Publications by authors named "Bowen Chu"

Article Synopsis
  • The study focuses on identifying genetic risk factors for acute viral respiratory infections (ARI) and integrating traditional Chinese medicine (TCM) in their prevention through multi-omics analysis across various global populations.
  • Key susceptibility risk loci for influenza and COVID-19 were discovered, including COL15A1 in Europeans, and MAN1A2 and RAB1A in East Asians, highlighting the genetic diversity in ARI susceptibility.
  • Potential TCMs were identified to target the druggable key susceptibility loci, emphasizing the importance of genetic studies in informing drug development and preventive strategies for ARI.
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Article Synopsis
  • The innate constitution is key in understanding disease mechanisms and tumor development, as highlighted by the theory of five movements and six climates.
  • Previous research shows a link between this theory and tumor types, suggesting its use in precision medicine for oncology.
  • This study aims to analyze the biological traits of different constitutions in a pan-cancer cohort and identify suitable anti-tumor drugs, leveraging data from various sources and machine learning techniques.
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Air pollution exerts crucial influence on crop yields and impacts regional and global food supplies. Here we employ a statistical model using satellite-based observations and flexible functional forms to analyse the synergistic effects of reductions in ozone and aerosols on China's food security. The model consistently shows that ozone is detrimental to crops, whereas aerosol has variable effects.

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Background: Recently, there has been a great deal interest in cuproptosis, a form of programmed cell death that is mediated by copper. The specific mechanism through which cuproptosis-related genes impact the development of colorectal cancer (CRC) remains unknown.

Methods: Here, we combined bulk RNA-seq with scRNA-seq to investigate the CRGs functions within CRC.

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The United States of America (USA) was afflicted by extreme heat in the summer of 2021 and some states experienced a record-hot or top-10 hottest summer. Meanwhile, the United States was also one of the countries impacted most by the coronavirus disease 2019 (COVID-19) pandemic. Growing numbers of studies have revealed that meteorological factors such as temperature may influence the number of confirmed COVID-19 cases and deaths.

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As a result of the pressure from population explosion, agricultural land resources require further protecting and rationally utilizing. Intercropping technique has been widely applied for agricultural production to save cultivated area, improve crop quality, and promote agriculture economy. In this study, we employed high-performance liquid chromatography (HPLC) and ultraviolet-visible spectroscopy (UV-vis) combined with chemometrics for determination and qualitative evaluation of several kinds of intercropping system with Gentiana rigescens Franch.

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Gentisides are a class of chemical compounds which is considered as potential therapeutic substance for treatment of neurodegenerative disorders. The heat reflux extraction conditions were optimized for seven kinds of gentisides from the root and rhizome of Gentiana rigescens Franch. ex Hemsl.

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