Polymeric pH-Responsive Metal-Supramolecular Nanoparticles for Synergistic Chemo-Photothermal Therapy.

Stimuli-responsive drug delivery carriers, particularly those exhibiting pH sensitivity, have attracted significant scholarly interest due to their promising potential in anticancer therapeutic applications. This phenomenon can primarily be ascribed to the inherently acidic nature of tumor microenvironments. However, pH-responsive carriers frequently require the incorporation of functional groups or materials sensitive to pH changes.

Enhancing Prediction of Myocardial Recovery After Coronary Revascularization: Integrating Radiomics from Myocardial Contrast Echocardiography with Machine Learning.

Introduction: Chronic coronary artery disease (CAD) management often relies on myocardial contrast echocardiography (MCE), yet its effectiveness is limited by subjective interpretations and difficulty in distinguishing hibernating from necrotic myocardium. This study explores the integration of machine learning (ML) with radiomics to predict functional recovery in dyskinetic myocardial segments in CAD patients undergoing revascularization, aiming to overcome these limitations.

Methods: This prospective study enrolled 55 chronic CAD patients, dividing into training (39 patients, 205 segments) and testing sets (16 patients, 68 segments).

Modeling of a second harmonic spectrum in passive phase demodulation.

Spectral compression by passive phase demodulation provides an effective way to obtain a high-power single-frequency second harmonic (SH) laser. In this method, a single-frequency laser is broadened by (0, ) binary phase modulation for stimulated Brillouin scattering suppression in a high-power fiber amplifier and compressed to single frequency after frequency doubling. The effectiveness of compressing is determined by the properties of the phase modulation system, including the modulation depth, frequency response of modulation system, and modulation signal noise.

Nomogram for predicting skip metastasis in cN0 papillary thyroid cancer patients at increased risk of lymph node metastasis.

Background: Skip lymph node metastasis (SLNM) refers to lateral lymph node metastasis (LLNM) without involving central lymph node (CLN). Some microscopic nodal positivity may be difficult to detect before surgery due to atypical imaging characteristics. These patients are misdiagnosed as having clinically node-negative (cN0) papillary thyroid cancer (PTC) even after central lymph node dissection, leading to a high risk of developing LNM after surgery.

The Pandora Effect: The Power and Peril of Curiosity.

Curiosity-the desire for information-underlies many human activities, from reading celebrity gossip to developing nuclear science. Curiosity is well recognized as a human blessing. Is it also a human curse? Tales about such things as Pandora's box suggest that it is, but scientific evidence is lacking.

Approach aversion: negative hedonic reactions toward approaching stimuli.

We live in a dynamic world, surrounded by moving stimuli-moving people, moving objects, and moving events. The current research proposes and finds an approach aversion effect-individuals feel less positively (or more negatively) about a stimulus if they perceive it to be approaching rather than receding or static. The effect appears general, occurring whether the stimulus is initially negative or nonnegative and whether it moves in space (toward or away from "here"), in time (toward or away from "now"), or in probability (toward or away from "sure").