SPIRIT: Structural Entropy Guided Prefix Tuning for Hierarchical Text Classification.

Hierarchical text classification (HTC) is a challenging task that requires classifiers to solve a series of multi-label subtasks considering hierarchical dependencies among labels. Recent studies have introduced prompt tuning to create closer connections between the language model (LM) and the complex label hierarchy. However, we find that the model's attention to the prompt gradually decreases as the prompt moves from the input to the output layer, revealing the limitations of previous prompt tuning methods for HTC.

Effects of Wx, SSIIa and FLO2 alleles and their interactions on the formation of multi-scale structures of rice starch.

The multi-scale structures of rice starches from 16 recombinant inbred lines and their parents with different combinations of Wx, SSIIa and FLO2 alleles were investigated. Results indicated that the starch multi-scale structures were significantly affected by genotype, environment and genotype × environment interaction. Wx, SSIIa and FLO2 alleles and their interactions significantly affected the starch fine structure.

A review of the 's intervention mechanism and clinical application in ischemic stroke.

Background: (BC), also named Niuhuang in Chinese, is utilized as a resuscitation drug in Traditional Chinese Medicine (TCM) for the treatment of neurological disorders. Ischemic stroke (IS) is a significant global public health issue that currently lacks safe and effective therapeutic drugs. Ongoing efforts are focused on identifying effective treatment strategies from Traditional, Complementary, and Integrative Medicine.

White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review.

Background: Assessing various types of dysfunction in cerebral palsy is a key factor in the treatment and rehabilitation of patients. The objective of this study was to use meta-analysis and systematic review to identify the specific white matter lesions and DTI metrics strongly associated with various types of dysfunction in cerebral palsy.

Methods: We conducted a literature search of PubMed, Embase, Cochrane Library and Web of Science databases to identify trials published that had evaluated the correlation between DTI metrics in sensorimotor pathways and function scores in cerebral palsy.

Graph-Based Deep Learning Models for Thermodynamic Property Prediction: The Interplay between Target Definition, Data Distribution, Featurization, and Model Architecture.

In this contribution, we examine the interplay between target definition, data distribution, featurization approaches, and model architectures on graph-based deep learning models for thermodynamic property prediction. Through consideration of five curated data sets, exhibiting diversity in elemental composition, multiplicity, charge state, and size, we examine the impact of each of these factors on model accuracy. We observe that target definition, i.

Oxygen Dimerization-Driven Cation Migration Induces Voltage Hysteresis in Disordered Rocksalt Cathodes.

Despite the potential to increase the energy limit of Li-rich cathodes by using oxygen redox, its practicality has been limited by the accompanying structural changes and voltage hysteresis. While voltage hysteresis is commonly associated with transition metal (TM) migration and oxygen dimerization, the specific contribution of each is unclear. We provide a mechanistic insight into how each of these changes induces hysteresis in a representative Li-rich disordered rocksalt cathode, LiMnTiO.

Genetic Diversity and Genome-Wide Association Study of Total Phenolics, Flavonoids, and Antioxidant Properties in Potatoes ( L.).

Genetic diversity of nutritional quality traits is crucial for potato breeding efforts to develop better varieties for the diverse market demands. In this study, the genetic diversity of 104 potato genotypes was estimated based on nutritional quality traits such as color parameters, total phenolic content, total flavonoid content, 2,2-Diphenyl-1-picrylhydrazyl (DPPH), and 2,2-azino-bis-(3-ethylbezothiazoline-6-sulphonic acid) radical scavenging potential across two environments. The results indicated that environment II, Hangzhou 2020, exhibited higher bioactive compounds and antioxidant properties than environment I, Hangzhou 2019.

Design and evaluation of collagenase-loaded nanoparticles for mechanical intervention of orthotopic hepatocellular carcinoma in rat model.

Altered tissue mechanics is vital for cancer development and malignancy, whether targeting the mechanical microenvironment could retard the initiation and progression of tumor is less explored. In this study, an orthotopic hepatocellular carcinoma (HCC) rat model was constructed to reproduce the mechanical and pathophysiological microenvironment of HCC development. LpMSN@CLG, a liver-targeted (L) and pH-sensitive (p) mesoporous silica nanoparticle (MSN) encapsulated with collagenase type-I (CLG), and DOX-LpMSN@CLG, on the basis of LpMSN@CLG, encapsulated with CLG and doxorubicin (DOX), were prepared to reduce matrix stiffness by degrading collagen in liver and HCC tumor.

Stretchable terahertz metasurface based on laser induced graphene for contactless deformation sensing.

In this paper, a 1D stretchable terahertz (THz) metasurface based on laser-induced graphene (LIG) for deformation sensing is developed with low cost, good sensitivity and robustness. After the LIG metasurface is fabricated by laser-direct writing on a polyimide film, it is divided into columns and bonded to a medical polyurethane (PU) tape, thus endowed with high elasticity due to the excellent flexibility of PU. Because LIG supports surface plasmon polaritons in the THz band, a plasmonic resonance is introduced in the reflection spectrum and red shifts with lateral stretching.

Chiral terahertz metasurface with asymmetric transmission, polarization conversion and circular dichroism.

A tri-layer chiral metasurface with multi-functions of asymmetric transmission (AT), polarization conversion (PC) and circular dichroism (CD) is proposed in the terahertz (THz) range. Simulation results show that the metasurface is able to realize AT with more than 90% efficiency and PC fractional bandwidth of 80% over a frequency range of 0.15 to 0.

Biomaterial-mediated delivery of traditional Chinese medicine ingredients for spinal cord injury: a systematic review.

Objective: Biomaterials loaded with ingredients derived from traditional Chinese medicine (TCM) are viewed as a promising strategy for treating spinal cord injury (SCI). However, a comprehensive analysis of the existing literature on this topic has not yet been conducted. Therefore, this paper systematically reviews researches related to this approach, aiming to identify gaps and shortcomings in the field.

Multi-omics analyses reveal mechanism for high resistant starch formation in an indica rice SSIIIa mutant.

Soluble starch synthase IIIa (SSIIIa) is a key enzyme involved in amylopectin biosynthesis in rice, and deficiency of SSIIIa results in high content of resistant starch, which is benefit to human health. However, little is known about metabolic differences and carbon re-allocation in the seeds of the indica rice ss3a mutant. We found that SSIIIa deficiency impaired the storage of starch, but increased the soluble sugars, free amino acids and lipids.

Storage deterioration and detection of egg multi-scale structure: A review.

This review summarized the processes and mechanisms of deterioration in different components of eggs during storage. The mechanisms linked to reduced glycosylation, structural decay, and ovomucin degradation during egg-white thinning were elucidated, along with the weakening of lysozyme-ovomucin interactions. The degradation and S-conformation transformation of ovalbumin were studied, and the potential application of solubility-viscosity theory in egg-white thinning was discussed.

Automated kapok fiber-based pipette-tip solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry for rapid and sensitive analysis of tyrosine kinase inhibitors in plasma.

This study delineates the development of a novel automated pipette-tip solid-phase extraction (SPE) methodology, employing kapok fiber as a naturally efficient and cost-effective adsorbent for the selective extraction of eleven tyrosine kinase inhibitors (TKIs) from plasma. The uniqueness of this method lies in its assembly, where kapok fibers are ingeniously wrapped around a stainless-steel spring within the pipette tip, ensuring an obstruction-free central space for effortless solution aspiration and dispensation. This design significantly minimizes backpressure, enhancing operational efficiency and ensuring compatibility with pipettors, including the implementation of an electric pipettor to streamline the sample preparation process and facilitate automation.

Oxygen-dependent regulation of F-box proteins in Toxoplasma gondii is mediated by Skp1 glycosylation.

A dynamic proteome is required for cellular adaption to changing environments including levels of O, and the SKP1/CULLIN-1/F-box protein/RBX1 (SCF) family of E3 ubiquitin ligases contributes importantly to proteasome-mediated degradation. We examine, in the apicomplexan parasite Toxoplasma gondii, the influence on the interactome of SKP1 by its novel glycan attached to hydroxyproline generated by PHYa, the likely ortholog of the HIFα PHD2 oxygen-sensor of human host cells. Strikingly, the representation of several putative F-box proteins (FBPs) is substantially reduced in PHYaΔ parasites grown in fibroblasts.

Longitudinal trajectories of blood glucose and 30-day mortality in patients with diabetes mellitus combined with acute myocardial infarction: A retrospective cohort analysis of the MIMIC database.

Background: Although blood glucose changes have been suggested to be a potential better target for clinical control than baseline blood glucose levels, the association of blood glucose changes with the prognosis in acute myocardial infarction (AMI) patients with diabetes mellitus (DM) is unclear. Herein, this study aimed to investigate association of short-term longitudinal trajectory of blood glucose with 30-day mortality in this population.

Methods: Data of AMI patients with DM were extracted from the Medical Information Mart for Intensive Care (MIMIC) database in 2003-2019 in this retrospective cohort study.

The function of juvenile-adult transition axis in female sexual receptivity of .

Female sexual receptivity is essential for reproduction of a species. Neuropeptides play the main role in regulating female receptivity. However, whether neuropeptides regulate female sexual receptivity during the neurodevelopment is unknown.

Stereo-Active Lone Pairs Induced Second Harmonic Generation Responses and Electrocatalytic Activity in Hybrid Material.

The lone pair electrons in the electronic structure of molecules have been a prominent research focus in chemistry for more than a century. Stable s lone pair electrons significantly influence material properties, including thermoelectric properties, nonlinear optical properties, ferroelectricity, and electro(photo)catalysis. While major advances have been achieved in understanding the influence of lone pair electrons on material characteristics, research on this effect in organic-inorganic hybrid materials is in its initial stage.

Simultaneous effervescence-assisted microextraction and magnetic adsorbent generation for rapid and cost-effective organochlorine pesticides analysis.

This study introduced an innovative magnetic effervescence-assisted microextraction method, streamlining the preparation of effervescent tablets through a one-pot method that blends a CO donor (NaCO) and an H donor (NaHPO) with bare magnetic particles (FeO) and an adsorbent (hydroxylated multi-walled carbon nanotubes), followed by pressing. During the extraction process, the bare magnetic particles and adsorbent undergo in-situ self-assembly to create a magnetic adsorbent. The effervescence generates bubbles that enhance effective extraction and magnetism facilitates the easy separation of the magnetic adsorbent from the sample solution, completing the process within 4 min.

Advances in Chromatographic and Mass Spectrometric Techniques for Analyzing Reducing Monosaccharides and Their Phosphates in Biological Samples.

Reducing monosaccharides and their phosphates are critical metabolites in the central carbon metabolism pathway of living organisms. Variations in their content can indicate abnormalities in metabolic pathways and the onset of certain diseases, necessitating their analysis and detection. Reducing monosaccharides and their phosphates exhibit significant variations in content within biological samples and are present in many isomers, which makes the accurate quantification of reducing monosaccharides and their phosphates in biological samples a challenging task.

Tetramethylpyrazine alleviates ferroptosis and promotes functional recovery in spinal cord injury by regulating GPX4/ACSL4.

Objective: Tetramethylpyrazine (TMP) has been demonstrated to alleviate neuronal ferroptosis following spinal cord injury (SCI), thereby promoting neural repair. However, the precise underlying mechanisms remain elusive.

Methods: The SCI model was established using a modified version of Allen's method.

Conditional chemoconnectomics (cCCTomics) as a strategy for efficient and conditional targeting of chemical transmission.

Dissection of neural circuitry underlying behaviors is a central theme in neurobiology. We have previously proposed the concept of chemoconnectome (CCT) to cover the entire chemical transmission between neurons and target cells in an organism and created tools for studying it (CCTomics) by targeting all genes related to the CCT in . Here we have created lines targeting the CCT in a conditional manner after modifying GFP RNA interference, Flp-out, and CRISPR/Cas9 technologies.

Rechargeable Zn-HO hydrolysis battery for hydrogen storage and production.

Reactive metals hydrolysis offers significant advantages for hydrogen storage and production. However, the regeneration of common reactive metals (e.g.

Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons.

Spinal cord injury (SCI) usually induces profound microvascular dysfunction. It disrupts the integrity of the blood-spinal cord barrier (BSCB), which could trigger a cascade of secondary pathological events that manifest as neuronal apoptosis and axonal demyelination. These events can further lead to irreversible neurological impairments.