Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan.

As the elderly population expands, the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly crucial. As an FDA-approved drug for chronic cholestatic liver diseases, tauroursodeoxycholic acid (TUDCA), a natural bile acid, offers additional health benefits beyond liver protection. Here, we show that TUDCA extends the lifespan and healthspan of C.

Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.

Dendritic cells (DCs) are crucial in initiating and shaping both innate and adaptive immune responses. Clinical studies and experimental models have highlighted their significant involvement in various autoimmune diseases, positioning them as promising therapeutic targets. Nicotinamide (NAM), a form of vitamin B3, with its anti-inflammatory properties, has been suggested, while the involvement of NAM in DCs regulation remains elusive.

Mirror Symmetry Broken of Sound Vortex Transmission in a Single Passive Metasurface via Phase Coupling.

Asymmetric transmission in a passive vortex system is highly desirable, as it enables the development of compact vortex-based devices. However, breaking the mirror symmetry of transmission via a single metasurface poses challenges due to the inherent symmetric transmission properties in reciprocity. Here, we theoretically propose and experimentally demonstrate a novel transmission-reflection phase coupling mechanism to achieve the broken mirror symmetry of sound vortex transmission.

LSTMAtU-Net: A Precipitation Nowcasting Model Based on ECSA Module.

Precipitation nowcasting refers to the use of specific meteorological elements to predict precipitation in the next 0-2 h. Existing methods use radar echo maps and the Z-R relationship to directly predict future rainfall rates through deep learning methods, which are not physically constrained, but suffer from severe loss of predicted image details. This paper proposes a new model framework to effectively solve this problem, namely LSTMAtU-Net.

An interaction between β'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.

The essential COPI coat mediates retrieval of transmembrane proteins at the Golgi and endosomes following recruitment by the small GTPase, Arf1. ArfGAP proteins regulate COPI coats, but molecular details for COPI recognition by ArfGAPs remain elusive. Biochemical and biophysical data reveal how β'-COP propeller domains directly engage the yeast ArfGAP, Glo3, with a low micromolar binding affinity.

Neuromorphic functions with a polyelectrolyte-confined fluidic memristor.

Reproducing ion channel-based neural functions with artificial fluidic systems has long been an aspirational goal for both neuromorphic computing and biomedical applications. In this study, neuromorphic functions were successfully accomplished with a polyelectrolyte-confined fluidic memristor (PFM), in which confined polyelectrolyte-ion interactions contributed to hysteretic ion transport, resulting in ion memory effects. Various electric pulse patterns were emulated by PFM with ultralow energy consumption.

Improved mammalian retromer cryo-EM structures reveal a new assembly interface.

Retromer (VPS26/VPS35/VPS29 subunits) assembles with multiple sorting nexin proteins on membranes to mediate endosomal recycling of transmembrane protein cargoes. Retromer has been implicated in other cellular processes, including mitochondrial homeostasis, nutrient sensing, autophagy, and fission events. Mechanisms for mammalian retromer assembly remain undefined, and retromer engages multiple sorting nexin proteins to sort cargoes to different destinations.

Perspective on Nanofluidic Memristors: From Mechanism to Application.

Nanofluidic memristors are memory resistors based on nanoconfined fluidic systems exhibiting history-dependent ion conductivity. Toward establishing powerful computing systems beyond the Harvard architecture, these ion-based neuromorphic devices attracted enormous research attention owing to the unique characteristics of ion-based conductors. However, the design of nanofluidic memristor is still at a primary state and a systematic guidance on the rational design of nanofluidic system is desperately required for the development of nanofluidic-based neuromorphic devices.

Ubiquitination drives COPI priming and Golgi SNARE localization.

Deciphering mechanisms controlling SNARE localization within the Golgi complex is crucial to understanding protein trafficking patterns within the secretory pathway. SNAREs are also thought to prime coatomer protein I (COPI) assembly to ensure incorporation of these essential cargoes into vesicles, but the regulation of these events is poorly understood. Here, we report roles for ubiquitin recognition by COPI in SNARE trafficking and in stabilizing interactions between Arf, COPI, and Golgi SNAREs in .

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.

The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset Parkinson’s disease, while viral and bacterial pathogens can hijack the complex during cellular infection. To modulate and probe its function, we have created a novel series of macrocyclic peptides that bind retromer with high affinity and specificity.

Tunable dual-band and high-quality-factor perfect absorption based on VO-assisted metasurfaces.

Perfect absorbers with high quality factors (Q-factors) are of great practical significance for optical filtering and sensing. Moreover, tunable multiwavelength absorbers provide a multitude of possibilities for realizing multispectral light intensity manipulation and optical switches. In this study, we demonstrate the use of vanadium dioxide (VO)-assisted metasurfaces for tunable dual-band and high-quality-factor perfect absorption in the mid-infrared region.

A Visualization Approach for Monitoring Order Processing in E-Commerce Warehouse.

The efficiency of warehouses is vital to e-commerce. Fast order processing at the warehouses ensures timely deliveries and improves customer satisfaction. However, monitoring, analyzing, and manipulating order processing in the warehouses in real time are challenging for traditional methods due to the sheer volume of incoming orders, the fuzzy definition of delayed order patterns, and the complex decision-making of order handling priorities.

The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.

Arf GTPase activating (ArfGAP) proteins are critical regulatory and effector proteins in membrane trafficking pathways. Budding yeast contain two ArfGAP proteins (Gcs1 and Glo3) implicated in COPI coat function at the Golgi, and yeast require Glo3 catalytic function for viability. A new X-ray crystal structure of the Glo3 GAP domain was determined at 2.

Dirac points and the transition towards Weyl points in three-dimensional sonic crystals.

A four-fold-degenerate three-dimensional (3D) Dirac point, represents a degenerate pair of Weyl points carrying opposite chiralities. Moreover, 3D Dirac crystals have shown many exotic features different from those of Weyl crystals. How these features evolve from 3D Dirac to Weyl crystals is important in research on 3D topological matter.

Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.

Metazoan retromer (VPS26/VPS35/VPS29) associates with sorting nexins on endosomal tubules to sort proteins to the trans-Golgi network or plasma membrane. Mechanisms of metazoan retromer assembly remain undefined. We combine single-particle cryoelectron microscopy with biophysical methods to uncover multiple oligomer structures.

Experimental Realization of Type-II Weyl Points and Fermi Arcs in Phononic Crystal.

Weyl points (WPs), as the doubly degenerate points in three-dimensional momentum band structures, carry quantized topological charges and give rise to a variety of extraordinary properties, such as robust surface wave and chiral anomaly. Type-II Weyl semimetals, which have conical dispersions in Fermi surfaces and a strongly tilted dispersion with respect to type I, have recently been proposed in condensed-matter systems and photonics. Although the type-II WPs have been theoretically predicted in acoustics, the experimental realization in phononic crystals has not been reported so far.

Coding Acoustic Metasurfaces.

Coding acoustic metasurfaces can combine simple logical bits to acquire sophisticated functions in wave control. The acoustic logical bits can achieve a phase difference of exactly π and a perfect match of the amplitudes for the transmitted waves. By programming the coding sequences, acoustic metasurfaces with various functions, including creating peculiar antenna patterns and waves focusing, have been demonstrated.

Generation of vector beams with arbitrary spatial variation of phase and linear polarization using plasmonic metasurfaces.

A novel method is proposed to generate vector beams with arbitrary spatial variation of phase and linear polarization at the nanoscale using compact plasmonic metasurfaces with rectangular nanoapertures. The physical mechanism underlying the simultaneous control of light polarization and phase is explained. Vector beams with different spiral phasefronts are obtained by manipulating the local orientation and geometric parameters of the metasurfaces.