Efficient degradation of tetracycline residues in pharmaceutical wastewater by Ni/Fe bimetallic atomic cluster composite catalysts with enhanced electron transfer pathway.

Metal cluster catalysts have large atomic load, interaction between atomic sites, and wide application of catalysis. In this study, a Ni/Fe bimetallic cluster material was prepared by a simple hydrothermal method and used as an efficient catalyst to activate the degradation system of peroxymonosulfate (PMS), which showed nearly 100% tetracycline (TC) degradation performance over a wide pH range (pH = 3-11). The results of electron paramagnetic resonance test, quenching experiment and density functional theory (DFT) calculation show that the non-free radical pathway electron transfer efficiency of the catalytic system is effectively improved, and a large number of PMS are captured and activated by high density Ni atomic clusters in Ni/Fe bimetallic clusters.

Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF‑β/SMAD3 and IL‑6/STAT3 signaling pathways.

Treatment of human estrogen receptor (ER)‑positive breast cancer (ER+ BC) using conventional chemotherapy remains a challenge and is often ineffective as a result of tumor metastasis. The present study aimed to investigate the ability of narasin, an ionophore antibiotic, to potentially inhibit tumor metastasis and growth in human ER+ BC. Narasin was found to have significant inhibitory abilities on cell proliferation, migration and invasion in ER+ BC cell lines MCF‑7 and T47D compared with the triple‑negative BC cell MDA‑MB‑231.

Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway.

Background: Limonin is one of the major active ingredients of citrus. In the present study, the anti-angiogenic and anti-metastatic effects of limonin were investigated.

Methods: The Molecular docking assay was carried out to assess the binding ability of limonin with VEGFR2 receptor.

Pracinostat (SB939), a histone deacetylase inhibitor, suppresses breast cancer metastasis and growth by inactivating the IL-6/STAT3 signalling pathways.

Aims: Histone deacetylases inhibitors have shown favorable antitumor activity in clinical investigations. In the present study, we assessed the effects of a novel hydroxamic acid-based HDAC inhibitor, SB939, on breast cancer metastasis and tumor growth and characterized the underlying molecular mechanisms.

Main Methods: MTS, Wound-healing, and Transwell chamber invasion assays were used to detect the inhibition effects of SB939 on proliferation, migration, and invasion of breast cancer cells.