Impact of hypertension on liver fibrosis in patients with metabolic dysfunction-associated fatty liver disease.

Background: This study aims to evaluate the association between hypertension and the risk of fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD) patients, as well as to investigate the impact of hypertension on the progression of liver fibrosis within this population.

Methods: We utilized data from the NHANES 2017 to March 2020. Multivariate logistic regression models were employed to control for sociodemographic and metabolic factors to determine the associations between hypertension, MASLD, and fibrosis.

Bidirectional relationship between afternoon naps and depressive symptoms in Chinese middle-aged and older adults: Evidence from a nationally representative cohort study.

Background: Limited studies have investigated the association between depressive symptoms and napping habits. In this study, nationally representative data from the China Health and Retirement Longitudinal Study (CHARLS) were employed to conduct cross-sectional and longitudinal analyses to investigate their associations among Chinese middle-aged and older adults.

Methods: The study included 12,208 participants from the 2015 CHARLS.

Quickly Calculating the Activity Coefficient of a NaCl Solution Based on Machine Learning Algorithms.

The activity coefficient represents the deviation between an actual solution and an ideal solution, influencing the solubility and diffusion of CO within a saltwater layer. Consequently, it serves as a crucial parameter for numerical simulations of CO storage in deep saltwater layers. However, in numerical simulations of CO geological storage, the majority of studies rely on the Helgeson-Kirkham-Flowers (HKF) equation to compute activity coefficients, which necessitates obtaining Debye-Hückel (DH) parameters.

Achieving automated and high-precision in situ analysis of the dimensional accuracy and dynamic deformation of 3D-printed surgical templates: an in vitro study.

Purpose: To demonstrate the viability of a coordinate-measuring machine (CMM) for the geometric analysis of 3D printed surgical templates.

Methods: The template was designed and modified by adding 18 cylindrical landmarks for CMM test and then classified into five groups according to the slicing software and resins (opaque and transparent): Streamflow-O, Streamflow-T, Shapeware-T, Rayware-T and Polydevs-T (N = 3). Three standing times (0 w, 1 w, and 2 w) were included to observe possible deformation.

A mixed Ce/Eu metal-organic framework for ratiometric detection of Al ion.

As a heavy metal ion, excessive aluminum ions pose a serious threat to human health and the ecological environment. Developing a simple, efficient, and fast detection method to detect the content of aluminum ions is of great significance, especially for ensuring human health and ecological safety. Herein, the mixed rare earth metal-organic framework (CeEuTPTC and CeEuTPTC) were prepared based on simple ligand 1,1':4',1″-Terphenyl-2',4,4″,5'-tetracarboxylic acid (HTPTC).

The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy.

Acute kidney injury (AKI) is a significant issue in public health, displaying a high occurrence rate and mortality rate. Ferroptosis, a form of programmed cell death (PCD), is characterized by iron accumulation and intensified lipid peroxidation. Recent studies have demonstrated the pivotal significance of ferroptosis in AKI caused by diverse stimuli, including ischemia-reperfusion injury (IRI), sepsis and toxins.

Mesoporous silica thin film as effective coating for enhancing osteogenesis through selective protein adsorption and blood clotting.

The role of blood clots in tissue repair has been identified for a long time; however, its participation in the integration between implants and host tissues has attracted attention only in recent years. In this work, a mesoporous silica thin film (MSTF) with either vertical or parallel orientation was deposited on titania nanotubes surface, resulting in superhydrophilic nanoporous surfaces. A proteomic analysis of blood plasma adsorption revealed that the MSTF coating could significantly increase the abundance of acidic proteins and the adsorption of coagulation factors (XII and XI), with the help of cations (Na, Ca) binding.

Diagnosis and treatment of secondary nephrotic syndrome with rash as the first symptom: a case report.

Background: Membranous nephropathy (MN) is a common type of nephrotic syndrome (NS) in adults, accounting for about 20-30% of cases. Although secondary to specific factors, the coexistence of MN and mantle cell lymphoma (MCL) has been scarcely reported in clinical literature.

Case Presentation: A 59-year-old Chinese male was admitted to the hospital with a generalized pruritic rash with bilateral lower extremity edema, which did not improve significantly after symptomatic treatment.

Constructing heterogeneous interface between CoO and RuO with enhanced electronic regulation for efficient oxygen evolution reaction at large current density.

Exploring effective strategies for developing new high-efficiency catalysts for water splitting is essential for advancing hydrogen energy technology. Herein, CoO/RuO heterojunction interface is construct through ion exchange reaction and pyrolysis. The as-synthesized CoO/RuO-4 exhibits outstanding oxygen evolution reaction (OER) activity at the current density of 100 mA cm with a low overpotential of 276 mV, and remarkable stability (maintaining activity for 60 h at 100 mA cm).

Did the popularization of the Internet impact Chinese citizens' attitude towards foreign countries? An empirical study based on two surveys.

Citizens' attitudes towards foreign countries are considered an important factor in making foreign policy. This also holds in China, where public opinion is given significant weight in foreign policy-making. On the other hand, the media serves as a gateway for citizens to access the outside world, shaping their attitudes towards foreign countries.

Bioavailability of Coix Seed Polyphenols in a MKN28/Caco-2 Continuous Transport Model and Their Lipid-Lowering Effects via Modulating Adipocyte Differentiation of 3T3-L1 Cells.

At present, most of the research on coix seed polyphenols (CSPs) focuses on the separation, purification, structure analysis, and biological functions of specific components, and few studies have considered the overall bioavailability and the metabolites that play a role after digestion and absorption and their biological functional activities. In this study, we constructed a MKN28 and Caco-2 cell monolayer continuous transport model (MCTM) to study the bioavailability of CSPs in the digestion and absorption stages of the stomach and small intestine. Using this model, we innovatively divided CSPs into easy-to-digest and hard-to-digest polyphenols and studied their intracellular lipid-lowering function and their influence on human intestinal flora.

Improvement of gut microbiome and intestinal permeability following splenectomy plus pericardial devascularization in hepatitis B virus-related cirrhotic portal hypertension.

The gut microbiome is an essential component of the intestinal mucosal barrier, critical in regulating intestinal permeability. Microbiome dysbiosis and intestinal permeability changes are commonly encountered conditions in patients with cirrhosis and are closely related to its development and further complications. However, alterations in the gut microbiome and intestinal permeability in chronic hepatitis B virus (HBV) patients with cirrhotic portal hypertension after undergoing a splenectomy plus pericardial devascularization (SPD) have not been investigated.

Screening and identification of high bioavailable oligopeptides from rapeseed napin (Brassica napus) protein-derived hydrolysates via Caco-2/HepG2 co-culture model.

Rapeseed napin (Brassica napus) protein-derived hydrolysates (RNPHs, 1-4) are mixtures of peptides, prior to reaching liver tissue and playing their antidiabetic role, at least being absorbed and metabolized by the intestinal barrier. The study aims at screening and identifying high bioavailable rapessed napin-derived oligopeptides via simulated gastrointestinal digestion and absorption. Specifically, RNPHs were obtained using a novel ultrasound-assisted digestive device.

High-dose vitamin C ameliorates cardiac injury in COVID-19 pandemic: a retrospective cohort study.

Background: Cardiac injury is common and associated with poor clinical outcomes in COVID-19. Data are lacking whether high-dose intravenous vitamin C (HIVC) could help to ameliorate myocardial injury in the pandemic.

Methods: The retrospective cohort study included consecutive severe and critically ill COVID-19 patients with cardiac injury receiving symptomatic supportive treatments alone or together with HIVC.

Water-Robust Zinc-Organic Framework with Mixed Nodes and Its Handy Mixed-Matrix Membrane for Highly Effective Luminescent Detection of Fe, CrO, and CrO in Aqueous Solution.

Metal-organic frameworks (MOFs) and MOF-based composites as luminescent sensors with excellent economic practicability and handy operability have attracted much attention. Herein, we designed and fabricated a porous Zn-based MOF, [Zn(OBA)(L)·2DMA] [; HOBA = 4,4'-oxybis(benzoic acid), L = 2,4,6-tris(4-pyridyl)pyridine, and DMA = ,-dimethylacetamide], with mixed nodes under solvothermal conditions, and the pore size of 5.9 Å was calculated from N adsorption isotherms by using a density functional theory model.

A Trinuclear Cobalt-Organic Framework: Solvatochromic Sensor towards CH Cl , and its Derivative as an Anode of Lithium-Ion Batteries with High Performance.

Here, a porous cobalt-organic framework with pillared layer structures, namely [Co OBA PTD(H O) ⋅ 2 DMA⋅H O] (1, H OBA=4,4'-oxybis(benzoic acid); PTD=6-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine), was fabricated by using cobalt trinuclear nodes, low-cost carboxylic linker, and accessible nitrogen heterocyclic ligands. This compound exhibited a highly efficient solvatochromism towards CH Cl within one minute and can be used 200 times at least. The corresponding dropper detector was assembled as a practical sensor.

Tetranuclear cobalt(ii)-isonicotinic acid frameworks: selective CO capture, magnetic properties, and derived "CoO" exhibiting high performance in lithium ion batteries.

Two new 3D cobalt metal-organic frameworks (MOFs), [Co4(CH3COO)(in)5(μ3-OH)2]·2H2O (1) and [Co4(SO4)2(in)4(DMF)2]·3DMF (2) (Hin = isonicotinic acid), have been prepared through the anion template method. Compound 1 consists of rare odd-number connected (9-connected) cubane-like SBUs, while compound 2 consists of 8-connected high-symmetry square-planar clusters. Magnetic studies indicate that compound 1 exhibits spin-canting antiferromagnetic ordering, while compound 2 shows antiferromagnetic behavior.

A Nano-Sized [Mn ] Metallamacrocycle as a Building Unit to Construct Stable Metal-Organic Frameworks: Effective Gas Adsorption and Magnetic Properties.

A stable hex-type metal-organic framework (MOF, WMOF-1) was constructed by nano-sized [Mn ] metallamacrocycle secondary building unit, being the one with the highest nuclearity of manganese wheel-like node in the microporous MOF. WMOF-1 displays an effective gas adsorption and the antiferromagnetic behavior.

Mechanistic insights into N-Bromosuccinimide-promoted synthesis of imidazo[1,2-a]pyridine in water: Reactivity mediated by substrates and solvent.

The mechanism of N-Bromosuccinimide (NBS) promoted synthesis of imidazo[1,2-a]pyridine in water as well as the effective activation modes of NBS was investigated by Density Functional Theory (DFT) calculations. Two main mechanisms that differ in the reaction sequence of substrate were explored: styrene with NBS then followed by 2-aminopyridine (M1) or simultaneously with NBS and 2-aminopyridine (M2), and water-assisted M2 is the more favored one. We found that the adding sequence of 2-aminopyridine affects profoundly on the title reaction.

Effects of the Screw-Access Hole Diameter on the Biomechanical Behaviors of 4 Types of Cement-Retained Implant Prosthodontic Systems and Their Surrounding Cortical Bones: A 3D Finite Element Analysis.

Purpose: To investigate the effect(s) of screw-access hole (SAH) in different diameters on the cement-retained implant prosthodontic systems and surrounding cortical bones.

Materials And Methods: Twenty finite element models were divided into 4 groups: 2 types of full-contour (FC) crowns (Y-TZP, gold alloy) and 2 types of porcelain-fused-to-metal crowns (based on Co-Cr, Au-Pd alloy). For each group, 5 crowns were simulated by varying the diameter of SAH (0, 1, 2, 3, and 4 mm).

Selective chiral symmetry breaking and luminescence sensing of a Zn(ii) metal-organic framework.

The chiral Zn(ii) metal-organic framework [(CH3)2NH2]5[Zn1.5(Zn3O)(TATAT)2]·9DMF·17H2O (1) has been prepared from achiral precursors Zn(NO3)2·6H2O and 5,5',5''-(1,3,5-triazine-2,4,6-triyl)tris(azanediyl)triisophthalate (H6TATAT) in a solvent mixture of DMF/MeOH/H2O/HCOOH without any chiral sources. In particular, the non-random handedness excess (1P ≫ 1M) was generated and was verified by single-crystal X-ray diffraction and solid-state circular dichroism spectroscopy.

A Weighted Combination Method for Conflicting Evidence in Multi-Sensor Data Fusion.

Dempster⁻Shafer evidence theory is widely applied in various fields related to information fusion. However, how to avoid the counter-intuitive results is an open issue when combining highly conflicting pieces of evidence. In order to handle such a problem, a weighted combination method for conflicting pieces of evidence in multi-sensor data fusion is proposed by considering both the interplay between the pieces of evidence and the impacts of the pieces of evidence themselves.

3D Pd/Co core-shell nanoneedle arrays as a high-performance cathode catalyst layer for AAEMFCs.

A novel cathode architecture using vertically aligned Co nanoneedle arrays as an ordered support for application in alkaline anion-exchange membrane fuel cells (AAEMFCs) has been developed. The Co nanoneedle arrays were directly grown on a stainless steel sheet a hydrothermal reaction and then a Pd layer was deposited on the surface of the Co nanoneedle arrays using a vacuum sputter-deposition method to form Pd/Co nanoneedle arrays. After transferring the Pd/Co nanoneedle arrays to an AAEM, a cathode catalyst layer was formed.

A novel IrNi@PdIr/C core-shell electrocatalyst with enhanced activity and durability for the hydrogen oxidation reaction in alkaline anion exchange membrane fuel cells.

Herein, a novel non-platinum core-shell catalyst, namely, IrNi@PdIr/C was prepared via a galvanic replacement reaction; it exhibits enhanced hydrogen oxidation activity and excellent stability under alkaline conditions. Electrochemical experiments demonstrated that the mass and specific activities at 50 mV of IrNi@PdIr/C are 2.1 and 2.

Diverse Structures Based on a Heptanuclear Cobalt Cluster with 0D to 3D Metal-Organic Frameworks: Magnetism and Application in Batteries.

Polymetallic complexes with interesting multifunctions have attracted extensive investigation. Synthesized through the use of different cobalt salt anions and solvents, five complexes, namely [Co Co (H L) Cl (MeOH)] (1), [Co Co (H L) (CH COO) (HCOO)⋅H O] (2), [Co Co (H L) (HCOO) (NO )⋅2H O] (3), [Co Co (H L) (bda)(CH COO) ⋅2H O] (4), and [Co Co (H L) (ipa)(HCOO) (dmf)⋅H O] (5) (H L=bis-tris propane; BDA=biphenyl-4,4'-dicarboxylic acid; IPA=isophthalic acid; DMF=N,N-dimethylformamide), based on the heptanuclear {Co Co } cluster with structures from 0D to 3D metal-organic frameworks (MOFs) have been solvothermally synthesized. Compound 1 is the first 0D heptanuclear cluster based on H L.