Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells.

Although bone morphogenetic protein 2 (BMP2) can induce chondrogenic differentiation of mesenchymal stem cells (MSCs), its induction of endochondral ossification limits the application of BMP2-based cartilage regeneration. Here, we clarified the mechanisms of BMP2-induced endochondral ossification of MSCs. and chondrogenic, osteogenic, and angiogenic differentiation models of MSCs were constructed.

TiCT-Based Cross-Scale Laminated Structural Structures: Enabling Sub-Wavelength Impedance Modulation and Underwater Broadband Sound Absorption.

Designing underwater acoustic absorbing materials with sub-wavelength thickness in the mid-to-low frequency range (400-4000 Hz) remains a challenge, especially for broad frequency applications. Most current designs focus on a single spatial scale, limiting their frequency range. To address this, a composite material (MPSFn-SBR) made of TiCT-polyvinyl alcohol self-assembled films(MPSFn) and styrene-butadiene rubber (SBR) is designed, featuring a cross-scale laminated structure.

Navigating the crossroads: A case study on legal values perspectives of religious attire expression in the workplace.

Background: The phenomenon of prohibiting employees from expressing religious attire in the workplace involves a complex interplay of different parties and issues related to human rights protection. Addressing and resolving this issue holds significant implications for advancing the cause of global religious freedom.

Objective: Through an analysis of common features in eleven representative cases from English and American legal systems, the author further discusses the challenges faced by employees expressing their religious attire in the workplace, and the institutional and societal issues reflected through these decisions.

Cooperative Magnetic Interfacial Microrobot Couplefor Versatile Non-Contact Biomedical Applications.

Magnetic interfacial microrobots are increasingly recognized as a promising approach for potential biomedical applications ranging from electronic functionalization to minimally invasive surgery and targeted drug delivery. Nevertheless, existing research faces challenges, including less cooperative interactions, contact-based cargo manipulation, and slow transport velocity. Here, the cooperative magnetic interfacial microrobot couple (CMIMC) is proposed to address the above challenges.

A hybrid single quantum dot coupled cavity on a CMOS-compatible SiC photonic chip for Purcell-enhanced deterministic single-photon emission.

The ability to control nonclassical light emission from a single quantum emitter by an integrated cavity may unleash new perspectives for integrated photonic quantum applications. However, coupling a single quantum emitter to cavity within photonic circuitry towards creation of the Purcell-enhanced single-photon emission is elusive due to the complexity of integrating active devices in low-loss photonic circuits. Here we demonstrate a hybrid micro-ring resonator (HMRR) coupled with self-assembled quantum dots (QDs) for cavity-enhanced deterministic single-photon emission.

Perillaldehyde ameliorates sepsis-associated acute kidney injury via inhibiting HSP90AA1-mediated ferroptosis and pyroptosis: Molecular structure and protein interaction of HSP90AA1.

Heat shock protein 90α (HSP90AA1) is a molecular chaperone involved in a variety of cellular processes. Special attention is paid to how perillaldehyde ameliorates kidney injury by inhibiting HSP90AA1-mediated iron and pyrotoxicity, and in-depth analysis of the molecular structure and protein interactions of HSP90AA-1. The interaction between perillaldehyde and HSP90AA1 and the effect of perillaldehyde on the molecular structure of HSP90AA1 were analyzed by molecular docking and surface plasmon resonance technique.

Study on the Mechanical Properties, Tensile Performance, Hydration Heat, and Microstructure of VAE-Modified Rubber Mortar.

This study builds on the practice of using waste rubber to improve the ductility of cement mortar and further explores the potential of vinyl acetate-ethylene (VAE) in enhancing the ductility of rubber cement mortar (RM). It systematically analyzes the effects of VAE on the workability, mechanical properties, crack resistance, and microstructure of RM. Additionally, isothermal calorimetry was employed to investigate the mechanism of VAE's influence on cement hydration heat.

and Regulate Heat Stress Response in Hu Sheep Through Lipid Metabolism via m6A Modification.

In an established hepatocyte lipid deposition heat stress model, the expression levels of and were significantly upregulated ( < 0.05), indicating that and play important roles in the process of lipid deposition heat stress in hepatocytes. Transcriptome and metabolome analyses showed that lipid deposition heat stress had significant effects on the linoleic acid, linolenic acid, glycerophospholipid, and arachidonic acid metabolic pathways in hepatocytes.

Low-power edge detection based on ferroelectric field-effect transistor.

Edge detection is one of the most essential research hotspots in computer vision and has a wide variety of applications, such as image segmentation, target detection, and other high-level image processing technologies. However, efficient edge detection is difficult in a resource-constrained environment, especially edge-computing hardware. Here, we report a low-power edge detection hardware system based on HfO-based ferroelectric field-effect transistor, which is one of the most potential non-volatile memories for energy-efficient computing.

Co-precipitation fabrication of cellulose/chitosan-aniline grafted composites for efficient removal of Pb ions from aqueous solution.

Heavy metal ions, are non-biodegradable, high toxic tendency, and have serious hazardous effects on the health of humans. Then, removing them from the environment using different techniques is necessary. Several routes are expensive, low-efficient, and require a long time to achieve adsorption equilibrium.

Selenium nanoparticles decorated by fucoidan induce ferroptosis in HepG2 cells.

Unlike apoptosis, necrosis and autophagy, ferroptosis is a novel type of regulated cell death, and the mechanism by which selenium nanoparticles induce ferroptosis in cancer cells has rarely been investigated. To investigate the mechanism of inhibition of HepG2 cell proliferation by fucoidan-selenium nanoparticles (FD-SeNPs) by inducing ferroptosis. The mechanism was explored by detecting ROS, MDA, GSH and Fe and utilizing TEM and Western blot assay.

Who still suffers? Effects of COVID-19 stressful experiences on somatic symptoms and anxious mood moderated by diurnal cortisol: A daily diary study.

This daily diary study drew on the allostatic load model to examine the predictive effect of COVID-19 stressful experiences (CSE) on somatic symptoms and anxious mood, as well as applying the biological sensitivity to context model to explore whether diurnal cortisol moderated the above associations. A total of 101 Chinese college students retrospectively reported CSE in October 2020, followed by 5-day diary reports on somatic symptoms and anxious mood in November 2020, with salivary cortisol collected on Days 2 to 4 to measure cortisol awakening response (CAR), diurnal cortisol slope (DCS), and daily cortisol output (area under the curve with respect to ground, AUC). Results of multilevel models showed that greater CSE predicted more somatic symptoms but not anxious mood, which was only observed at flatter CAR, flatter DCS, or low AUC.

Utilizing reconstruction achieves ultrastable water electrolysis.

The dissolution of active atoms under operating potential will lead to a decline in their oxygen evolution reaction (OER) performance, thus preventing the current highly active catalysts from being practically applicable in industrial water electrolysis. Here, we propose a sequential leaching strategy to utilize the dynamic restructuring and enhance the chemical bond strength for highly active and stable OER. Modeling on nickel-iron sulfides (NiFe-S), we introduced and utilized foreign Mo dopant preleaching as the sacrificial agent to alleviate the oxidation corrosion of partial M─S bonds.

Longitudinal Study on Puberty Onset and Adolescent Obesity - Suzhou City, Jiangsu Province, China, 2012-2022.

What Is Already Known About This Topic?: The early onset of puberty increases the risk of cardiovascular diseases. Limited research has focused on the association between the onset of puberty, based on sudden increases in height, and obesity in late adolescence.

What Is Added By This Report?: This report assessed the age at take-off and age at peak height velocity for children and adolescents in China from 2012 to 2020.

Relationship Between Internet Use and Cognitive Function Among Middle-Aged and Older Chinese Adults: 5-Year Longitudinal Study.

Background: Cognitive decline poses one of the greatest global challenges for health and social care, particularly in China, where the burden on the older adult population is most pronounced. Despite the rapid expansion of internet access, there is still limited understanding of the long-term cognitive impacts of internet use among middle-aged and older adults.

Objective: This study aims to explore the association between internet use and age-related cognitive decline among middle-aged and older Chinese adults.

Light-Triggered Droplet Gating Strategy Based on Janus Membrane Fabricated by Femtosecond Laser.

The characteristics of the directed transport of liquids based on Janus membranes play a crucial role in practical applications in energy, materials, physics, chemistry, medicine, biology, and other fields. Although extensive progress has been made, it is still difficult to realize the accurate controllability of liquid directional transmembrane transport. The current gating strategies for the directed transport of liquids based on Janus membranes still have some limitations: (a) using magnetic fluid may cause contamination due to the addition of new substances and (b) utilizing hydrophobicity/hydrophilicity conversion of titanium dioxide requires a long switching time (over 30 min).

The molecular regulated mechanism of METTL3 and FTO in lipid metabolism of Hu sheep.

Background: Balanced lipid metabolism can improve the growth performance and meat quality of livestock. The m6A methylation-related genes METTL3 and FTO play important roles in animal lipid metabolism; however, the mechanism through which they regulate lipid metabolism in sheep is unclear.

Results: We established lipid deposition models of hepatocytes and preadipocytes in Hu sheep.

An Internet-Based Developmental Home Care Support Program Improved Maternal Psychological Symptoms and Infant Growth: A Randomized Controlled Trial.

Objective: To examine the effects of an internet-based Developmental Home Care Support program (DHCSP) to reduce maternal psychological symptoms and improve preterm infants' physical growth outcomes.

Methods: A randomized controlled trial was conducted. The mother-infant dyads ( nm  = 34, np  = 40) were randomly assigned to either the DHCSP intervention group or the control group.

Prediction of heavy metal ion distribution and Pb and Zn ion concentrations in the tailing pond area.

The pollution caused by tailings ponds has resulted in ecological damage, with soil contamination significantly impacting the daily lives of residents in the vicinity of mining areas and the future development of mining areas. This study assesses the transport status of heavy metal pollution in tailings areas and predicts its impact on future pollution levels. This study focused on lead-zinc tailing ponds, exploring the spatial and chemical distribution characteristics of heavy metals based on the distributions of Pb, Zn, As, Cu, Cr, Cd, Hg, and Ge ions.

Association between breastfeeding duration and neurodevelopment in Chinese children aged 2 to 3 years.

Objective: The aim of this study was to explore the relationship between breastfeeding duration and neurodevelopment in children aged 2 to 3 years in a Chinese population.

Methods: This study was based on a cross-sectional survey. The data were from the National Nutrition and Health Systematic Survey for children in China which was conducted from 2019 to 2020.

Development and application of an intelligent nitrogen removal diagnosis and optimization framework for WWTPs: Low-carbon and stable operation.

Optimizing nitrogen removal is crucial for ensuring the efficient operation of wastewater treatment plants (WWTPs), but it is susceptible to variations in influent conditions and operational parameter constraints, and conflicts with the energy-saving and carbon emission reduction goals. To address these issues, this study proposes a hybrid framework integrating process simulation, machine learning, and multi-objective genetic algorithms for nitrogen removal diagnosis and optimization, aiming to predict the total nitrogen in effluent, diagnose nitrogen over-limit risks, and optimize the control strategies. Taking a full-scale WWTP as a case study, a process time-lag simulation-enhanced machine learning model (PTLS-ML) was developed, achieving R values of 0.