Publications by authors named "Bovenberg S"
Article Synopsis
- The study explores how glycemic variability (GV) affects pregnancy complications in women with type 1 diabetes during the pre- and periconception period, highlighting a gap in existing knowledge.
- Among 63 eligible women, 29 were included as their glucose data were analyzed through various metrics, revealing that a higher Average Daily Risk Range (ADRR) at conception correlated with greater complication scores.
- The findings suggest that the relationship between GV and complications varies based on the timing during pregnancy and the specific measurement metrics used.
Aim: To assess 1) the prevalence of children and adolescents with type 1 diabetes (T1D) changing from low-risk into borderline-high-risk lipid levels or from borderline-high-risk into high-risk lipid levels ('lose track of lipids') and 2) the power of a risk score including the determinants HbA1c, body mass index (BMI), gender, age, diabetes duration and ethnicity in predicting which patients lose track of lipids.
Methods: 651 children and adolescents with T1D were included in this longitudinal retrospective cohort study. Lipid dynamics and the impact of the risk score on losing track of lipids were evaluated.
Background: Early identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate the applicability of assessing skin advanced glycation end products (sAGEs) by skin autofluorescence (SAF) as a potential surrogate risk marker.
Methods: This study included a cross-sectional analysis of SAF in 77 patients with type 1 diabetes mellitus and 118 healthy controls across age categories (11-12, 13-14, 15-16, and 17-19 years old).
Aims: The aim of this study was to assess age-specific carotid intima-media thickness (cIMT) in children and adolescents with type 1 diabetes and to investigate associations between cIMT, age, classical cardiovascular disease (CVD) and other risk factors.
Methods: This study included a cross-sectional analysis of cIMT in 178 patients with type 1 diabetes and 208 healthy controls across age categories. In patients, the impact of gender, socio-economic status, ethnicity, current and historical body mass index, blood pressure, hemoglobin A1c, high-density lipoprotein, and low-density lipoprotein cholesterol on cIMT was studied in a retrospective follow-up cohort study.
Introduction: Erythrocytes carry apolipoprotein B on their membrane, but the determining factors of erythrocyte-bound apolipoprotein B (ery-apoB) are unknown. We aimed to explore the determinants of ery-apoB to gain more insight into potential mechanisms.
Methods: Subjects with and without CVD were included (N = 398).
Article Synopsis
- ApoB-containing lipoproteins are found on erythrocytes, and their levels are linked to the presence of atherosclerosis in patients.
- In a study with 166 subjects, those with coronary artery disease (CAD+) had lower levels of erythrocyte-bound apoB (ery-apoB) compared to those without CAD (CAD-).
- Higher levels of ery-apoB were associated with a reduced risk of CAD, although this protective effect decreased with age, and there was a negative correlation between ery-apoB levels and intima media thickness, a marker for atherosclerosis.
Lipoprotein transport is thought to occur in the plasma compartment of the blood, where lipoproteins are modulated by various enzymatic reactions. Subsequently, lipoproteins can migrate through the endothelial barrier to the subendothelial space or are taken up by the liver. The interaction between pro-atherogenic (apoB-containing) lipoproteins and blood cells (especially monocytes and macrophages) in the subendothelial space is well known.
View Article and Find Full Text PDFDehydroepiandrosterone (DHEA) and its ester dehydroepiandrosterone sulphate (DHEAS) are produced by the adrenal glands. These hormones are inactive precursors that are transformed into active sex steroids in peripheral target tissues. After a peak in early adulthood, there is a marked decrease in plasma concentrations throughout adult life.
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