Survival and quality-of-life outcomes in early-stage NSCLC patients: a literature review of real-world evidence.

Aim: Assess the long-term survival and quality-of-life outcomes in early-stage NSCLC (eNSCLC) patients.

Methods: Review of long-term survival and quality-of-life after curative treatment in eNSCLC patients in observational studies.

Results: Disease-free proportion decreased in stage III vs stage I patients.

Treatment patterns and survival of patients with locoregional recurrence in early-stage NSCLC: a literature review of real-world evidence.

Approximately 10-50% of patients treated for early-stage (I-III), resectable non-small cell lung cancer (eNSCLC) will develop locoregional recurrence. There is a lack of prospective trials evaluating optimal post-surgery follow-up for this patient population, and treatment guidelines recommend salvage therapies such as surgery, local ablative therapy, and (chemo)radiotherapy. A literature review was conducted according to pre-defined criteria to identify observational studies describing treatment patterns and survival outcomes in patients with eNSCLC who experienced locoregional recurrence.

Arcuate NPY is involved in salt-induced hypertension via modulation of paraventricular vasopressin and brain-derived neurotrophic factor.

Chronic high salt intake is one of the leading causes of hypertension. Salt activates the release of the key neurotransmitters in the hypothalamus such as vasopressin to increase blood pressure, and neuropepetide Y (NPY) has been implicated in the modulation of vasopressin levels. NPY in the hypothalamic arcuate nucleus (Arc) is best known for its control in appetite and energy homeostasis, but it is unclear whether it is also involved in the development of salt-induced hypertension.

Surface water temperature impacts on coastal wetland denitrification: Implications for river reconnection.

Louisiana, located in the southeast United States, is home to 40% of the continental US's coastal wetlands yet accounts for 80% of the nation's coastal wetland loss. This loss is generally attributed to decreased sediment supply, hydrologic alteration from levees, channelization, subsidence, sea-level rise, and wave and tidal induced marsh edge erosion. The Mid-Barataria Sediment Diversion is a US $1.

Defining the Specific Pathogen-Free State of Using TaqMan Assays.

Colonies of valuable inbred and transgenic laboratory-reared frogs maintained for research constitute naïve populations of animals susceptible to some opportunistic infectious diseases. Therefore, it is prudent to characterize any new animal acquisitions before introduction into an existing colony as a biosecurity measure to preclude the concurrent introduction of an infectious microorganism associated with the new animal(s). In addition, some pathogens of , such as and spp, are zoonotic diseases, placing frog aquarists at risk for acquiring an infection.

Examining the impact of early longitudinal patient exposure on medical students' career choices.

Background: Medical schools include career direction experiences to help students make informed career decisions. Most experiences are short, precluding students from attaining adequate exposure to long-term encounters within medicine. We investigated the impact of the First Patient Program (FPP), which fosters longitudinal patient exposure by pairing junior medical students with chronically ill patients through their healthcare journey, in instilling career direction.

A time-resolved infrared vibrational spectroscopic study of the photo-dynamics of crystalline materials.

Time-resolved infrared vibrational spectroscopy is a structurally sensitive probe of the excited-state properties of matter. The technique has found many applications in the study of molecules in dilute solution phase but has rarely been applied to crystalline samples. We report on the use of a sensitive pump-probe time-resolved infrared spectrometer and sample handling techniques for studies of the ultrafast excited-state dynamics of crystalline materials.

Photocrystallographic structure determination of a new geometric isomer of [Ru(NH3)4(H2O)(eta1-OSO)][MeC6H4SO3]2.

The structure of a new metastable geometric isomer of [Ru(NH3)4(H2O)(SO2)][MeC6H4SO3]2 in which the SO2 group is coordinated through a single oxygen in an eta1-OSO bonding mode has been determined at 13 K; the new isomer was obtained as a 36% component of the structure within a single crystal upon irradiation using a tungsten lamp.

Three-dimensional object-oriented modeling of the stomach for the purpose of microprocessor-controlled functional stimulation.

Three-dimensional (3-D) object-oriented models are needed for optimizing gastric electrical stimulation by performing virtual computer experiments. The aim of the study was to create a 3-D object-oriented electromechanical model of the stomach in vivo for the purpose of microprocessor controlled functional stimulation. The stomach was modeled using coaxial truncated conoids as objects.

4,4'-Trimethylenedipyridinium bis[carboxymethylphosphonate(1-)]: a three-dimensional framework structure built from O-H...O, N-H...O and C-H...O hydrogen bonds.

In the title compound, C(13)H(16)N(2)(2+).2C(2)H(4)O(5)P(-), the cation lies across a twofold rotation axis in space group Fdd2. The anions are linked into molecular ladders by two O-H.

1,4,8,11-Tetraazoniacyclotetradecane tetrakis(phenylphosphonate) dihydrate forms hydrogen-bonded sheets.

In the title compound, C(10)H(28)N(4)(4+).4C(6)H(6)O(3)P(-).2H(2)O, the cation lies across a centre of inversion in space group P2(1)/n.

meso-5,5,7,12,12,14-Hexamethyl-4,11-diaza-1,8-diazoniacyclotetradecane (S)-malate(2-) methanol disolvate: a chain of rings generated by two pairs of N-H.O hydrogen bonds.

The title compound is a methanol-solvated salt, C(16)H(38)N(4)(2+).C(4)H(4)O(5)(2-).2CH(3)OH, in which the ionic components are linked into chains by two pairs of N-H.

meso-5,5,7,12,12,14-hexamethyl-1,4-diaza-8,11-diazoniacyclotetradecane bis(2-naphthoate) ethanol disolvate: centrosymmetric five-component aggregates linked into sheets by C-H...pi(arene) hydrogen bonding.

The title compound is an ethanol-solvated salt, C(16)H(38)N(4)(2+) x -2C(11)H(7)O(2)(-) x -2C(2)H(6)O, in which the cation lies across a centre of inversion in P2(1)/c. The ions are linked by N-H..

The 1:1 adduct of triphenylsilanol and 4,4'-bipyridyl, and three pairwise-concomitant triclinic polymorphs of the 4:1 adduct having Z' = 0.5, 1 and 4.

Crystallization from methanol solution of mixtures of triphenylsilanol and 4,4'-bipyridyl has given a 1:1 adduct (I), Ph(3)SiOH.C(10)H(8)N(2), and three polymorphic 4:1 adducts (II)-(IV), (Ph(3)SiOH)(4).C(10)H(8)N(2).

Phosphonopropionic acid as a building block in supramolecular chemistry: salts with organic diamines.

The structures of seven salts formed by phosphonopropionic acid with organic diamines are reported; in these salts, the hydrogen-bonded substructures formed by the anions can be zero-, one- or two-dimensional, while the overall hydrogen-bonded supramolecular structures are three-dimensional. The 1:1 adduct, compound (1), formed between 1,2-bis(4'-pyridyl)ethene and phosphonopropionic acid is a salt, [[(C(12)H(10)N(2))H(2)](2+)].[(C(12)H(10)N(2))].

Salts of maleic and fumaric acids with organic polyamines: comparison of isomeric acids as building blocks in supramolecular chemistry.

Maleic acid and fumaric acid both readily form adducts with organic diamines: maleic acid usually forms 2:1 adducts with bases, while fumaric acid usually forms 1:1 adducts, and the supramolecular structures within the two series are not simply related. The 1:2 adducts formed by 1,2-bis(4-pyridyl)ethane and by 4,4'-bipyridyl, respectively, with maleic acid, compounds (1) and (2), are salts [(diamine)H(2)(2+)].[(C(4)H(3)O(4))(-)](2) in which the cations lie across a centre of inversion and a twofold rotation axis, respectively.

Two polymorphs, with Z' = 1 and 2, of 2-amino-4-chloro-6-morpholinopyrimidine in P21/c, and 2-amino-4-chloro-6-piperidinopyrimidine, which is isomorphous and almost isostructural with the Z' = 2 polymorph.

Crystallization of 2-amino-4-chloro-6-morpholinopyrimidine, C(8)H(11)ClN(4)O, (I), yields two polymorphs, both with space group P2(1)/c, having Z' = 1 (from diethyl ether solution) and Z' = 2 (from dichloromethane solution), denoted (Ia) and (Ib), respectively. In polymorph (Ia), the molecules are linked by an N-H..

A triclinic polymorph of benzanilide: disordered molecules form hydrogen-bonded chains.

In the P-1 polymorph of benzanilide or N-phenylbenzamide, C(13)H(11)NO, the molecules are linked into simple C(4) chains by N-H...

Electrical activity from colon overlaps with normal gastric electrical activity in cutaneous recordings.

The stability of EGG recordings is affected by a variety of artifacts. The aim of this study was to investigate possible overlapping of dominant frequencies in recorded cutaneous electrical activity arising simultaneously from the stomach and/or colon. Ten normal volunteers, eight posttotal colectomy patients, and four patients posttotal gastrectomy were studied.

N,N'-Dithiobisphthalimide-nitrobenzene (2/1): a Pn solvate with localized solvent molecules ordered head-to-tail in channels.

N,N'-Dithiobisphthalimide crystallizes from nitrobenzene solution as a solvate, 2C(16)H(8)N(2)O(4)S(2).C(6)H(5)NO(2), having space group Pn. The bisphthalimide molecules are linked by C-H.

Self-assembled hydrogen-bonded bilayers in 1,4-diazabicyclo[2.2.2]octane-N-(phosphonomethyl)iminodiacetic acid-water (1/1/1.5).

The title compound is a hydrated salt, 1,4-diazoniabicyclo[2.2.2]octane-N-[(hydroxyphosphinato)methyl]iminiodiacetate-water (1/1/1.

Tetrameric triphenylsilanol, (Ph(3)SiOH)(4), and the adduct (Ph(3)SiOH)(2)-dimethyl sulfoxide, both at 120 K, and the adduct (Ph(3)SiOH)(4)-1,4-dioxan at 150 K: interplay of O[bond]H...O and C[bond]H...pi(arene) interactions.

The structure of tetrameric triphenylsilanol, C(18)H(16)OSi, (I), has been re-investigated at 120 (2) K. The hydroxyl H atoms were readily located and one of the arene rings is disordered over two closely positioned sets of sites. The molecules are linked into cyclic tetramers, having approximate 4 (S(4)) symmetry, via O[bond]H.

N,N'-Dithiobisphthalimide-1,4-dioxan (1/0.6): a C2/c solvate with disordered solvent molecules localized in channels.

N,N'-Dithiobisphthalimide crystallizes from 1,4-dioxan solution as a solvate, 3C(16)H(8)N(2)O(4)S(2) x 1.8C(4)H(8)O(2), having space group C2/c. Four of the 12 C(16)H(8)N(2)O(4)S(2) molecules in the unit cell lie on twofold rotation axes, while the other eight lie in general positions.

Microprocessor-controlled colonic peristalsis: dynamic parametric modeling in dogs.

The study aimed at completing a model of functional colonic electric stimulation and testing it for artificial recreation of peristalsis in dogs. Dynamic measurements of invoked single contractions obtained from two unconscious dogs as well as previously reported static contraction properties were utilized to suggest the optimal stimulation parameters of: (1) length of the stimulating electrodes, (2) separation between the successive electrode sets, (3) duration, and (4) phase lag between the stimuli sequentially applied to the electrode sets. The derived electrode configuration and stimulation pattern were adjusted for different anatomical dimensions and tested in distended colon full of viscous content.