Evaluation of an alternative skeletal muscle index for skeletal muscle mass assessment in a group of Australian women.

Background: Sarcopenia is assessed by several methods, including dual energy X-ray absorptiometry (DEXA), which provide a height-adjusted skeletal muscle index (H-SMI). A SMI 2 standard deviation below the young adult reference [1] combined with low muscle strength or performance is used to identify sarcopenia. As height declines with age, H-SMI may underestimate low skeletal muscle mass in the older population.

Mental health diagnoses in adults with phenylketonuria: a retrospective systematic audit in a large UK single centre.

Background: Recently published European Society for Phenylketonuria (ESPKU) guidelines have recommended a lifelong diet with phenylalanine (Phe) control ≤ 600 μmol/L for phenylketonuria (PKU) patients. This study aimed to identify whether PKU adult patients are at a higher risk of mental health diagnoses if their 2-year average Phe level is higher than the ESPKU European guidelines. Published studies identified by a literature review showed that related studies have been published in American and European PKU study populations but not in the United Kingdom (UK) study populations.

Multicomponent density models for body composition: Review of the dual energy X-ray absorptiometry volume approach.

Accurate and precise body composition estimates, notably of total body adiposity, are a vital component of in vivo physiology and metabolic studies. The reference against which other body composition approaches are usually validated or calibrated is the family of methods referred to as multicomponent "body density" models. These models quantify three to six components by combining measurements of body mass, body volume, total body water, and osseous mineral mass.

Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy.

Context: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walking. Rodent models of ADT have demonstrated that the levator ani is exquisitely androgen sensitive.

Objective: To determine whether the high androgen responsiveness of the levator ani muscle documented in rodents is evolutionarily conserved and ADT is associated with a selective loss in leg muscle volume.

Body composition analysis using abdominal scans from routine clinical care in patients with Crohn's Disease.

Objective: Crohn's Disease is associated with body composition changes, which have important treatment and prognostic implications. Measurement of body composition usually requires dedicated scanning or measurement, with retrospective analysis of existing datasets impossible. We sought to determine whether single slice analysis of abdominal scans, obtained during routine clinical care, in patients with Crohn's Disease accurately predicts body composition compartments.

Measuring visceral fat, subcutaneous fat and skeletal muscle area changes by computed tomography in acute pancreatitis: a retrospective, single-centre study.

Objective: To show that body composition of intensive care unit patients can be analysed with existing computed tomography (CT) images. We planned to describe changes in visceral fat area (VFA), subcutaneous fat area (SFA) and muscle area (MA) on analysis of specific CT images during acute pancreatitis requiring an ICU admission.

Design, Setting And Participants: Retrospective analysis of body composition using existing CT images, in an ICU of a tertiary university-affiliated hospital 2005-2010, examining 21 patients with acute pancreatitis and CT imaging on two separate occasions within their hospital admission.

Fat-free mass depletion in cystic fibrosis: associated with lung disease severity but poorly detected by body mass index.

Objective: Malnutrition in cystic fibrosis (CF) is associated with poorer survival, but the determinants of fat-free mass (FFM) depletion are not well-characterized. It is unknown whether routine nutritional indicators, including body mass index (BMI), are adequate for detecting FFM depletion. This study aimed to determine the prevalence of FFM depletion in adults with CF, to compare fat-free mass index (FFMI) with BMI, and to identify predictors of FFM depletion.

Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality.

To investigate the role of androgens in increasing bone density and improving low libido in postmenopausal women, we have studied the long-term effects of estradiol and testosterone implants on bone mineral density and sexuality in a prospective, 2 year, single-blind randomised trial. Thirty-four postmenopausal volunteers were randomised to treatment with either estradiol implants 50 mg alone (E) or estradiol 50 mg plus testosterone 50 mg (E&T), administered 3-monthly for 2 years. Cyclical oral progestins were taken by those women with an intact uterus.

Smaller hip circumference is associated with dyslipidemia and the metabolic syndrome in obese women.

Background: There is great need for simple anthropometric measures that predict risk. The authors explored the relationship between body composition measures and features of the metabolic syndrome (MtS) in women aged between 20 and 50 years with class I obesity.

Methods: This is a cross-sectional study of 49 obese (BMI 30-35) women recruited into a weight management randomized trial.

Body composition of children with chronic and end-stage renal failure.

Aim: Protein energy malnutrition is common in children with chronic renal failure (CRF) and may negatively impact on clinical outcome. Although the aetiology of malnutrition is multifactorial, descriptive information on body composition may guide nutritional interventions aimed at optimising nutritional status.

Methods: This prospective cohort study in children with CRF was conducted from April 1999 to November 2000.

Changes in body composition with weight loss: obese subjects randomized to surgical and medical programs.

Objective: To assess changes in body composition with weight loss in obese subjects randomized to a laparoscopic adjustable gastric band surgical program or a medical program using a very-low-energy diet and orlistat.

Research Methods And Procedures: Using body composition measurements by DXA, neutron activation for total body nitrogen, and whole body gamma counting for total body potassium, we studied changes in fat mass, fat distribution, fat-free mass, total bone mineral content, total body protein, and body cell mass at 6 (n = 61 paired) and 24 months (n = 53 paired) after randomization.

Results: At 24 months, the surgical group had lost significantly more weight (surgical, 20.

Single frequency bioelectrical impedance is a poor method for determining fat mass in moderately obese women.

Background: The primary aim of weight loss intervention in obesity is the loss of fat mass (FM). Hence, determinations of changes in FM and fat free mass (FFM) during weight loss are of clinical value. The authors compared the clinical utility of SkinFold Thickness (SKF), tetrapolar bioelectrical impedance analysis (BIA) and a body mass index (BMI) based calculation, in determining changes in percentage of fat mass (delta%FM).

Near normalisation of lumbar spine bone density in young women with osteopenia recovered from adolescent onset anorexia nervosa: a longitudinal study.

To investigate the effect of the progression of adolescent onset anorexia nervosa (AN) on bone parameters we followed two cohorts (Disease cohort and recovered cohort) of adolescents for a total of 5.2 years. In the 'Disease' cohort (n = 18), lumbar spine bone density (BMD) was reduced by 0.

The relationship between body composition and knee cartilage volume in healthy, middle-aged subjects.

Objective: Although obesity is widely accepted as a risk factor for knee osteoarthritis, it is not clear whether individual components of body composition, such as the mass and distribution of muscle and fat, are associated with development of the disease. This study examined the effect of measures of body composition on the longitudinal change in tibial cartilage volume.

Methods: Body composition, assessed via dual x-ray absorptiometry, and tibial cartilage volume, assessed via magnetic resonance imaging, were measured in 86 healthy men and women who were mid-life in age.

Determination of maternal body composition in pregnancy and its relevance to perinatal outcomes.

Three models and 10 specific methods for determining maternal body composition are discussed and their perinatal relevance reviewed. English language publications (1950 to January 2004) were searched electronically and by hand. Search terms included "body composition," "human," " pregnancy," "obesity," "adiposity," "regional," "2-, 3-, 4-component," "truncal," "peripheral," "central," "visceral" along with specific techniques and outcomes listed subsequently.

Dietary carotenoid intake as a predictor of bone mineral density.

Our understanding of the influence of nutrition on bone health is limited because most studies concentrate on the role of calcium and protein, while other nutrients receive less attention. Recent evidence shows a positive link between fruit and vegetable consumption and bone health. In the present study, the relationships of dietary intakes of preformed retinol and carotenoids, one group of phytonutrients abundant in fruit and vegetables, were examined in an Anglo-Celtic Australian population of 68 men and 137 women.