Publications by authors named "Boyer-Gervoise M"
Purpose: To characterize clinical profile of pediatric local anesthetic (LA) systemic toxicity (LAST) and to identify determinants of life-threatening outcomes.
Methods: Spontaneous reports notified to the French Pharmacovigilance Network were retrieved and followed by a case-by-case review, according to the following criteria: LA as suspected drug, age < 18 years, adverse drug reactions related to nervous system, cardiac, respiratory, psychiatric or general disorders. Multivariate logistic regression analysis was performed to identify factors leading to life-threatening reaction (i.
We report the case of a 4-month-old baby boy who presented hypothermia (rectal temperature 36°C) after acetaminophen intake for post-vaccination fever. A recurrence of the hypothermia was observed after acetaminophen rechallenge for fever. We reviewed 14 other pediatric cases of hypothermia secondary to therapeutic doses of acetaminophen.
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- The study reports pediatric cases of serious respiratory adverse drug reactions (ADRs) linked to oral mucolytic drugs, leading to their market withdrawal for infants in France and Italy.
- The analysis, conducted from 1989 to 2008, involved voluntarily reported cases of children experiencing paradoxical respiratory issues after using these drugs.
- Findings revealed that the majority of affected infants, mostly under 2 years old, required hospitalization for conditions like increased mucus production and worsening respiratory distress, suggesting significant safety concerns with these medications.
[Are IVF results predictable through the analysis of sperm DNA fragmentation?].
Gynecol Obstet Fertil
December 2003