The effect of seeing scientists as intellectually humble on trust in scientists and their research.

Public trust in scientists is critical to our ability to face societal threats. Here, across five pre-registered studies (N = 2,034), we assessed whether perceptions of scientists' intellectual humility affect perceived trustworthiness of scientists and their research. In study 1, we found that seeing scientists as higher in intellectual humility was associated with greater perceived trustworthiness of scientists and support for science-based beliefs.

The conspiratorial mind: A meta-analytic review of motivational and personological correlates.

A tidal wave of research has tried to uncover the motivational and personological correlates of conspiratorial ideation, often studying these two classes of correlates in parallel. Here, we synthesize this vast and piecemeal literature through a multilevel meta-analytic review that spanned 170 studies, 257 samples, 52 variables, 1,429 effect sizes, and 158,473 participants. Overall, we found that the strongest correlates of conspiratorial ideation pertained to (a) perceiving danger and threat, (b) relying on intuition and having odd beliefs and experiences, and (c) being antagonistic and acting superior.

Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study.

Introduction: Early recognition and appropriate management of paediatric sepsis are known to improve outcomes. A previous system's biology investigation of the systemic immune response in neonates to sepsis identified immune and metabolic markers that showed high accuracy for detecting bacterial infection. Further gene expression markers have also been reported previously in the paediatric age group for discriminating sepsis from control cases.

Revisiting the rigidity-of-the-right hypothesis: A meta-analytic review.

The rigidity-of-the-right hypothesis (RRH), which posits that cognitive, motivational, and ideological rigidity resonate with political conservatism, is an influential but controversial psychological account of political ideology. Here, we leverage several methodological and theoretical sources of this controversy to conduct an extensive quantitative review with the dual aims of probing the RRH's basic assumptions and parsing the RRH literature's heterogeneity. Using multilevel meta-analyses of relations between varieties of rigidity and ideology measures alongside a bevy of potential moderators ( = 329, = 708, = 187,612), we find that associations between conservatism and rigidity are tremendously heterogeneous, suggesting a complex-yet conceptually fertile-network of relations between these constructs.

Clarifying the structure and nature of left-wing authoritarianism.

Authoritarianism has been the subject of scientific inquiry for nearly a century, yet the vast majority of authoritarianism research has focused on right-wing authoritarianism. In the present studies, we investigate the nature, structure, and nomological network of left-wing authoritarianism (LWA), a construct famously known as "the Loch Ness Monster" of political psychology. We iteratively construct a measure and data-driven conceptualization of LWA across six samples (N = 7,258) and conduct quantitative tests of LWA's relations with more than 60 authoritarianism-related variables.

Stepping Outside the Echo Chamber: Is Intellectual Humility Associated With Less Political Myside Bias?

In recent years, an upsurge of polarization has been a salient feature of political discourse in America. A small but growing body of research has examined the potential relevance of intellectual humility (IH) to political polarization. In the present investigation, we extend this work to political myside bias, testing the hypothesis that IH is associated with less bias in two community samples ( = 498; = 477).

Looking under the tinfoil hat: Clarifying the personological and psychopathological correlates of conspiracy beliefs.

Objective: We sought to replicate and extend provisional research on the personological correlates of conspiracy beliefs by examining their associations with abnormal- and normal-range personality domain-level traits and, for the first time, lower-order personality facets; we also examined internalizing symptoms.

Method: The study comprised four samples of community and student participants (N  = 1,927), and examined the cross-sectional relations between self-reported conspiratorial ideation and measures of (a) the six-factor model of general personality, (b) intellectual humility (IH), (c) traits relevant to certain personality disorder features (narcissism, psychopathy, disinhibition), and (d) internalizing symptoms (depression, anxiety, anger).

Results: Agreeableness and conscientiousness were significant, albeit modest, negative correlates of conspiracy beliefs, although other general personality dimensions tended to manifest negligible associations.

Personality Disorders as Emergent Interpersonal Syndromes: Psychopathic Personality as a Case Example.

Personality disorders have long been bedeviled by a host of conceptual and methodological quandaries. Starting from the assumption that personality disorders are inherently interpersonal conditions that reflect folk concepts of social impairment, the authors contend that a subset of personality disorders, rather than traditional syndromes, are (EISs): interpersonally malignant configurations (statistical interactions) of distinct personality dimensions that may be only modestly, weakly, or even negatively correlated. Preliminary support for this perspective derives from a surprising source, namely, largely forgotten research on the intercorrelations among the subscales of select MMPI/MMPI-2 clinical scales.

Psychopathy as an Emergent Interpersonal Syndrome: Further Reflections and Future Directions.

In our article (Lilienfeld et al., 2019), we hypothesized that psychopathy and some other personality disorders are emergent interpersonal syndromes (EISs): interpersonally malignant configurations of distinct personality subdimensions. We respond to three commentaries by distinguished scholars who raise provocative challenges to our arguments and intriguing suggestions for future research.

Do Psychopathic Traits Statistically Protect Against PTSD? A Retrospective Study of Vietnam Veterans.

Although psychopathy traits are traditionally associated with maladaptivity, certain traits may statistically buffer against risk for posttraumatic stress disorder (PTSD). Research suggests that psychopathy traits are differentially associated with PTSD, as boldness traits are negatively related to PTSD whereas disinhibition features are positively related. The authors sought to clarify the relations between psychopathy and PTSD in a large sample of Vietnam veterans ( = 2,598) and to examine the statistical interactions among (a) psychopathy traits and (b) combat exposure and psychopathy traits in predicting PTSD.

Sleep deprivation-induced pre- and postsynaptic modulation of orexin neurons.

Sleep/wake states are controlled by sleep- and wake-promoting systems, and transitions between states are thought to be regulated by their reciprocal inhibition and homeostatic sleep need. Orexin neurons are known to promote wake maintenance and stabilize the sleep/wake switch. Thus, we asked whether orexin neurons are modulated by homeostatic sleep need.

Potential effects of severe bilateral amygdala damage on psychopathic personality features: A case report.

The fearlessness model posits that psychopathy is underpinned by a deficiency in the capacity to experience fear, predisposing to other features of the condition, such as superficial charm, guiltlessness, callousness, narcissism, and dishonesty. Nevertheless, it is unclear whether fearlessness is irrelevant, necessary, sufficient, or merely contributory to psychopathy. In the present case study, we sought to examine the fearlessness model by studying an extensively investigated female patient-S.

Matrix-Based Activity Pattern Classification as a Novel Method for the Characterization of Enzyme Inhibitors Derived from High-Throughput Screening.

One of the central questions in the characterization of enzyme inhibitors is determining the mode of inhibition (MOI). Classically, this is done with a number of low-throughput methods in which inhibition models are fitted to the data. The ability to rapidly characterize the MOI for inhibitors arising from high-throughput screening in which hundreds to thousands of primary inhibitors may need to be characterized would greatly help in lead selection efforts.

Application of Titration-Based Screening for the Rapid Pilot Testing of High-Throughput Assays.

Pilot testing of an assay intended for high-throughput screening (HTS) with small compound sets is a necessary but often time-consuming step in the validation of an assay protocol. When the initial testing concentration is less than optimal, this can involve iterative testing at different concentrations to further evaluate the pilot outcome, which can be even more time-consuming. Quantitative HTS (qHTS) enables flexible and rapid collection of assay performance statistics, hits at different concentrations, and concentration-response curves in a single experiment.

Comparison of screening strategies to improve the diagnosis of latent tuberculosis infection in the HIV-positive population: a cohort study.

Background: HIV is the most important risk factor for progression of latent tuberculosis infection (LTBI) to active tuberculosis (TB). Detection and treatment of LTBI is necessary to reduce the increasing burden of TB in the UK, but a unified LTBI screening approach has not been adopted.

Objective: To compare the effectiveness of a TB risk-focused approach to LTBI screening in the HIV-positive population against current UK National Institute for Health and Clinical Excellence (NICE) guidance.

Retrospective occupational exposure assessment for case-control and case-series epidemiology studies based in Shanghai China.

To provide exposure information for epidemiology studies conducted in Shanghai from 2001 to 2008, we completed retrospective exposure assessments (EA) of benzene and other hazards. Interviewers administered questionnaires to subjects from Shanghai area hospitals. An initial exposure screening by EA staff members, blinded as to case-control status, stratified jobs into exposed, unexposed, or uncertain categories prior to review by a separate expert panel (EP).

A mechanistic study of the low pressure pyrolysis of linear siloxanes.

Matrix isolation IR spectroscopy has been used to study the vacuum pyrolysis of 1,1,3,3-tetramethyldisiloxane (L1), 1,1,3,3,5,5-hexamethyltrisiloxane (L2) and 3H,5H-octamethyltetrasiloxane (L3) at ca. 1000 K in a flow reactor at low pressures. The hydrocarbons CH3, CH4, C2H2, C2H4, and C2H6 were observed as prominent pyrolysis products in all three systems, and amongst the weaker features are bands arising from the methylsilanes Me2SiH2 (for L1 and L2) and Me3SiH (for L3).

Benzene exposure in industries using or manufacturing paint in China--a literature review, 1956-2005.

A systematic review of the Chinese literature was conducted from 1956 to 2005. The survey included both online and manual searching, as well as expert discussions aimed at providing insight into factors affecting benzene exposure levels in paint/coatings industries. Data extracted from 204 papers included: (1) year of occurrence, (2) type of paint/coatings products, (3) type of industries where the products were used or produced, (4) job titles and work activities, (5) type of literature searched, (6) working conditions whenever data were available, and (7) exposure levels.

Chronic sorrow in parents of children with type 1 diabetes.

Aim: This paper reports on a study exploring parents' longer-term experiences of having a child with type 1 diabetes.

Background: Parents of children with type 1 diabetes may experience a grief reaction at diagnosis similar to that normally associated with bereavement, but little is known about their long-term emotional adaptation. Chronic sorrow, a sustained but intermittent grief reaction, is identified in adults with diabetes but has not previously been explored in relation to parents.

A mechanistic study of cyclic siloxane pyrolyses at low pressures.

Matrix isolation IR spectroscopy has been used to study the vacuum pyrolysis of hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4) and decamethyl cyclopentasiloxane (D5), and the results interpreted in the context of various kinetic models. In particular, it is shown that the significant pyrolysis products--which include CH3, CH4, C2H2, C2H4, C2H6 and SiO--may be satisfactorily accounted for by radical reactions involving dimethylsiloxane (D1), and estimates are made of the various chain lengths for the proposed reactions based on a range of ambient conditions.

Equipment, exposure, emission review--specification of process equipment for worker exposure control.

Worker exposure to chemical agents may occur from equipment leaks in closed processes and from open system activities and maintenance (e.g., sampling, tank gauging, line breaking, equipment flushing, and drainage).

Independence for group practices: is it possible and desirable?

Technological advances, patient demands, pressures from payors, and change driven by hospitals or competing group practices combine to create a very dynamic practice management environment. For practice executives, these changes are focusing more attention on strategic and long-term planning, raising the question of continuing as independent private practices or considering other alternatives. There are several macro trends that impact the future of group practice.

Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.

The phosphorylation of IkappaB by the IKK complex targets it for degradation and releases NF-kappaB for translocation into the nucleus to initiate the inflammatory response, cell proliferation, or cell differentiation. The IKK complex is composed of the catalytic IKKalpha/beta kinases and a regulatory protein, NF-kappaB essential modulator (NEMO; IKKgamma). NEMO associates with the unphosphorylated IKK kinase C termini and activates the IKK complex's catalytic activity.