AR regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration.

Background: Reduction of inflammatory damage and inhibition of nucleus pulposus (NP) apoptosis are considered to be the main effective therapy idea to reverse the intervertebral disc degeneration (IDD) and alleviate the chronic low back pain. The adenosine A2A receptor (A2AR), as a member of G protein-coupled receptor families, plays an important role in the anti-inflammation and relieving pain. So far, the impact of A2AR on IDD therapy is unclear.

Efficacy of PE-PLIF with a novel ULBD approach for lumbar degeneration diseases: a large-channel endoscopic retrospective study.

Purpose: This study aims to assess the effectiveness of Percutaneous Endoscopic Posterior Lumbar Interbody Fusion (PE-PLIF) combined with a novel Unilateral Laminotomy for Bilateral Decompression (ULBD) approach using a large-channel endoscope in treating Lumbar Degenerative Diseases (LDD).

Methods: This retrospective analysis evaluates 41 LDD patients treated with PE-PLIF and ULBD from January 2021 to June 2023. A novel ULBD approach, called 'Non-touch Over-Top' technique, was utilized in this study.

3D orientation and kinematic characteristics of zygapophyseal joints while sitting.

Background: Orientation of the lumbar facet joints (FJs) in the transverse plane is associated with degenerative lumbar spine disease. However, there is a lack of measurements of the sagittal and coronal facet angles, and the effect of 3D facet angles on joint motion in the sitting position is unknown. The present study was to investigate the 3D orientation and motion characteristics of the FJ in the sitting position.

Investigation of geometric deformations of the lumbar disc during axial body rotations.

Background: Quantitative data on in vivo vertebral disc deformations are critical for enhancing our understanding of spinal pathology and improving the design of surgical materials. This study investigated in vivo lumbar intervertebral disc deformations during axial rotations under different load-bearing conditions.

Methods: Twelve healthy subjects (7 males and 5 females) between the ages of 25 and 39 were recruited.

The effect of various weight-bearing activities on the motion of lumbar facet joints in vivo.

Background: Lumbar facet joints (LFJs) are usually related to the pathogenesis of the spine. The purpose of this paper is to study the effects of lifting load on the motion of lower lumbar facet joints in vivo.

Methods: Ten healthy volunteers aged 25 ≤ 39 years, 5 males and 5 females, were recruited.