Publications by authors named "Bowen Lin"

Clarifying the inceptive pathophysiology of hypertensive heart disease helps to impede the disease progression. Through coarctation of the infrarenal abdominal aorta (AA), we induced hypertension in minipigs and evaluated physiological reactions and morpho-functional changes of the heart. Moderate aortic coarctation was achieved with approximately 30 mmHg systolic pressure gradient in minipigs.

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This multicenter study explored the survival benefits of upfront primary tumor resection (PTR) followed by first-line cetuximab plus chemotherapy in real-world patients with wild-type metastatic colorectal cancer (mCRC). Treatment options for mCRC include chemotherapy, targeted therapy, immunotherapy, and surgery. The efficacy of upfront PTR in managing mCRC remains unclear.

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Introduction: Cell fate determination and transition are of paramount importance in biology and medicine. Naive pluripotency could be achieved by reprogramming differentiated cells. However, the mechanism is less clear.

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Sorption-based atmospheric water harvesting (SAWH) is a promising approach for supplying water in off-grid arid regions. However, it is difficult to improve the SAWH efficiency because water undergoes multiple phase transformations, such as water vapor-water (desorption and condensation) in the desorption phase. To address this issue, an ultrahygroscopic temperature-responsive hydrogel nanofiber inspired by Tillandsia is developed, comprising poly N-isopropylacrylamide, poly N-dimethylacetamide, and carbon nanotubes and impregnated with lithium chloride (PCP@LiCl).

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  • The study focuses on the SALL2 gene, part of the spalt gene family, and its critical role in mouse embryo development, particularly in the nervous system.
  • * Researchers found that SALL2 is essential for neural differentiation, as Sall2 knockout embryonic stem cells showed impaired ability to become neural stem cells and create neural tube organoids.
  • * Utilizing ChIP-seq, the study identified Tuba1a as a key target gene influenced by SALL2, highlighting its importance in understanding potential human nervous system disorders linked to SALL2 mutations.
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Cancer research is continuously exploring new avenues to improve treatments, and ferroptosis induction has emerged as a promising approach. However, the lack of comprehensive analysis of the ferroptosis sensitivity in different cancer types has limited its clinical application. Moreover, identifying the key regulator that influences the ferroptosis sensitivity during cancer progression remains a major challenge.

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Cardiac biological pacing (BP) is one of the future directions for bradyarrhythmias intervention. Currently, cardiac pacemaker cells (PCs) used for cardiac BP are mainly derived from pluripotent stem cells (PSCs). However, the production of high-quality cardiac PCs from PSCs remains a challenge.

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Background: Proton therapy is preferred for its dose conformality to spare normal tissues and organs-at-risk (OAR) via Bragg peaks with negligible exit dose. However, proton dose conformality can be further optimized: (1) the spot placement is based on the structured (e.g.

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Background: While minimizing plan delivery time is beneficial for proton therapy in terms of motion management, patient comfort, and treatment throughput, it often poses a tradeoff with optimizing plan quality. A key component of plan delivery time is the energy switching time, which is approximately proportional to the number of energy layers, that is, the cardinality.

Purpose: This work aims to develop a novel optimization method that can efficiently compute the pareto surface between plan quality and energy layer cardinality, for the planner to navigate through this quality-and-efficiency tradeoff and select the appropriate plan of a balanced tradeoff.

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Hypoxia-induced cardiomyocyte apoptosis is one major pathological change of acute myocardial infarction (AMI), but the underlying mechanism remains unexplored. CDC-like kinase 3 (CLK3) plays crucial roles in cell proliferation, migration and invasion, and nucleotide metabolism, however, the role of CLK3 in AMI, especially hypoxia-induced apoptosis, is largely unknown. The expression of CLK3 was elevated in mouse myocardial infarction (MI) models and neonatal rat ventricular myocytes (NRVMs) under hypoxia.

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  • Transcription factors HAND1 and HAND2 are crucial for heart development, and their abnormal expression can lead to serious heart defects, but their exact roles in early heart cell formation are not well understood.
  • Researchers created human embryonic stem cell lines with knocked out HAND1 and HAND2 to study how these factors affect cardiomyocyte differentiation, employing techniques like flow cytometry and RNA sequencing to track changes.
  • Results showed that knocking out both HAND1 and HAND2 delayed heart cell differentiation, affected the development of specific heart cell types, and altered the electrical characteristics of the resulting cardiomyocytes.
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Cancer cells can evade immune elimination by activating immunosuppressive signaling pathways in the tumor microenvironment (TME). Targeting immunosuppressive signaling pathways to promote antitumor immunity has become an attractive strategy for cancer therapy. Aurora-A is a well-known oncoprotein that plays a critical role in tumor progression, and its inhibition is considered a promising strategy for treating cancers.

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  • A multicenter study assessed the survival benefits of combining metastasectomy with first-line cetuximab-based chemotherapy in patients with wild-type metastatic colorectal cancer (mCRC), measuring overall survival (OS) and progression-free survival (PFS) as primary endpoints.
  • Of the 758 enrolled patients, the study found that those who underwent metastasectomy had significantly better OS (54.9 months) and PFS (21.0 months) compared to those who did not, highlighting the importance of this surgical intervention in treatment outcomes.
  • The analysis also identified that patients receiving 14 or more treatment cycles had improved survival rates and higher chances of undergoing metastasectomy, suggesting this as an optimal treatment duration for maximizing outcomes in m
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  • * Developing Arctic shipping routes could enhance trade efficiency and reduce reliance on congested routes, despite the harsh conditions these routes present.
  • * The paper reviews various challenges of Arctic navigation, including extreme weather, ice hazards, and lack of infrastructure, providing insights for researchers and policymakers.
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Multigene mutations in colorectal cancer (CRC), including KRAS, BRAF, and p53, afford high metastatic ability and resistance to EGFR-targeting therapy. Understanding the molecular mechanisms regulating anti-EGFR-resistant CRC metastasis can improve CRC therapy. This study aimed to investigate the effects of IL-8 and the activation of KRAS on reactive oxygen species (ROS) production and metastasis of hyperlipidemia-associated CRC harboring mutations of KRAS and p53.

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  • Malnutrition is a frequent issue in patients with metastatic colorectal cancer (mCRC) undergoing targeted therapy and chemotherapy, leading to increased toxicity and lower survival rates.
  • This study analyzed data from 758 patients treated with cetuximab and chemotherapy, separating them into groups that did or did not receive supplemental home parenteral nutrition (HPN).
  • Results showed that the HPN group had higher rates of successful surgeries, longer treatment durations, and improved overall and progression-free survival compared to the non-HPN group, suggesting HPN may enhance treatment outcomes for certain mCRC patients.
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Aims: We sought to investigate the relationship between circulating tissue plasminogen activator (t-PA) level and long-term outcomes in stable coronary artery disease patients with or without aortic valve sclerosis (AVSc).

Methods And Results: Serum levels of t-PA were determined in 347 consecutive stable angina patients with (n = 183) or without (n = 164) AVSc. Outcomes were prospectively recorded as planned clinic evaluations every 6 months up to 7 years.

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Y-box binding protein 1 (YBX1) has been reported to be involved in the transcriptional regulation of various pathophysiological processes, such as inflammation, oxidative stress, and epithelial-mesenchymal transformation. However, its precise role and mechanism in regulating hepatic fibrosis remain unclear. In this study, we aimed to investigate the effects of YBX1 on liver fibrosis and its potential mechanism.

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  • Metastasis, the spread of cancer to other parts of the body, is a key factor in the high mortality rates of colorectal cancer, with nuclear TYRO3 receptor identified as a major predictor of poor patient outcomes.
  • The study reveals that the kinase activity of nuclear TYRO3 and its effect on matrix metalloproteinase-2 (MMP-2) are crucial for promoting metastasis, while emphasizing that this process does not require a ligand to function.
  • Researchers found that the interaction between TYRO3, MMP-2, and bromodomain-containing protein 3 (BRD3) can lead to drug resistance and enhanced metastasis, suggesting that targeting this pathway could help improve treatment outcomes for colorectal cancer
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  • The study investigates endometriosis (EMs), a common gynecological condition with rising incidence, characterized by symptoms like chronic pain and infertility, but with unclear causes.
  • Researchers analyzed both gene expression and DNA methylation profiles from endometrial tissues of ovarian EM patients, identifying significant differences in methylation and gene expression.
  • The findings highlight the role of DNA methylation in regulating gene expression, offering new insights into the molecular mechanisms of endometriosis, with several candidate genes identified for further research.
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Sprouty2 (SPRY2) is known to inhibit the RAS/MAPK/ERK pathway, and is a potential study target for cancer. The effect of SPRY2 in colorectal cancer (CRC) and whether it is influenced by KRAS mutation are not known. We manipulated SPRY2 gene expression and used an activating KRAS-mutant plasmid to determine its effect on CRC cell function in vitro and/or in vivo.

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  • The ventricular chamber's development relies on precise interactions among different cell types, significantly influenced by alternative splicing.
  • The study identifies PTBP1, an alternative splicing factor, as crucial for proper ventricular morphogenesis, particularly in endothelial cells, while being minimal in cardiomyocytes.
  • Deleting PTBP1 in endothelial cells disrupts their migration, negatively impacting cardiomyocyte growth and resulting in left ventricular noncompaction (LVNC), highlighting its role in the development of congenital heart diseases.
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Aim: The OPTIM1SE study observed long-term real-world outcomes of cetuximab-based infusional 5-fluorouracil (5-FU) regimens for first-line treatment of metastatic colorectal cancer (mCRC) across Asia-Pacific and Middle East regions, aiming to characterize their use, effectiveness, and safety in routine practice.

Methods: OPTIM1SE was a prospective, open-label, observational study. Patients with untreated KRAS wild-type mCRC and distant metastases were treated per locally approved labels and monitored for 3 years via electronic medical records.

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Objective: To investigate the effect of femoral component valgus/varus angle (FCVA) on the mid-term outcome after unicondylar knee arthroplasty.

Methods: Patients who underwent unicompartmental knee replacement in the Department of Bone and Joint Surgery, were retrospectively analyzed. According to the postoperative femoral prosthesis internal and external rotation angle, patients were divided into six groups the postoperative femoral prosthesis internal and external rotation angle: standard group, mildly abnormal group.

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Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion (I/R) injury. However, a genome-wide map of histone modifications and the underlying epigenetic signatures in myocardial I/R injury have not been established. Here, we integrated transcriptome and epigenome of histone modifications to characterize epigenetic signatures after I/R injury.

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