HazBot: Development of a telemanipulator robot with haptics for emergency response.

Objectives: To design a remotely operated robot, "HazBot," for bioevent disaster response; specifically, to improve existing commercial robots' capabilities in handling fixed-facility hazmat incidents via a unique robot controller that allows the human operator to easily manipulate HazBot in disaster situations.

Design: The HazBot's design objectives were for a robot to approach a building, open doors, enter, and navigate the building. The robot's controlling device was designed to provide features not available in current robots: dexterous manipulation and enhanced sensory (touch) feedback via "haptic" technology.

The prelamin A pre-peptide induces cardiac and skeletal myoblast differentiation.

Prelamin A processing is unique amongst mammalian proteins and results in the production of a farnesylated and carboxymethylated peptide. We examined the effect of pathogenic LMNA mutations on prelamin A processing, and of the covalently modified peptide on cardiac and skeletal myoblast differentiation. Here we report a mutation associated with dilated cardiomyopathy prevents prelamin A peptide production.

Who will care for Iraq's wounded warriors? Health policy and national security.

Introduction: Since 2003, Iraq has struggled to build a single national health system administered by the Iraqi Ministry of Health, but politics, lack of leadership, and a cultural bias against treating soldiers in civilian hospitals have hindered access to care for members of Iraq's armed forces who are wounded in combat.

Methods: U.S.

Microvascular anastomoses performed in rats using a microsurgical telemanipulator.

Objective: To determine the feasibility of performing microsurgical procedures with a remote telemanipulator using a rat femoral artery anastomosis model.

Materials And Methods: A remote telemanipulator system was developed that enabled precision movements to be performed at up to 30x magnification. Ten 1-mm femoral artery anastomoses were performed in rats using the telemanipulator, and results were compared to those from a control group in which the procedure was performed with conventional microsurgical techniques.

Quantitative evaluation of surgical task performance by remote-access endoscopic telemanipulation.

Background: The performance limitations inherent in minimally invasive surgery may be overcome by using an interface that provides intuitive orientation for video display and tool manipulation. A prototype remote-access endoscopic telemanipulator was designed to fulfill these requirements and used for a surgical anastomosis task.

Methods: A remote-access telemanipulator system, employing remote center-of-motion geometry, was used to complete distant in vitro tubular anastomoses.

Human phosphoribosylformylglycineamide amidotransferase (FGARAT): regional mapping, complete coding sequence, isolation of a functional genomic clone, and DNA sequence analysis.

Purines play essential roles in many cellular functions, including DNA replication, transcription, intra- and extra-cellular signaling, energy metabolism, and as coenzymes for many biochemical reactions. The de-novo synthesis of purines requires 10 enzymatic steps for the production of inosine monophosphate (IMP). Defects in purine metabolism are associated with human diseases.

Remote operative urology using a surgical telemanipulator system: preliminary observations.

Objectives: A prototype surgical telemanipulator system was evaluated to determine the feasibility of remotely performing operative urology.

Methods: Surgeons operated remotely on anesthetized swine (n = 4), using a four degree-of-freedom teleoperator system. A stereoscopic video display of the remote surgical field guided tissue manipulation, which was performed using standard instrument tips attached to robotic arms.

Use of an intuitive telemanipulator system for remote trauma surgery: an experimental study.

Background: Death from battlefield trauma occurs rapidly. Potentially salvageable casualties generally exsanguinate from truncal hemorrhage before operative intervention is possible. An intuitive telemanipulator system that would allow distant surgeons to remotely treat injured patients could improve the outcome from severe injuries.

Vascular applications of telepresence surgery: initial feasibility studies in swine.

Purpose: Telepresence surgery is a novel technology that will allow procedures to be performed on a patient at locations that are physically remote from the operating surgeon. This new method provides the sensory illusion that the surgeon's hands are in direct contact with the patient. We studied the feasibility of the use of telepresence surgery to perform basic operations in vascular surgery, including tissue dissection, vessel manipulation, and suturing.

Complex task performance in Cyberspace. Surgical procedures in a telepresence environment.

To assess the capabilities of our fully functional, prototype telepresence surgery system, experienced surgeons performed complete operative procedures on live, anesthetized pigs. Cholecystectomy, the prototypical procedure for evaluating the integration of surgical skills, was successfully performed in six animals. There were no aborted attempts or complications.