Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study.

Background: Clonal hematopoiesis of indeterminate potential (CHIP) was associated with diabetes and cardiovascular diseases (CVD). However, the effect of CHIP on CVD have not been evaluated among patients with diabetes, and whether maintaining the healthy indictors could mitigate the adverse influence was also unclear.

Methods: A total of 22,239 adults from the UK Biobank with diabetes and available whole-exome sequence data, and free of CVD were included.

Non-traditional risk factors for atrial fibrillation: epidemiology, mechanisms, and strategies.

Atrial fibrillation (AF) has become the pre-dominant arrhythmia worldwide and is associated with high morbidity and mortality. Its pathogenesis is intricately linked to the deleterious impact of cardiovascular risk factors, emphasizing the pivotal imperative for early detection and mitigation strategies targeting these factors for the prevention of primary AF. While traditional risk factors are well recognized, an increasing number of novel risk factors have been identified in recent decades.

Early-life famine exposure, genetic susceptibility and risk of MAFLD in adulthood.

Objectives: Early-famine exposure was reported to be associated with metabolic associated fatty liver disease (MAFLD); however, it has not been fully elucidated whether the gene-famine interaction exist in this association. We aimed to investigate the association between early-life famine exposure in different genetic risk stratifications and the risk of MAFLD in adulthood.

Design, Setting, Participants, And Measurements: The study included 8213 participants from the SPECT-China study.

Lead exposure and physical frailty in patients with type 2 diabetes mellitus: cross-sectional results from the METAL study.

Purpose: Chronic lead exposure continues to be a global environmental concern. Previous studies reported high levels of lead exposure in people with diabetes. Frailty is one of the vital comorbidities of type 2 diabetes mellitus (T2DM); however, researchers have not determined whether lead exposure is a risk factor for frailty in people with T2DM.

Accelerated biological aging, mediating amino acids, and risk of incident type 2 diabetes: a prospective cohort study.

Purpose: Aging plays an important role in type 2 diabetes mellitus (T2DM). But the association between accelerated biological age and T2DM, and the mechanisms underlying this association remains unclear. Thus, this study aimed to examine the associations of biological aging with T2DM, and explore the potential mediation effect of amino acids.

Joint effects of physical frailty and traditional cardiovascular risk factor control on cardiovascular disease in patients with diabetes.

Objectives: Physical frailty has been found to increase the risk of multiple adverse outcomes including cardiovascular disease (CVD) in diabetic patients, but whether this could be modified by traditional risk factor control remains unknown. We aimed to explore the joint and interaction effects of frailty and traditional risk factor control on the risk of CVD.

Design: A population-based cohort study.

Physical Frailty, Genetic Predisposition, and Incident Heart Failure.

Background: There is growing interest in the intersection of frailty and heart failure (HF); however, large-sample longitudinal studies in the general population are lacking.

Objectives: The goal of this study was to examine the longitudinal relationship between frailty and incident HF, and whether age and genetic predisposition could modify this association.

Methods: This prospective cohort study included 340,541 participants (45.

Association patterns of ketone bodies with the risk of adverse outcomes according to diabetes status.

Aim: To investigate the associations between ketone bodies (KB) and multiple adverse outcomes including cardiovascular disease (CVD), chronic kidney disease (CKD) and all-cause mortality according to diabetes status.

Methods: This prospective study included 222 824 participants free from CVD and CKD at baseline from the UK Biobank. Total KB including β-hydroxybutyrate, acetoacetate and acetone were measured by nuclear magnetic resonance.

Sweetened Beverages, Genetic Susceptibility, and Incident Atrial Fibrillation: A Prospective Cohort Study.

Background: An association between sweetened beverages and several cardiometabolic diseases has been reported, but their association with atrial fibrillation (AF) is unclear. We aimed to investigate the associations between consumption of sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB), and pure fruit juice (PJ) and risk of consumption with AF risk and further evaluate whether genetic susceptibility modifies these associations.

Methods: A total of 201 856 participants who were free of baseline AF, had genetic data available, and completed a 24-hour diet questionnaire were included.

Self-Reported Outdoor Light Exposure Time and Incident Heart Failure.

Background: A healthy lifestyle is an important factor for preventing heart failure. However, the association between outdoor light exposure time and heart failure is still unknown. The aim of this study was to examine the association between outdoor light exposure time and the incidence of heart failure.

Cardiovascular health, sleeping duration, and risk of mortality in current and former smokers.

Background And Aims: To investigate the associations of ideal cardiovascular health metrics (ICVHMs) with all-cause mortality among former and current smokers compared with never smokers.

Methods And Results: A total of 378,147 participants [mean age (SD) years: 56.3 (8.

Spatiotemporal dynamics of wetlands and their future multi-scenario simulation in the Yellow River Delta, China.

Wetlands, known as the "kidney of the earth", are an important component of global ecosystems. However, they have been changed under multiple stresses in recent decades, which is especially true in the Yellow River Delta. This study examined the spatiotemporal change characteristics of wetlands in the Yellow River Delta from 1980 to 2020 and predicted detailed wetland changes from 2020 to 2030 with the patch-generating land use simulation (PLUS) model under four scenarios, namely, the natural development scenario (NDS), the farmland protection scenario (FPS), the wetland protection scenario (WPS) and the harmonious development scenario (HDS).

SGLT2 inhibition, circulating metabolites, and atrial fibrillation: a Mendelian randomization study.

Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown promise in reducing the risk of atrial fibrillation (AF). However, the results are controversial and the underlying metabolic mechanism remains unclear. Emerging evidence implied that SGLT2 inhibitors have extra beneficial metabolic effects on circulating metabolites beyond glucose control, which might play a role in reducing the risk of AF.

Associations of artificially sweetened beverages, sugar-sweetened beverages, and pure fruit/vegetable juice with visceral adipose tissue mass.

Objective: To test the associations of sugar-sweetened beverage, artificially sweetened beverage, and pure fruit/vegetable juice consumption with visceral adipose tissue (VAT) mass at baseline and follow-up and to determine whether BMI and genetic risk of VAT mass modified the associations.

Methods: A total of 203,348 participants from UK Biobank with consumption data on three beverages were included. Participants were categorized into nonconsumers and consumers with >0-1, >1-2 and >2 L/week.

Associations of Sugar-Sweetened Beverages, Artificially Sweetened Beverages, and Pure Fruit Juice With Nonalcoholic Fatty Liver Disease: Cross-sectional and Longitudinal Study.

Objective: We aimed to test the associations of sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB), and pure fruit juice (PJ) consumption with the risk of nonalcoholic fatty liver disease (NAFLD).

Methods: Data for 136 277 UK Biobank participants who completed the dietary questionnaire and did not have a history of liver disease were included. Logistic regression was used for the cross-sectional setting where NAFLD was defined by a fatty liver index (FLI) ≥60.

Sweetened beverages and incident heart failure.

Aims: Recent studies have demonstrated the associations of the consumption of different beverages with cardiometabolic diseases, whereas no studies have investigated such associations in heart failure (HF). Thus, this study aimed to explore the associations of the consumption of sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and pure fruit/vegetable juices (PJs) with the risk of incident HF.

Methods And Results: This prospective cohort study included 209 829 participants in the UK Biobank who completed at least one 24-h diet questionnaire and who were free of baseline HF.

Association between Life's Essential 8 score and risk of premature mortality in people with and without type 2 diabetes: A prospective cohort study.

Aims: To evaluate the association of cardiovascular health (CVH), measured by Life's Essential 8 score, with the risk of premature mortality and to determine the patterns of CVH-related differences in life expectancy among people with and without type 2 diabetes (T2D).

Materials And Methods: This prospective study included 309,789 participants (age 56.6 ± 8.

Age-specific and sex-specific associations of visceral adipose tissue mass and fat-to-muscle mass ratio with risk of mortality.

Background: Limited studies have explored the association between visceral adipose tissue (VAT) mass and fat-to-muscle mass ratio (FMR) and mortality. We aimed to evaluate the sex-specific association of VAT and FMR with all-cause and cause-specific mortality by age.

Methods: A total of 438 896 participants (49.

Quantify the effects of groundwater level recovery on groundwater nitrate dynamics through a quasi-3D integrated model for the vadose zone-groundwater coupled system.

Groundwater level (GWL) recovery in some semiarid regions, attributed to mitigation countermeasures for groundwater depletion, potentially causes nitrate accumulated in the vadose zone to be introduced into the aquifer. However, the extent to which GWL recovery affects interactions between the vadose zone and saturated aquifers, migration pathways of soil nitrogen and groundwater nitrate dynamics have not been explicitly determined. This study established a quasi-3D feedback model for the vadose zone-groundwater coupled system in a typical GWL recovery area and quantitatively evaluated the effects of GWL recovery on nitrate-N leaching fluxes via the vadose zone and groundwater nitrate-N dynamics.

Impact of simulating real microplastics on toluene removal from contaminated soil using thermally enhanced air injection.

This paper investigated the impacts of various real microplastics (MPs), i.e., polyethylene (PE) and polyethylene terephthalate (PET) with different sizes (1000-2000 and 100-200 μm) and different dosages (0.

Thermal desorption optimization for the remediation of hydrocarbon-contaminated soils by a self-built sustainability evaluation tool.

Current thermal desorption practices of hydrocarbon-contaminated soils focus on remediation efficiency and cost, with little systematic assessment of the reuse value of treated soils. This study evaluated various integrated indices of treatment cost and reuse of treated soils at three desorption temperatures. Various typical engineering and ecological characteristics closely related to soil reusability were selected to analyze the changes in various treated soils, including shear strength, Atterberg limits, particle size distribution, permeability, soil carbon, and soil biomass.

Using soil erosion to locate nonpoint source pollution risks in coastal zones: A case study in the Yellow River Delta, China.

Soil erosion contributes greatly to nonpoint source pollution (NSP). We built a coastal NSP risk calculation method (CNSPRI) based on the Revised Universal Soil Loss Equation (RUSLE) and geospatial methods. In studies on the formation and transport of coastal NSP, we analysed the pollution impacts on the sea by dividing subbasins into the sea and monitoring the pollutant flux.

Evaluation of the effectiveness of VOC-contaminated soil preparation based on AHP-CRITIC-TOPSIS model.

Currently, several methods have been adopted for the laboratory preparation of artificial volatile organic compound (VOC) contaminated soils (VCSs). However, it remains unclear whether the prepared contaminated soils are homogenous. In this study, two representative VOCs, toluene and perchloroethylene, were separately mixed with a kaolin-based soil using six preparation methods.