Multi-Omics Analysis Reveals the Negative Effects of High-Concentrate Diets on the Colonic Epithelium of Dumont Lambs.

Feeding HC diets has been found to induce metabolic dysregulation in the colon. However, the mechanisms by which changes in colonic flora and metabolites damage the colonic epithelium are poorly studied. Therefore, the present experiment used a multi-omics technique to investigate the mechanism of colonic injury induced by high-concentrate diets in lambs.

Visible-Thermal Tiny Object Detection: A Benchmark Dataset and Baselines.

Visible-thermal small object detection (RGBT SOD) is a significant yet challenging task with a wide range of applications, including video surveillance, traffic monitoring, search and rescue. However, existing studies mainly focus on either visible or thermal modality, while RGBT SOD is rarely explored. Although some RGBT datasets have been developed, the insufficient quantity, limited diversity, unitary application, misaligned images and large target size cannot provide an impartial benchmark to evaluate RGBT SOD algorithms.

Recessive genetic contribution to congenital heart disease in 5,424 probands.

Variants with large effect contribute to congenital heart disease (CHD). To date, recessive genotypes (RGs) have commonly been implicated through anecdotal ascertainment of consanguineous families and candidate gene-based analysis; the recessive contribution to the broad range of CHD phenotypes has been limited. We analyzed whole exome sequences of 5,424 CHD probands.

Deferasirox Targets TAOK1 to Induce p53-Mediated Apoptosis in Esophageal Squamous Cell Carcinoma.

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a poor prognosis and limited effective treatment options. This study investigates the therapeutic potential of Deferasirox (DFO), an iron chelator, in ESCC by targeting TAOK1, an STE20-type kinase implicated in cancer development. We demonstrate that DFO significantly inhibits the proliferation and colony formation of ESCC cells in a dose- and time-dependent manner.

Proton Relay in Hydrogen-Bond Networks Promotes Alkaline Hydrogen Evolution Electrocatalysis.

Common O-/H-down orientation of HO molecules on electrocatalysts brings favorable OH/H delivery; however, adverse H/OH delivery in their dissociation process hampers the HO dissociation kinetics of the alkaline hydrogen evolution reaction (HER). To overcome this challenge, we raised a synergetic HO dissociation concept of metal-supported electrocatalysts involving efficient OH delivery from O-down HO to the metal, timely proton relay from O-down HO on the metal to H-down HO on the support through the hydrogen-bond network, and prompt H delivery from H-down HO to the support. After theoretically profiling that a high work function difference between the metal and the support (ΔΦ) induces a strong electric field at the metal-support interface that increases hydrogen-bond connectivity to promote proton relay, we practiced this concept over cobalt phosphide-supported ruthenium (Ru/CoP) catalysts with a high ΔΦ = 0.

Association between genetic prediction of 486 blood metabolites and the risk of idiopathic pulmonary fibrosis: A mendelian randomization study.

Metabolic disorders are a significant feature of fibrotic diseases. Nevertheless, the lack of sufficient proof regarding the cause-and-effect association between circulating metabolites and the promotion or prevention of idiopathic pulmonary fibrosis (IPF) persists. To assess the causal association between IPF and genetic proxies of 486 blood metabolites, a dual sample Mendelian randomization (MR) analysis was performed.

Image reconstruction of electromagnetic tomography based on generative adversarial network with spectral normalization and improved dung beetle optimization algorithm.

Electromagnetic tomography (EMT) has great application potential in fields such as industrial inspection. However, currently, EMT image reconstruction has problems of being highly nonlinear and ill-posed, resulting in artifacts in reconstructed images and uncertainties in quality, detail accuracy, and robustness. To address these challenges, a deep learning model STDBOGAN (generative adversarial network based on spectral normalization, two timescale update rule, and improved dung beetle optimization algorithm) based on generative adversarial networks is proposed.

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.

Background: Cellular senescence, a hallmark of aging, has been implicated in Alzheimer's disease (AD) pathogenesis. Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis, and its expression and trafficking are altered in APOE4 and AD models.

Response mechanism of water status and photosynthetic characteristics of under drought stress and rehydrated conditions.

Introduction: Plant physiology response and adaptation to drought stress has become a hotspot in plant ecology and evolution. possesses high ecological, ornamental and economic benefits. It has large root system and tolerance to cold, drought and poor soil.

Genome-Wide Identification and Expression Analysis of PkNRT Gene Family in Korean Pine ().

The utilization of nitrogen (N) is crucial for the optimal growth and development of plants. As the dominant form of nitrogen in temperate soil, nitrate (NO) is absorbed from the soil and redistributed to other organs through NO transporters (NRTs). Therefore, exploration of the role of NRTs in response to various NO conditions is crucial for improving N utilization efficiency (NUE).

TDCPP promotes apoptosis and inhibits the calcium signaling pathway in human neural stem cells.

Tris (1, 3-dichloro-2-propyl) phosphate (TDCPP) is an extensively used organophosphorus flame retardant (OFR). Previous studies have suggested that it has neurotoxic effects, but the neurotoxicity mechanism is still unclear. Neural stem cells are an important in vitro model for studying the neurotoxicity mechanism of pollutants.

Annexin A1: The dawn of ischemic stroke (Review).

Ischemic stroke is a prevalent clinical condition that poses a significant global challenge. Developing innovative strategies to address this issue is crucial. Annexin A1 (ANXA1), a key member of the annexin superfamily, performs various functions, such as inhibiting inflammatory factor release, promoting phagocytosis, and blocking leukocyte migration.

JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1/PGC-1α/mitophagy axis in hypertensive nephropathy.

Introduction: With the increasing prevalence of hypertension, the incidence of kidney diseases is also increasing, resulting in a serious public burden. Jiangya Tongluo decoction (JYTL), a recognized prescription in traditional Chinese medicine (TCM), is commonly used to calm an overactive liver and reduce excess yang, while also promoting blood flow to alleviate obstructions in the meridians. Previous research has indicated that JYTL may help mitigate kidney damage caused by hypertension; however, the underlying mechanisms have not been thoroughly assessed.

The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation.

Background And Objective: Chronic prostatitis (CP) is a condition markered by persistent prostate inflammation, yet the specific cytokines driving its progression remain largely undefined. This study aims to identify key cytokines involved in CP and investigate their role in driving inflammatory responses through mechanistic and therapeutic exploration.

Methods: A 48-cytokine panel test was conducted to compare the plasma cytokine profiles between participants with CP-like symptoms (CP-LS) and healthy controls.

Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease.

Cellular senescence is a major contributor to aging-related degenerative diseases, including Alzheimer's disease (AD) but much less is known on the key cell types and pathways driving mechanisms of senescence in the brain. We hypothesized that dysregulated cholesterol metabolism is central to cellular senescence in AD. We analyzed whole transcriptomic data and utilized single-cell RNA seq integration techniques to unveil the convoluted cell-type-specific and sub-cell-type-state-specific senescence pathologies in AD using both ROSMAP and Sea-AD datasets.

Longitudinal Analysis of Antibody Dynamics in Severe Fever with Thrombocytopenia Syndrome Patients - High-Incidence Regions of China, 2010-2023.

What Is Already Known About This Topic?: Severe fever with thrombocytopenia syndrome (SFTS) is a serious tick-borne disease in East Asia with high mortality, particularly affecting the elderly. Since its discovery in 2010, inconsistencies in small-scale studies and the lack of decade-long research on antibody levels in large population samples after natural infection, along with the absence of an effective vaccine, highlight the need for large-scale, long-term data in high-incidence regions of China.

What Is Added By This Report?: This study of 1,410 serum samples from SFTS patients in high-incidence regions of China reveals that immunoglobulin M (IgM) levels peak at 8-14 days post-infection, declining to nearly undetectable levels by 180 days.

Optimization of efficiency of short-pulsed fast flow CO laser amplifier with dual-band and multispectral lines.

In this paper, we optimize the amplification efficiency of a nanosecond pulse CO laser in a fast flow amplifier using dual-band and multispectral lines techniques. Utilizing a six-temperature model and a random rotational relaxation model, we simulate the time-domain amplification process of dual-band and multispectral lines short-pulse seeds in a fast flow CO laser amplifier, analyzing the effects of input pulse fluence, pulse width, and spectral line composition on amplification efficiency. Compared to single-line 10P(20) amplification, the extraction efficiency of 10.

Revisiting tuberculosis as a cause of gastric outlet obstruction: Insights from a case report.

Gastroduodenal tuberculosis (GD-TB) is exceptionally rare. The clinical manifestations of gastrointestinal TB are diverse and non-specific, which makes diagnosis difficult, leading to delayed diagnosis and high mortality. As a peer-reviewer of , I would like to share my opinion on the article published by this journal.

Concentrated C Alcohol Production Enabled by Post-Intermediate Modulation and Augmented CO Adsorption in CO Electrolysis.

The electrocatalytic synthesis of multicarbon products from CO/CO feedstock represents a sustainable method for chemical production with a reduced carbon footprint. Traditional copper catalysts predominantly produce alkenes, but generating valuable and versatile C alcohols, especially high-energy-density C alcohols, has been challenging due to issues with selectivity, activity, and stability. Here, we present the construction of Ru-doped Cu nanowires that enhance the selectivity of -PrOH and C alcohols.

Surface Self-Diffusion Induced Sintering of Nanoparticles.

Despite the critical role of sintering phenomena in constraining the long-term durability of nanosized particles, a clear understanding of nanoparticle sintering has remained elusive due to the challenges in atomically tracking the neck initiation and discerning different mechanisms. Through the integration of in situ transmission electron microscopy and atomistic modeling, this study uncovers the atomic dynamics governing the neck initiation of Pt-Fe nanoparticles via a surface self-diffusion process, allowing for coalescence without significant particle movement. Real-time imaging reveals that thermally activated surface morphology changes in individual nanoparticles induce significant surface self-diffusion.

Toxicological Effects and Mechanisms of 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) on Marine Organisms.

2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is a widely used brominated flame retardant belonging to persistent organic pollutants (POPs). After being released into the marine environment, BDE-47 can cause a range of toxic effects on marine organisms through bioaccumulation, biomagnification, and intergenerational transmission. These effects include lethality, impaired motility, photosynthetic toxicity, immune damage, liver toxicity, developmental impairments, and reproductive toxicity.

The correlation of the liquidus curves and valence electron structures of a ternary lithium halide molten-salt electrolyte for liquid metal batteries.

Liquid metal batteries have received considerable attention owing to their excellent properties. However, an electrolyte with low melting temperature is required to decrease operating temperature for the safety of liquid metal batteries and for saving energy. For revealing the mechanism of low liquefaction temperature, an empirical electron theory of solid molecules was used to study the thermal properties of pure lithium halides and their ternary-phase systems systematically.