Stacking Pressure Modulated Deposition and Dissolution of Zinc Anode.

Aqueous zinc-ion batteries (ZIBs) are emerging as a promising candidate for large-scale energy storage, offering enhanced safety and low costs. Nevertheless, the disordered growth of zinc dendrites has resulted in low coulombic efficiency and the dangers of short circuits, limiting the commercialization of ZIBs. In this study, a planar growth of zinc along the (002) direction is achieved by regulating the moderate initial stacking pressure during cell cycling and facilitating a larger zinc deposition particle size.

A Soft Nonpolar-Soluble Two-Dimensional Perovskite for General Construction of Mixed-Dimensional Heterojunctions.

Constructing mixed-dimensional heterojunctions through ion exchange between functional organic ammonium halides and the already-deposited bulk 3D perovskite films is a widely adopted strategy to effectively passivate and stabilize perovskite solar cells (PSCs). Such process poses challenges in precisely controlling the composition and distribution of the heterojunctions across the film, in particular for large-area applications. Here, a soft 2D perovskite based on tetrapheptyl-ammonium iodide (TPAI), noted as TPAPbI is reported.

Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases.

Asparagine endopeptidase (AEP), or legumain, is a cysteine protease implicated in various disorders, including atherosclerosis, cancers, neurodegenerative diseases, and inflammation. The development of AEP inhibitors has emerged as a promising therapeutic strategy to modulate AEP activity and slow disease progression. Various AEP inhibitors have been explored, encompassing small molecules, peptide-based, antibody-based, and natural inhibitors.

Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model.

Endometriosis is a refractory estrogen-dependent gynecological disease in which ovarian endometriosis(OE) is the most common, and the main cell components are endometrial epithelial cells and stromal cells. However, constructing ectopic endometrial epithelial cell models in basic studies is still challenging. In this study, we explored the feasibility and influencing factors of constructing and validating eutopic and ectopic endometrial organoid models of OE as in-vitro models.

Extracts of and relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress.

Solar dermatitis, a condition triggered by excessive exposure to ultraviolet B (UVB) radiation, results in inflammatory skin damage marked by erythema, edema, and epidermal injury. Portulaca oleracea (PO) and Patrinia scabiosaefolia (PS) have been traditionally used in dermatological treatments, though their mechanistic pathways in UVB-induced skin injury are not fully understood. In this study, a mouse model of UVB-induced solar dermatitis was employed to evaluate the therapeutic potential of combined PO and PS (POPS) extracts.

Retraction: Titanium dioxide nanoparticles induce mitochondria-associated apoptosis in HepG2 cells.

[This retracts the article DOI: 10.1039/C8RA05132A.].

Sustained Increases in Hydrofluorocarbon Emissions from China and Implications for Global Emissions.

Hydrofluorocarbons (HFCs), which are potent greenhouse gases and widely used as replacements for ozone-depleting substances, are controlled under the Montreal Protocol. China is considered an emission hot region of HFCs, however, the observations and emission quantifications are still insufficient. In this study, we report new high-frequency in situ observations of HFC-125, HFC-134a, and HFC-143a at the Changdao (CHD) station, whose emission sensitivity to northern China is higher than those of previously used stations to better quantify emissions.

Hemostatic effect of oxidized regenerated cellulose vs. topical tranexamic acid in total knee arthroplasty-a prospective randomized controlled trial.

Aims: This study compared the hemostatic effects and complications of oxidized regenerated cellulose (ORC) and topical TXA in total knee arthroplasty (TKA), thus providing a reference for the use of ORC as an alternative hemostatic agent to TXA in TKA.

Methods: A total of 105 patients were included in this study and randomized into blank control, ORC, and TXA groups. The primary outcomes were total blood loss, hemoglobin drop (Hb drop), transfusion rates, and incidence of thrombosis.

Visual detection of ciprofloxacin using a multi-emission ratiometric fluorescence sensor based on the molecularly imprinted polymers doped with terbium(III) ions.

Ciprofloxacin (CIP) is a commonly used antibiotic, but its abuse may cause bacterial resistance, posing a high risk to the environment and human health. Herein, based on the molecular imprinting technology, this study proposed a ratiometric fluorescence sensor employing the "post-doping" strategy, which aims to be rapid, selective, and visually easy-to-use for CIP detection to address antibiotic residues and environmental risks. Specifically, by exploiting the "antenna effect" of lanthanide metal ions (Ln), terbium (III) (Tb) chosen as a fluorescence-assisted functional monomer as well as the red emitting CdTe quantum dots (QDs) as the internal reference signal were introduced into multi-emission Tb-CdTe@SiO@MIPs (TbMIPs).

Efficacy of preoperative prophylactic application of betamethasone on postoperative nausea and vomiting in patients undergoing total knee arthroplasty: a prospective randomized controlled trial.

Background: The demand for total knee arthroplasty (TKA) is increasing, yet postoperative nausea and vomiting (PONV) significantly hinder patient recovery. Preoperative prophylactic administration of glucocorticoids can alleviate PONV, with betamethasone showing promising results in breast and cardiac surgeries. However, its efficacy in TKA patients remains unclear.

Symmetry Breaking in Rationally Designed Copper Oxide Electrocatalyst Boosts the Oxygen Reduction Reaction.

Oxygen reduction reaction (ORR) kinetics is critically dependent on the precise modulation of the interactions between the key oxygen intermediates and catalytic active sites. Herein, a novel electrocatalyst is reported, featuring nitrogen-doped carbon-supported ultra-small copper oxide nanoparticles with the broken-symmetry C coordination filed sites, achieved by a mild γ-ray radiation-induced method. The as-synthesized catalyst exhibits an excellent ORR activity with a half-wave potential of 0.

Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease.

Dopaminergic neurons in the substantia nigra pars compacta (SNpc) demonstrate regionally selective susceptibility in Parkinson's disease (PD) compared to those in the ventral tegmental area (VTA). However, the molecular mechanism for this distinct vulnerability remains unclear. Here, it is shown that Legumain, also known as asparagine endopeptidase (AEP), is activated in a subgroup of SRY-box transcription factor 6 /Aldehyde dehydrogenase 1 family member A1, (Sox6/ALDH1A1) neurons in the ventral tier of the SNpc and cleaves Sox6 and ALDH1A1, leading to repression of Special AT-rich sequence binding protein 1 (Satb1) that is a dimeric/tetrameric transcription factor specifically binding to AT-rich DNA sequences, and toxic dopamine metabolite accumulation.

Bioinspired Antireflective and Antifogging Surface for Highly Efficient and Stable Inverted Solar Cells.

Photovoltaic devices are essentially solar energy collectors that convert incident photons into charge carriers. However, light reflection losses and external factors (e.g.

Crouching bacteria, hidden tetA genes in natural waters: Intracellular damage via double persulfate activation (UVA/Fe/PDS) effectively alleviates the spread of antibiotic resistance.

In this study, we elucidated the chemical and biological inactivation mechanisms of peroxydisulfate (PDS) activated by UVA and Fe (UVA/Fe/PDS) in wild-type antibiotic-resistant bacteria (ARB) isolated from a river in Inner Mongolia. Among the screened wild-type ARB, the relative abundance of unidentified Enterobacteriaceae, Stenotrophomonas, and Ralstonia was high. A ratio of 1:1 for Fe and PDS under 18 W·m UVA radiation (sunny days) completely inactivated the environmental ARB isolates.

Simultaneously Modulating HIF-1α and HIF-2α and Optimizing Macrophage Polarization through the Biomimetic Gene Vector toward the Treatment of Osteoarthritis.

In osteoarthritis (OA), articular cartilage is continuously submerged in a hypoxic environment throughout life, and hypoxia-inducible factors (HIFs) play a crucial role in OA progression. Among the various HIF phenotypes, HIF-1α positively contributes to maintaining the stability of the articular cartilage matrix. In contrast, HIF-2α has a detrimental effect, leading to chondrocyte apoptosis and exacerbating inflammation.

Characteristics of China's coal mine methane emission sources at national and provincial levels.

Methane (CH) is the second most abundant greenhouse gas. China is the largest CH emitter in the world, with coal mine methane (CMM) being one of the main anthropogenic contributions. Thus, there is an urgent need for comprehensive estimates and strategies for reducing CMM emissions in China.

Effects of Evodiamine on Behavior and Hippocampal Neurons through Inhibition of Angiotensin-Converting Enzyme and Modulation of the Renin Angiotensin Pathway in a Mouse Model of Post-Traumatic Stress Disorder.

Post-traumatic stress disorder (PTSD) is a persistent psychiatric condition that arises following exposure to traumatic events such as warfare, natural disasters, or other catastrophic incidents, typically characterized by heightened anxiety, depressive symptoms, and cognitive dysfunction. In this study, animals subjected to single prolonged stress (SPS) were administered evodiamine (EVO) and compared to a positive control group receiving sertraline. The animals were then assessed for alterations in anxiety, depression, and cognitive function.

Research on domain ontology construction based on the content features of online rumors.

Online rumors are widespread and difficult to identify, which bring serious harm to society and individuals. To effectively detect and govern online rumors, it is necessary to conduct in-depth semantic analysis and understand the content features of rumors. This paper proposes a TFI domain ontology construction method, which aims to achieve semantic parsing and reasoning of the rumor text content.

Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer's disease.

Early onset familial Alzheimer's disease (FAD) with APP, PS1/2 (presenilins) mutation accounts for only a small portion of AD cases, and most are late-onset sporadic. However, majority of AD mouse models are developed to mimic the genetic cause of human AD by overexpressing mutated forms of human APP, PS1/2, and/or Tau protein, though there is no Tau mutation in AD, and no single mouse model recapitulates all aspects of AD pathology. Here, we report Thy1-ApoE4/C/EBPβ double transgenic mouse model that demonstrates key AD pathologies in an age-dependent manner in absence of any human APP or PS1/2 mutation.

Molecular imprinting-based triple-emission ratiometric fluorescence sensor with aggregation-induced emission effect for visual detection of doxycycline.

The development of high-performance sensors for doxycycline (DOX) detection is necessary because its residue accumulation will cause serious harm to human health and the environment. Here, a novel tri-emission ratiometric fluorescence sensor was proposed by using "post-mixing" strategy of different emissions fluorescence molecularly imprinted polymers with salicylamide as dummy template (DMIPs). BSA was chosen as assistant functional monomer, and also acted as sensitizers for the aggregation-induced emission (AIE) effect of DOX.

The deviation of farmers' willingness and behavior of domestic waste separation: a study on neighborhood effects and policy interventions.

Based on the perspective of combining informal and formal systems, this paper empirically explores the impact of neighborhood effects and policy interventions on the deviation of farmers' willingness and behavior of domestic waste separation (DWS) by using data from the China Land Economy Survey (CLES) and constructing a probit model. It should be explained that the neighborhood effect in this paper refers to the fact that the behavior of farmers is highly susceptible to the behavior of their neighbors in the process of production and living. The results of the study show that neighborhood effects and policy interventions have a significant negative impact on the deviation of farmers' willingness and behavior of DWS, respectively.