Optimization of target grouping in distributive stereotactic radiosurgery using the excel evolutionary solver.

Purpose: Distributive stereotactic radiosurgery (dSRS) is a form of fractionation where groups of metastases are treated with a full single-fraction dose on different days. The challenge with dSRS is determining optimal target groupings to maximize the distance between targets treated in the same fraction. This study aimed to develop and validate an accessible optimization technique for distributing brain metastases into optimal treatment fractions using a genetic algorithm.

Point-of-care ultrasound diagnosis of acute valvular emergencies.

Introduction: Acute valvular emergencies, a time-sensitive diagnosis, are nearly impossible to diagnose without ultrasound, and missing the diagnosis can significantly impact patient outcomes. Many emergency physicians lack access to echo technicians and may be uncomfortable performing the ultrasound themselves. Approaching the paucity of review articles, none of which are focused for the emergency physician, can be quite daunting, even for those with extensive ultrasound training.

Predictors of household drinking water E. coli contamination: Population-based results from rural areas of Ghana, Malawi, Mozambique, Niger, Rwanda, Uganda, and Zambia.

Background: In sub-Saharan Africa, rural areas have lower rates of access to safe drinking water compared to urban areas. We investigated predictors of Escherichia coli contamination in drinking water of rural households in Ghana, Malawi, Mozambique, Niger, Rwanda, Uganda, and Zambia.

Methods: We used a population-based, cluster randomized sampling design to select rural households in each country.

Ultrasound-Guided Nerve Blocks for Flexor Tenosynovitis.

Performing an ultrasound-guided nerve block (UGNB) is now common practice in many emergency departments (EDs) and is considered a core skill according to the American College of Emergency Physicians (ACEP). Nerve blocks are mostly utilized for fractures and laceration repairs, however, these blocks have many other applications. We present a case of utilizing an ulnar UGNB in a patient with flexor tenosynovitis and a history of intravenous drug use (IVDU) when parental opiates proved to be ineffective.

A predictive model for Gamma Knife intermediate dose spill: R50%.

Purpose: Minimizing intermediate dose spill in stereotactic radiosurgery (SRS) for brain treatment is crucial. Intermediate dose spill correlates with the exposure of normal brain tissue to high doses, which increases the risk of radionecrosis. R50%, defined as the volume of the 50% of prescription isodose cloud/planning target volume, is one metric for intermediate dose spill.

Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.

Toxins TcdA and TcdB are the main virulence factors of Clostridioides difficile, a leading cause of hospital-acquired diarrhea. Despite their importance, there is a significant knowledge gap of druggable targets for inhibiting toxin production. To address this, we screened nonantibiotic phytochemicals to identify potential chemical genetic probes to discover antivirulence drug targets.

COVID-19 Knowledge Among Sexual and Gender Minority Adults in New York City.

This study describes sources of COVID-19 vaccine information and COVID-19 knowledge among sexual and gender minority (SGM) adults in New York City (NYC). A sample of 986 SGM adults in NYC completed an online survey between June 25 and December 1, 2021. Participants indicated their top three sources of COVID-19 vaccine information from a list of 10 options.

Development of a Scoring Rubric Assessing Medical Students' Explanations of Pathology Reports.

Context.—: With increasing availability of immediate patient access to pathology reports, it is imperative that all physicians be equipped to discuss pathology reports with their patients. No validated measures exist to assess how pathology report findings are communicated during patient encounters.

Bystander intervention for problematic alcohol use among graduate and international students: opportunities and challenges.

Objectives: Bystander intervention (BI) is a prevention approach commonly used for interpersonal violence, but is less studied for problematic alcohol use (PAU). Domestic graduate and international students' life experiences bring a unique context for the potential application of BI to PAU.

Methods And Measures: We conducted a mixed methods study that consisted of a needs assessment and focus groups at a southeastern university in the U.

Psychometric Properties of the Brief Resilience Scale Among Alternative Sexuality Community Members.

Assessing resilience among alternative sexuality (alt-sex; e.g., kink, polyamory) community members is imperative as alt-sex individuals often face discrimination and possess intersecting marginalized identities.

A plague passing over: Clinical features of the 2022 mpox outbreak in patients of color living with HIV.

Introduction: Compared with previous geographically localized outbreaks of monkeypox (MPOX), the scale of the 2022 global mpox outbreak has been unprecedented, yet the clinical features of this outbreak remain incompletely characterized.

Methods: We identified patients diagnosed with mpox by polymerase chain reaction (PCR; n = 36) from July to September 2022 at a single, tertiary care institution in the USA. Demographics, clinical presentation, infection course, and histopathologic features were reviewed.

A pilot study of the adverse childhood experiences-dimensions questionnaire (ACE-DQ): Associations with depression.

Background: Recent ACE research proposed items to assess ACE dimensions, such as the frequency or timing of adverse events, that can be added to the original ACE-Study Questionnaire.

Objective: The goal of our study was to pilot-test the refined ACE-Dimensions Questionnaire (ACE-DQ) to determine its predictive validity and compare scoring approaches.

Participants And Setting: Cross-sectional online survey via MTurk with U.

Dermoscopic Findings in Intraepidermal Carcinoma: an Interobserver Agreement Study.

Introduction: A wide range of descriptive terms have been used for dermoscopic findings in intraepidermal carcinoma (IEC) and the clinical diagnostic accuracy of IEC can be challenging. Furthermore, dermoscopic findings in IEC have only rarely been evaluated in fair-skinned populations.

Objectives: To measure the interobserver agreement between dermatologists for dermoscopic findings in IEC.

Coming together in a digital age: Community twitter responses in the wake of a campus shooting.

Campus mass shootings have become a pressing policy and public health matter. Twitter is a platform used for processing events among interested community members. Examining the responses of invested community members to a mass shooting on a college campus provides evidence for how this type of violence affects the immediate community and the larger public.

Disclosing and Reporting of Consent Violations Among Kink Practitioners in the United States.

Kink practitioners are marginalized and experience adverse health and social outcomes, which are exacerbated by consent violations. This study aims to understand experiences of reporting consent violations within a kink context. Kink practitioners ( = 2,888) completed a survey focused on consent violations, reporting, and recommendations, with 767 (25.