patients were assessed using the Hamilton Depression Rating Scale (HDRS-17).

Promising medicinal plants for treatment of helminths of bison.

Bison bonasus (Linnaeus, 1758) and B. bison (Linnaeus, 1758) are mammals placed in the Red Book of the International Union for Conservation of Nature. Populations of those species of animals are under threat of extinction.

High Doses of Pesticides Induce mtDNA Damage in Intact Mitochondria of Potato In Vitro and Do Not Impact on mtDNA Integrity of Mitochondria of Shoots and Tubers under In Vivo Exposure.

It is well known that pesticides are toxic for mitochondria of animals. The effect of pesticides on plant mitochondria has not been widely studied. The goal of this research is to study the impact of metribuzin and imidacloprid on the amount of damage in the mtDNA of potato ( L.

[Efficacy and safety of sampeginterferon β-1a in the treatment of relapsing remitting multiple sclerosis: results of 52 weeks of therapy in a randomized, double-blind clinical trial].

Objective: To evaluate the efficacy and safety of samPEG-IFN-β1a 180 μg and 240 μg administered once every 2 weeks for the treatment of relapsing remitting multiple sclerosis (RRMS) compared to placebo and low dose interferon beta-1a (LIB) 30 μg administered once weekly. The primary endpoint after 52 weeks of therapy was the time to first relapse, the hypotheses of non-inferiority and superiority to LIB were tested.

Material And Methods: This international, multicenter, double blind, comparative, placebo-controlled clinical study enrolled 399 patients with the diagnosis of RRMS, randomized in 4 groups: samPEG-IFN-β1a180 μg (=114), samPEG-IFN-β1a 240 μg (=114), LIB (=114) and placebo (=57).

[Dynamics of psychopathological symptoms during the COVID-19 pandemic in Russia].

Objective: The results of the analysis of psychopathological symptom dynamics during the COVID-19 pandemic in Russia are presented.

Material And Methods: The study uses the data of the Internet survey, which included a block of sociodemographic questions and the SCL-90-R symptomatic questionnaire. Nine hundred and eight responses received from 22.

[A rare clinical case of comorbidity of early-onset Parkinson's disease and remitting multiple sclerosis].

Comorbidities of extrapyramidal disorders and multiple sclerosis (MS) are rare. The chance of a combination of MS and Parkinson's disease (PD) is less than 1 in 12.5 million.

[Possibilities of art therapy and color therapy in the rehabilitation of multiple sclerosis].

The Purpose Of The Study: To study the effectiveness of non-drug methods of prevention and rehabilitation of patients with various variants of multiple sclerosis (MS) in outpatient settings.

Material And Methods: In a group of 35 patients with limited mobility with various variants of the course of MS, continuous art therapy was performed (art lectures, work with various art materials - markers, pastels, etc.).

Influence of essential oils on sporulation of Eimeria magna oocysts.

We researched the influence of essential oils from 14 species of plants (Piper cubeba, Cananga odorata, Pelargonium graveolens, Citrus sinensis, Eucalyptus globulus, Lavandula angustifolia, Picea abies, Citrus paradisi, Pterocarpus santalinus, Abies sibirica, Juniperus communis, Melaleuca alternifolia, Syzygium aromaticum and Cinnamomum verum) on the process of sporulation of Eimeria magna Perard, 1925. In the experiment we used 0.5% emulsion of oil during 72 hours, oocysts of E.

Nematicidal activity of aqueous tinctures of plants against larvae of the nematode Strongyloides papillosus.

This research was undertaken to evaluate the nematicidal activity of various concentrations of aqueous tinctures of 80 plant species towards L1-2 of S. papillosus. For the experiment with larvae of S.

Extracting and Learning Fine-Grained Labels from Chest Radiographs.

Chest radiographs are the most common diagnostic exam in emergency rooms and intensive care units today. Recently, a number of researchers have begun working on large chest X-ray datasets to develop deep learning models for recognition of a handful of coarse finding classes such as opacities, masses and nodules. In this paper, we focus on extracting and learning fine-grained labels for chest X-ray images.

Erythropoietin as an independent prognostic factor in myelodysplastic syndromes.

Aim: To assess the level of erythropoietin (EPO) in blood sera of patients with different subtypes of myelodysplastic syndromes (MDS) from different risk subgroups and to determine its prognostic role.

Materials And Methods: EPO was measured by enzyme-linked immunosorbent assay in peripheral blood of 54 patients with different MDS subtypes according to the French-American-British (FAB) classification. The comparison group consisted of 15 healthy individuals.

The effect of pesticides on the mtDNA integrity and bioenergetic properties of potato mitochondria.

Potato (Solanum tuberosum L.) is one of the most common crops in the world, and it is very susceptible to a wide range of pests such as insects and fungi. The use of pesticides often results in the suppression of seed germination and plant growth, in particular, due to their effect on the respiratory chain of mitochondria.

Comparison of Chest Radiograph Interpretations by Artificial Intelligence Algorithm vs Radiology Residents.

Importance: Chest radiography is the most common diagnostic imaging examination performed in emergency departments (EDs). Augmenting clinicians with automated preliminary read assistants could help expedite their workflows, improve accuracy, and reduce the cost of care.

Objective: To assess the performance of artificial intelligence (AI) algorithms in realistic radiology workflows by performing an objective comparative evaluation of the preliminary reads of anteroposterior (AP) frontal chest radiographs performed by an AI algorithm and radiology residents.

[Changes in the quality of life in patients with multiple sclerosis treated with ocrelizumab].

Aim: To study the quality of life (QoL) in patients with multiple sclerosis (MS) treated with ocrelizumab for at least 12 months.

Material And Methods: Thirty-eight patients were observed, including 13 with primary progressive MS (PPMS), 15 with highly active relapsing-remitting MS (HAMS) and 10 with secondary progressive MS (SPMS) with relapses. QoL was studied using unspecific SF-36 and MS-specific MusiQoL questionnaires.

[Results of a phase 1 clinical study of anti-CD20 monoclonal antibody (BCD-132): pharmacokinetics, pharmacodynamics and safety].

Aim: To study the pharmacokinetics, pharmacodynamics, and immunogenicity of two intravenous dosing regimens of the new anti-B-cells drug BCD-132 (JSC BIOCAD, Russia) at ascending doses in patients with remitting multiple sclerosis.

Material And Methods: Twenty-four patients with multiple sclerosis were sequentially randomized in the multicenter open-label uncontrolled multicohort phase I study (3+3 design) and assigned to 4 cohorts (8 groups). Patients in each cohort received an intravenous infusion of BCD-132 at a predefined dose ranging from 100 to 1000 mg based on the planned algorithm of dose escalation if no dose-limiting toxicities occurred.

Overbinding and Qualitative and Quantitative Changes Caused by Simple Na and K Ions in Polyelectrolyte Simulations: Comparison of Force Fields with and without NBFIX and ECC Corrections.

Overbinding of ions is a common and well-known problem in classical molecular dynamics simulations. One of its main causes is the absence of electronic polarizability in the force fields. The current approaches for minimizing overbinding typically either retain the original charges and use an ad hoc readjustment of the Lennard-Jones parameters as done in the nonbonded fix (NBFIX) approach or rescale the charges using a theoretical framework.

The Impact of Acids Approved for Use in Foods on the Vitality of and (Nematoda) Larvae.

The laboratory experiment described in this article evaluated the death rate of larvae of (Rudolphi, 1803) nematodes of the Strongylida order and (Wedl, 1856) of the Rhabditida order under the impact of different concentrations of 8 flavouring acids and source materials approved for use in and on foods and in medicine (formic, wine, benzoic, salicylic, stearic, kojic, aminoacetic, succinic acids). Minimum LD for third stage larvae of (L) was observed with salicylic and wine acids, for L larvae with formic acid. Minimum impact on all studied stages of development of nematodes was caused by stearic, kojic, aminoacetic and succinic acids: larvae did not die in the course of one day even at 1 % concentration of these substances.

[Influence of psychopathological factors and personality traits on the results of the study of quality of life in patients with multiple sclerosis].

Aim: To study the influence of psychopathological factors and personality traits on the results of the study of quality of life (QoL) in patients with multiple sclerosis (MS).

Material And Methods: Forty-three patients with relapsing MS were included in the study (74.4% female; mean age 33.

[Additional possible mechanisms of the action of ocrelizumab in multiple sclerosis on example of a case-report].

Anti-B-cells products, including the anti-CD20 monoclonal antibody ocrelizumab, are widely coming to multiple sclerosis (MS) therapy. Its clinical-MRI efficacy in MS with relapses as well in primary progressive MS (PPMS) was proved by three phase III clinical studies. One example of the use of ocrelizumab use in aggressive MS showed the possibility of action on the leptomeningeal folliculi, seen at contract-enhancing MRI images.

[Primary-progressive multiple sclerosis in Russia: a medical-sociological study involving patients and neurologists].

The main results of a medical-sociological study aimed at the evaluation of the level of satisfaction with treatment in patients with primary progressive multiple sclerosis (PPMS) are presented. The survey was conducted in 19 regions of the Russian Federation and involved 437 patients with confirmed diagnosis of PPMS and 80 neurologists specialized in multiple sclerosis. The research was carried out by the All-Russian Public Organization of Disabled People with Multiple Sclerosis with the participation of the Russian Committee for Treatment and Research in Multiple Sclerosis.