Macrophage P2Y12 regulates iron transport and its inhibition protects against atherosclerosis.

Introduction: Iron retention is commonly observed in atherosclerotic plaques and is believed to be detrimental to atherosclerosis. Platelet P2Y12 is a target of antiplatelet therapy in preventing thrombotic complications of atherosclerosis. The protective effect of P2Y12 on hematopoiesis reported by our previous work implies the involvement of P2Y12 in iron metabolism.

Shared genetic architecture of psychiatric disorders and hemorrhoidal disease: a large-scale genome-wide cross-trait analysis.

Background: The genetic association between psychiatric disorders and hemorrhoidal disease (HEM) is still not well known. The work aims to investigate their comorbidity at a genetic level.

Methods: Utilizing recent large-scale genome-wide association studies (GWAS), we investigated the genetic overlap at the single nucleotide polymorphism (SNP), gene, and molecular level between depression and HEM, bipolar disorder (BD) and HEM, neuroticism and HEM, as well as schizophrenia (SCZ) and HEM.

Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma.

Background: B-cell non-Hodgkin lymphoma (B-NHL) is the most common type of lymphoma and is significantly heterogeneous among various subtypes. Despite of considerable advancements in treatment strategies for B-NHL, the prognosis of relapsed/refractory patients remains poor.

Main Text: It has been indicated that epigenetic dysregulation is critically associated with the pathogenesis of most hematological malignancies, resulting in the clinical targeting of epigenetic modifications.

Stabilizing Metal Coating on Flexible Devices by Ultrathin Protein Nanofilms.

The significant modulus difference between a metal coating and a polymer substrate leads to interface mismatches, seriously affecting the stability of flexible devices. Therefore, enhancing the adhesion stability of a metal layer on an inert polymer substrate to prevent delamination becomes a key challenge. Herein, an ultrathin protein nanofilm (UPN), synthesized by disulfide-bond-reducing protein aggregation, is proposed as a strong adhesive layer to enhance adhesion between polymer substrate and metal coating.

The dynamic immune response of the liver and spleen in leopard coral grouper () to infection based on transcriptome analysis.

Leopard coral grouper () is one of the most important cultured fish in the Pacific and Indian oceans. is a serious pathogen causing serious skin ulceration and high mortality in . To gain more insight into the tissue-specific and dynamic immune regulation process of in response to infection, RNA sequencing (RNA-seq) was used to examine the transcriptome profiles in the spleen and liver at 0, 6, 12, 24, 48, and 72 h post-infection.

Functional traits of macrobenthos substantially indicated habitat change from the invasive saltmarsh to introduced mangrove.

Mangrove afforestation is usually thought to be beneficial to mitigate the degradation and loss of mangroves. In Southern China, planting mangroves with the introduced Sonneratia apetala is also supportive to remove the invasive Spartina alterniflora. However, the influence of mangrove afforestation dominated by introduced species on macrobenthos, a vital joint of energy flow and nutrient cycling in mangroves, remains unclear.

FN-1501 Inhibits Diffuse Large B-Cell Lymphoma Tumor Growth by Inducing Cell Cycle Arrest and Apoptosis.

Background: Due to its high degree of aggressiveness, diffuse large B-cell lymphoma (DLBCL) presents a treatment challenge because 30% to 50% of patients experience resistance or relapse following standard chemotherapy. FN-1501 is an effective inhibitor of cyclin-dependent kinases and Fms-like receptor tyrosine kinase 3.

Objective: This study aimed to examine the anti-tumor impact of FN-1501 on DLBCL and clarify its molecular mechanism.

Review on Catalytic Meinwald Rearrangement of Epoxides.

The past few decades have witnessed tremendous development within epoxides. Among the many known reactions involving epoxide, Meinwald rearrangements represent one of the most important and attractive approaches, which can transform epoxides into versatile carbonyl compounds. Given the high efficiency of this protocol, substantial efforts have been made by researchers by utilizing multiple catalyst systems.

controls stem strength by positively regulating the biosynthesis of cell wall components in L.

Lodging presents a significant challenge in cultivating high-yield crops with extensive above-ground biomass, yet the molecular mechanisms underlying this phenomenon in the family remain largely unexplored. In this study, we identified a gene, (), which encodes a MYELOBLASTOSIS (MYB) family transcription factor, from a lodging-affected EMS mutant. The suppression of expression in pepper led to notable stem lodging, reduced thickness of the secondary cell wall, and decreased stem strength.

A Novel AIE-Active Salicylaldehyde-Schiff Base Probe with Carbazole Group for Al Detection in Aqueous Solution.

A donor-acceptor Schiff-base fluorescent probe BKS with chelation enhanced fluorescence (CHEF) mechanism was designed and synthesized via benzophenone(Acceptor), salicylaldehyde and carbazole(Donor) for Al detection, which exhibited typical aggregation-induced emission (AIE) characteristic. BKS probe could provide outstanding selectivity to Al with a prominent fluorescence "turn-on" at 545 nm in a wide pH range from 2 to 11. By the Job's plot, the binding stoichiometry ratio of probe BKS to Al was determined 1:1.

Computational Modeling Interpretation Underlying Elevated Risk-Taking Propensity in the Dynamic Risky Investment Process of Non-Labor Income.

Introduction: Money source influences risk-taking behaviors. Although studies consistently indicated that individuals demonstrate a higher propensity to make risky investments when utilizing non-labor income as opposed to labor income, explanations as to why non-labor income leads to continuously blowing money into risky investments are scarce.

Methods: The current study leverages a computational modeling approach to compare the differences in the dynamic risk investment process among individuals endowed with income from different sources (ie, non-labor income vs labor income) to understand the shaping force of higher risk-taking propensity in individuals with non-labor income.

IGF2 promotes the differentiation of chicken embryonic myoblast by regulating mitochondrial remodeling.

Skeletal muscle is crucial for animal movement and posture maintenance, and it serves as a significant source of meat in the livestock and poultry industry. The number of muscle fibers differentiated from myoblast in the embryonic stage is one of the factors determining the content of skeletal muscle. Insulin-like growth factor 2 (IGF2), a well-known growth-promoting hormone, is crucial for embryonic and skeletal muscle growth and development.

Fabrication of Large-Area Nanostructures Using Cross-Nanoimprint Strategy.

Nanostructures with sufficiently large areas are necessary for the development of practical devices. Current efforts to fabricate large-area nanostructures using step-and-repeat nanoimprint lithography, however, result in either wide seams or low efficiency due to ultraviolet light leakage and the overflow of imprint resin. In this study, we propose an efficient method for large-area nanostructure fabrication using step-and-repeat nanoimprint lithography with a composite mold.

MRI-based pedicle bone quality score: correlation to quantitative computed tomography bone mineral density and its role in quantitative assessment of osteoporosis.

Background Context: Bone quality in the pedicle region generally determines screw pullout strength, insertion torque, and vertebral body loading characteristics. Dual-energy X-ray absorptiometry (DEXA), as the gold standard for evaluating bone mineral density (BMD), cannot measure the BMD of specific parts, such as pedicle, and DEXA is limited in many ways. Recent studies have shown a correlation between the magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score and BMD measured using DEXA or quantitative computed tomography (QCT).

Lysine 2-hydroxyisobutyrylation proteomics analyses reveal the regulatory mechanism of CaMYB61-CaAFR1 module in regulating stem development in Capsicum annuum L.

Plant stems constitute the most abundant renewable resource on earth. The function of lysine (K)-2-hydroxyisobutyrylation (K), a novel post-translational modification (PTM), has not yet been elucidated in plant stem development. Here, by assessing typical pepper genotypes with straight stem (SS) and prostrate stem (PS), we report the first large-scale proteomics analysis for protein K to date.

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.

Rich data from large biobanks, coupled with increasingly accessible association statistics from genome-wide association studies (GWAS), provide great opportunities to dissect the complex relationships among human traits and diseases. We introduce BADGERS, a powerful method to perform polygenic score-based biobank-wide association scans. Compared to traditional approaches, BADGERS uses GWAS summary statistics as input and does not require multiple traits to be measured in the same cohort.

Application of stem cells in the study of developmental and functional toxicity of endodermal-derived organs caused by nanoparticles.

Nanoparticles have unique properties that make them useful in biomedicine. However, their extensive use raises concerns about potential hazards to the body. Therefore, it is crucial to establish effective and robust toxicology models to evaluate the developmental and functional toxicity of nanoparticles on the body.

Pediatric incarcerated inguinal hernia: Traditional open or laparoscopic-assisted approach?

The objective of this study was to compare the safety and efficacy of laparoscopic-assisted surgery and traditional open surgery for pediatric incarcerated inguinal hernia. A total of 58 pediatric patients with indirect incarcerated inguinal hernia between January 2014 and January 2020 were included in this study. The patients were divided into 2 groups; observational group who underwent laparoscopic-assisted surgery (n = 36), and a control group who underwent traditional open surgery (n = 22).

Integrative analyses of genetic characteristics associated with skeletal endothelial cells.

The osseous vascular endothelium encompasses a vast intricate framework that regulates bone remodeling. Osteoporosis, an age-associated systemic bone disease, is characterized by the degeneration of the vascular architecture. Nevertheless, the precise mechanisms underpinning the metamorphosis of endothelial cells (ECs) with advancing age remain predominantly enigmatic.

The impact of past temporal discounting on mental health: Opposite effects of positive and negative event aftertastes over time: Aftertaste and time.

Background: Time frees people from bereavement, but also fades childhood happiness, these dynamics can be understood through the framework of past temporal discounting (PTD), which refers to the gradual decrease in affect intensity elicited by recalling positive or negative events over time. Despite its importance, measuring PTD has been challenging, and its impact on real-life outcomes, such as mental health remains unknown.

Method: Here, we employed a longitudinal tracking approach to measure PTD in healthy participants ( = 210) across eight time points.

Comprehensive analysis of single cell and bulk data develops a promising prognostic signature for improving immunotherapy responses in ovarian cancer.

The tumor heterogeneity is an important cause of clinical therapy failure and yields distinct prognosis in ovarian cancer (OV). Using the advantages of integrated single cell RNA sequencing (scRNA-seq) and bulk data to decode tumor heterogeneity remains largely unexplored. Four public datasets were enrolled in this study, including E-MTAB-8107, TCGA-OV, GSE63885, and GSE26193 cohorts.